INT56031

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Context Info
Confidence 0.69
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 13.46
Pain Relevance 7.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
dentate gyrus 3
cleavage 3
perivascular macrophages 1
brain 1
App (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 5 100.00 Very High Very High Very High
qutenza 9 99.98 Very High Very High Very High
long-term potentiation 20 99.34 Very High Very High Very High
Abeta 33 98.24 Very High Very High Very High
Kinase C 4 97.76 Very High Very High Very High
agonist 3 97.00 Very High Very High Very High
Morphine 4 94.32 High High
Demyelination 4 93.68 High High
tetrodotoxin 1 92.04 High High
Multiple sclerosis 13 90.40 High High
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 48 100.00 Very High Very High Very High
Diabetes Mellitus 40 99.76 Very High Very High Very High
Adhesions 8 99.28 Very High Very High Very High
Disease 268 99.12 Very High Very High Very High
Toxicity 4 97.96 Very High Very High Very High
Demyelinating Disease 18 93.68 High High
Nociception 1 90.28 High High
INFLAMMATION 25 89.44 High High
Depression 90 89.00 High High
Multiple Sclerosis 5 87.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Region-specific increases in brain levels of APP, neurofilament-70 (NF-70), and platelet-activating factor receptor (PAF-R) were found in EC rats.
Positive_regulation (increases) of APP in brain
1) Confidence 0.69 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12492435 Disease Relevance 0.42 Pain Relevance 0.22
Fluorimetrically measured immunoreactivity (-ir) was significantly decreased for paranodin (PN, the requisite axonal paranodal junction protein) and significantly increased for amyloid precursor protein (APP), indicating loss of paranodal junctions and impaired fast axonal transport, respectively.
Positive_regulation (increased) of APP associated with alzheimer's dementia
2) Confidence 0.68 Published 2007 Journal J. Neurosci. Methods Section Abstract Doc Link 17719649 Disease Relevance 1.28 Pain Relevance 0.69
Fluorimetrically measured immunoreactivity (-ir) was significantly decreased for paranodin (PN, the requisite axonal paranodal junction protein) and significantly increased for amyloid precursor protein (APP), indicating loss of paranodal junctions and impaired fast axonal transport, respectively.
Positive_regulation (increased) of amyloid precursor protein associated with alzheimer's dementia
3) Confidence 0.68 Published 2007 Journal J. Neurosci. Methods Section Abstract Doc Link 17719649 Disease Relevance 1.28 Pain Relevance 0.69
Inducible nitric oxide synthase (iNOS) expression in perivascular macrophages was associated with a transient functional disturbance of axons, reflected by the focal and reversible accumulation of amyloid precursor protein.
Positive_regulation (accumulation) of amyloid precursor protein in perivascular macrophages associated with alzheimer's dementia
4) Confidence 0.61 Published 2006 Journal Acta Neuropathol. Section Abstract Doc Link 16718350 Disease Relevance 1.25 Pain Relevance 0.27
In all seasons there was an increase in APP with increased levels of NO2, even though mean levels of NO2 were significantly higher in winter for all quintiles and statistically lower in summer for all quintiles.
Positive_regulation (increase) of APP
5) Confidence 0.60 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.41 Pain Relevance 0.04
The extracellular concentrations of the amyloid precursor protein (APP) and neural-cell adhesion molecule (NCAM) in the dentate gyrus of the anaesthetized rat were assayed before and after the induction of long-term potentiation (LTP) in vivo.
Positive_regulation (concentrations) of amyloid precursor protein in dentate gyrus associated with alzheimer's dementia, long-term potentiation and adhesions
6) Confidence 0.48 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8047297 Disease Relevance 0.27 Pain Relevance 0.17
The extracellular concentrations of the amyloid precursor protein (APP) and neural-cell adhesion molecule (NCAM) in the dentate gyrus of the anaesthetized rat were assayed before and after the induction of long-term potentiation (LTP) in vivo.
Positive_regulation (concentrations) of APP in dentate gyrus associated with alzheimer's dementia, long-term potentiation and adhesions
7) Confidence 0.48 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8047297 Disease Relevance 0.27 Pain Relevance 0.17
A concomitant 25% increase was found both in the beta-secretase (BACE) and APP mRNA levels (108%).
Positive_regulation (increase) of APP
8) Confidence 0.47 Published 2007 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 16487451 Disease Relevance 0.26 Pain Relevance 0.41
Capsaicin enhanced the level of membrane-bound APP 1.7-fold.
Positive_regulation (enhanced) of APP associated with qutenza
9) Confidence 0.46 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19428784 Disease Relevance 0.32 Pain Relevance 0.92
We divided the participants in two groups, those who reported APP and those who did not (Table 1).
Positive_regulation (reported) of APP
10) Confidence 0.44 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.05 Pain Relevance 0.03
For all variables except diabetes, those who reported APP were exposed to significantly higher levels of NO2.
Positive_regulation (reported) of APP associated with diabetes mellitus
11) Confidence 0.44 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.37 Pain Relevance 0.04
APP increased significantly by levels of NO2. 7.9% in the quintile with lowest levels of NO2 reported APP, 12.3% in the second quintile, 22.6% in the third quintile, 27.5% in the fourth quintile and 33.1% in the fifth quintile (not shown in tables).
Positive_regulation (increased) of APP
12) Confidence 0.41 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.12 Pain Relevance 0.03
APP increased significantly by levels of NO2. 7.9% in the quintile with lowest levels of NO2 reported APP, 12.3% in the second quintile, 22.6% in the third quintile, 27.5% in the fourth quintile and 33.1% in the fifth quintile (not shown in tables).
Positive_regulation (increased) of APP
13) Confidence 0.41 Published 2008 Journal Environ Health Section Body Doc Link PMC2289819 Disease Relevance 0.12 Pain Relevance 0.03
Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized rats.
Positive_regulation (Increase) of amyloid precursor protein in dentate gyrus associated with anesthesia, alzheimer's dementia and long-term potentiation
14) Confidence 0.39 Published 1994 Journal Neurosci. Lett. Section Title Doc Link 8047297 Disease Relevance 0.29 Pain Relevance 0.31
Ninety minutes after the induction of LTP, the concentrations of NCAM and APP increased, in an NMDA-dependent manner, in the absence of changes in neurofilament and arylsulphatase levels.
Positive_regulation (increased) of APP associated with long-term potentiation
15) Confidence 0.39 Published 1994 Journal Neurosci. Lett. Section Abstract Doc Link 8047297 Disease Relevance 0.24 Pain Relevance 0.22
These findings suggest that long-term administration of ChEI to Alzheimer's disease (AD) patients may have a neuroprotective effect by activating normal APP processing and decreasing the formation of amyloidogenic APP products.
Positive_regulation (activating) of APP associated with disease
16) Confidence 0.39 Published 1996 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8624119 Disease Relevance 0.16 Pain Relevance 0.09
In addition, IBU-PO enhances, dose-dependently, the non-amyloidogenic amyloid precursor protein (APP) cleavage by increasing secreted APP and decreasing endogenous Abeta1-40 in rat hippocampal neurons.
Positive_regulation (enhances) of amyloid precursor protein in cleavage associated with alzheimer's dementia
17) Confidence 0.38 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15649708 Disease Relevance 0.66 Pain Relevance 0.32
In addition, IBU-PO enhances, dose-dependently, the non-amyloidogenic amyloid precursor protein (APP) cleavage by increasing secreted APP and decreasing endogenous Abeta1-40 in rat hippocampal neurons.
Positive_regulation (enhances) of APP in cleavage associated with alzheimer's dementia
18) Confidence 0.38 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15649708 Disease Relevance 0.66 Pain Relevance 0.32
In addition, IBU-PO enhances, dose-dependently, the non-amyloidogenic amyloid precursor protein (APP) cleavage by increasing secreted APP and decreasing endogenous Abeta1-40 in rat hippocampal neurons.
Positive_regulation (increasing) of APP in cleavage associated with alzheimer's dementia
19) Confidence 0.34 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15649708 Disease Relevance 0.65 Pain Relevance 0.31
Increases in the level of Abeta in NB cells following an elevation of intracellular cAMP levels appear to be due to an increase in the rate of processing of the amyloid precursor protein (APP) rather than an increase in the expression of APP.
Positive_regulation (increase) of amyloid precursor protein associated with alzheimer's dementia and abeta
20) Confidence 0.29 Published 1998 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 9790168 Disease Relevance 0.73 Pain Relevance 0.40

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