INT56030

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Context Info
Confidence 0.62
First Reported 1994
Last Reported 2009
Negated 3
Speculated 2
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 4.06
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
Brains 4
App (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 4 100.00 Very High Very High Very High
long-term potentiation 5 99.88 Very High Very High Very High
qutenza 9 99.72 Very High Very High Very High
Morphine 4 99.62 Very High Very High Very High
anesthesia 5 97.12 Very High Very High Very High
IPN 2 89.68 High High
Hippocampus 6 82.56 Quite High
Inflammation 3 76.36 Quite High
halothane 1 75.20 Quite High
Opioid 1 67.52 Quite High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 15 100.00 Very High Very High Very High
Cognitive Disorder 7 99.40 Very High Very High Very High
Disease 32 97.44 Very High Very High Very High
Dementia 3 95.84 Very High Very High Very High
Injury 5 90.44 High High
Inflammatory Pain 2 89.68 High High
Adhesions 1 85.16 High High
INFLAMMATION 3 76.36 Quite High
Brain Injury 8 75.00 Quite High
Nociception 2 50.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As such, the effect of anesthetics on APP protein and mRNA levels was assessed utilizing semiquantitative Western-immunoblot and reverse transcription polymerase chain reaction (RT-PCR) in brains of rats following intraperitoneal treatment with propofol and thiopental.
Regulation (effect) of APP in brains
1) Confidence 0.62 Published 2005 Journal Neurochem. Res. Section Abstract Doc Link 16258851 Disease Relevance 0.45 Pain Relevance 0.10
Firstly, to minimize the possibility of migration bias and secondly to better handle the possibility that the participants' reporting of APP could be affected by the air pollution levels at the time of answering the questionnaire, rather than being a reflection of what it is like in the area of living during the year as a whole.
Regulation (affected) of APP
2) Confidence 0.61 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0 Pain Relevance 0
Effect of general anesthetics on amyloid precursor protein and mRNA levels in the rat brain.
Regulation (Effect) of amyloid precursor protein in brain associated with alzheimer's dementia
3) Confidence 0.54 Published 2005 Journal Neurochem. Res. Section Title Doc Link 16258851 Disease Relevance 0.47 Pain Relevance 0.09
In contrast, in the applied single dosage chronic morphine treatment did not influence either the APP and BACE protein levels or the APP mRNA production.
Neg (not) Regulation (influence) of APP associated with morphine
4) Confidence 0.45 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16487451 Disease Relevance 0.24 Pain Relevance 0.41
Brains were dissected and analysed for amyloid precursor protein (APP) and other synaptic and cytoskeletal proteins using Western blotting.
Spec (analysed) Regulation (analysed) of amyloid precursor protein in Brains associated with alzheimer's dementia
5) Confidence 0.45 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12492435 Disease Relevance 0.45 Pain Relevance 0.19
Brains were dissected and analysed for amyloid precursor protein (APP) and other synaptic and cytoskeletal proteins using Western blotting.
Spec (analysed) Regulation (analysed) of APP in Brains associated with alzheimer's dementia
6) Confidence 0.45 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12492435 Disease Relevance 0.45 Pain Relevance 0.19
The anesthetics did not change cortical APP protein and mRNA concentration considerably.
Neg (not) Regulation (change) of APP
7) Confidence 0.39 Published 2005 Journal Neurochem. Res. Section Abstract Doc Link 16258851 Disease Relevance 0.41 Pain Relevance 0.09
The APP mRNA and PKC and BACE protein levels were unchanged after capsaicin treatment.
Neg (unchanged) Regulation (unchanged) of APP mRNA associated with kinase c and qutenza
8) Confidence 0.27 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19428784 Disease Relevance 0.32 Pain Relevance 0.92
Ninety minutes after the induction of LTP, the concentrations of NCAM and APP increased, in an NMDA-dependent manner, in the absence of changes in neurofilament and arylsulphatase levels.
Regulation (concentrations) of APP associated with long-term potentiation
9) Confidence 0.23 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8047297 Disease Relevance 0.24 Pain Relevance 0.22
Morphological differences between these animals, such as dark cell change, caspase-3 and APP immunoreactivity, were also investigated.
Regulation (immunoreactivity) of APP
10) Confidence 0.21 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17362936 Disease Relevance 1.02 Pain Relevance 0.11

General Comments

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