INT56032

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 38
Total Number 38
Disease Relevance 26.01
Pain Relevance 4.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NCAM1) cell adhesion (NCAM1) plasma membrane (NCAM1)
Anatomy Link Frequency
T-cell 7
NK cells 6
B cells 2
bars 1
pons 1
NCAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 22 100.00 Very High Very High Very High
medulla 39 99.96 Very High Very High Very High
Acupuncture 56 99.86 Very High Very High Very High
chemokine 13 98.64 Very High Very High Very High
long-term potentiation 5 95.96 Very High Very High Very High
analgesia 3 95.52 Very High Very High Very High
cytokine 81 94.40 High High
abdominal pain 9 94.36 High High
depression 5 91.84 High High
cva 15 91.24 High High
Disease Link Frequency Relevance Heat
Adhesions 25 100.00 Very High Very High Very High
Alzheimer's Dementia 2 100.00 Very High Very High Very High
Cancer 537 99.62 Very High Very High Very High
Hepatitis C Virus Infection 352 99.40 Very High Very High Very High
Opiate Addiction 237 99.24 Very High Very High Very High
Stomach Cancer 1 98.32 Very High Very High Very High
Infection 216 98.24 Very High Very High Very High
Ganglion Cysts 71 98.12 Very High Very High Very High
Metastasis 90 97.88 Very High Very High Very High
Adenocarcinoma 7 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, activated CD56brightCD16- NK cells also produce chemokines CXCL8, CCL4, CCL5 and CCL22 [33,34].
Positive_regulation (activated) of CD56 in NK cells associated with chemokine
1) Confidence 0.49 Published 2010 Journal J Transl Med Section Body Doc Link PMC2829521 Disease Relevance 0.40 Pain Relevance 0.39
-CD56/CD68 double immunohistochemistry sections were blocked in normal goat serum (NGS, one part serum, four parts PBS plus 5% BSA) and subsequently incubated overnight with a polyclonal anti-IL11R?
Positive_regulation (sections) of CD56
2) Confidence 0.49 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
CD3(-)CD16(+)CD56(+) NK cell counts and NKCA were significantly (P < 0.05) elevated at each 30-min interval of exercise compared with correspondingly timed resting control values.
Positive_regulation (elevated) of CD56 in NK cell
3) Confidence 0.45 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9843861 Disease Relevance 0 Pain Relevance 0.10
In contrast, NK cell (CD16+/CD56+) numbers significantly increased in response to fentanyl.
Positive_regulation (increased) of CD56 in NK cell
4) Confidence 0.45 Published 1999 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 10454018 Disease Relevance 0 Pain Relevance 0.24
A prospective randomized controlled trial was designed to observe expressions of T-lymphocyte subsets (CD3(+), CD3(+)CD4(+) and CD3(+)CD8(+)), natural-killer cells (CD3(-)CD16(+)CD56(+)), and activated T-lymphocytes (CD3(+)CD25(+)) of patients undergoing gastric cancer surgeries and receiving patient-controlled intravenous analgesia (PCIA).
Positive_regulation (activated) of CD56 in T-lymphocytes associated with stomach cancer and analgesia
5) Confidence 0.45 Published 2006 Journal Clin. Chim. Acta Section Abstract Doc Link 16487501 Disease Relevance 0.35 Pain Relevance 0.66
PSA-NCAM is mainly distributed at the level of the medulla oblongata and pons and appears scarce in the mesencephalon.
Positive_regulation (distributed) of PSA-NCAM in medulla oblongata associated with medulla
6) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2612005 Disease Relevance 0.08 Pain Relevance 0.14
In the brainstem, PSA-NCAM is mainly distributed at the level of the medulla oblongata and pons and appears scarce in the mesencephalon.
Positive_regulation (distributed) of PSA-NCAM in mesencephalon associated with medulla
7) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2612005 Disease Relevance 0.43 Pain Relevance 0.41
The relative abundance of these elements in IL-12-stimulated CD56+ T cells were correlated to GAPDH mRNA and there was no difference in the expression patterns of these mRNAs between normal subjects, heroin users with HCV infection, and heroin users without HCV infection (P>0.05) (Fig. 6).
Positive_regulation (abundance) of CD56 in T cells associated with hepatitis c virus infection, opiate addiction and infection
8) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.40 Pain Relevance 0.03
Although there was an increase in PIAS-3 levels in CD56+ T cells from the heroin users without HCV infection, this difference was not statistically significant (Fig. 7).
Positive_regulation (increase) of CD56 in T cells associated with hepatitis c virus infection, opiate addiction and infection
9) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.65 Pain Relevance 0.04
The CD19+ counts, which are closely associated with activity of B cells, significantly increased on day 8 after acupuncture, like variations of CD16+ and CD56+ counts.
Positive_regulation (variations) of CD56 in B cells associated with acupuncture
10) Confidence 0.35 Published 2007 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2176150 Disease Relevance 0 Pain Relevance 0.29
Immunohistochemistry of the tumorectomy and autopsy specimens was positive for cytokeratins, neuron-specific enolase, synaptophysin, CD56, KIT and PDGFRA, and negative for chromogranin and thyroid transcriptional factor-1.
Positive_regulation (positive) of CD56 in thyroid
11) Confidence 0.35 Published 2009 Journal Pathol. Int. Section Abstract Doc Link 19351368 Disease Relevance 0.61 Pain Relevance 0.08
During the treatment pause (L6+2, L6+8, L6+12 weeks after leukapheresis L6; hatched bars) the levels of CD56 and CD94 gradually dropped but could be enhanced by additional stimulation cycles.
Positive_regulation (enhanced) of CD56 in bars
12) Confidence 0.27 Published 2009 Journal J Transl Med Section Body Doc Link PMC2714296 Disease Relevance 0 Pain Relevance 0
Compared to the PBMNC, which were obtained before the start of the therapy, the CD3- NK cells exhibited an increased density of activatory NK cell markers such as CD94/NKG2C, CD16/CD56, NKG2D, CD25 and the NCRs NKp30, NKp44, NKp46, although the absolute number of NK cells remained unaffected.
Positive_regulation (increased) of CD56 in NK cells
13) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2714296 Disease Relevance 0.39 Pain Relevance 0
In summary and in line with the data of the phase I clinical trial, a comparative analysis of leukapheresis products which were obtained before and after in vitro stimulation with TKD/IL-2 revealed an increase in the surface densities of CD94 and CD56.
Positive_regulation (increase) of CD56
14) Confidence 0.26 Published 2009 Journal J Transl Med Section Body Doc Link PMC2714296 Disease Relevance 0 Pain Relevance 0
In our study, the accumulation of CD56+, CD3+
Positive_regulation (accumulation) of CD56
15) Confidence 0.20 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246050 Disease Relevance 0.34 Pain Relevance 0.08
When stimulated by IL-12, CD56+ T cells from HCV-infected heroin users produced significantly lower levels of IFN-?
Positive_regulation (stimulated) of CD56 in T cells associated with opiate addiction and hepatitis c virus infection
16) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.24 Pain Relevance 0
The tumor cells showed positive reactivity for synaptophysin, somatostatin, and CD56.
Positive_regulation (reactivity) of CD56 associated with cancer and somatostatin
17) Confidence 0.15 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2874790 Disease Relevance 1.33 Pain Relevance 0.15
Epithelioid cells showed positive reactivity for synaptophysin, somatostatin, and CD56.
Positive_regulation (reactivity) of CD56 associated with somatostatin
18) Confidence 0.15 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC2874790 Disease Relevance 1.00 Pain Relevance 0.18
Both fractions induced the CD69 activation marker on human CD3-negative, CD56-positive NK cells, and also enhanced the transient expression of CD107a as an indication of increased NK cell cytotoxicity in the presence of transformed cells.
Positive_regulation (induced) of CD56 in NK cells
19) Confidence 0.15 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.16 Pain Relevance 0.07
PSA-NCAM is mainly distributed at the level of the medulla oblongata and pons and appears scarce in the mesencephalon.
Positive_regulation (distributed) of PSA-NCAM in pons associated with medulla
20) Confidence 0.14 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2612005 Disease Relevance 0.08 Pain Relevance 0.14

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