INT5604

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Context Info
Confidence 0.67
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 47
Total Number 49
Disease Relevance 10.75
Pain Relevance 27.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) plasma membrane (Drd2) signal transducer activity (Drd2)
Anatomy Link Frequency
striatum 3
nucleus accumbens 3
neurons 3
insular cortex 1
shell 1
Drd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 340 100.00 Very High Very High Very High
dopamine receptor 73 100.00 Very High Very High Very High
fluoxetine 7 99.98 Very High Very High Very High
ketamine 101 99.96 Very High Very High Very High
agonist 61 99.96 Very High Very High Very High
Kappa opioid receptor 4 99.84 Very High Very High Very High
cocaine 20 99.80 Very High Very High Very High
Enkephalin 25 99.50 Very High Very High Very High
Migraine 18 99.44 Very High Very High Very High
Ventral tegmentum 15 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Migraine With Aura 10 99.64 Very High Very High Very High
Nociception 27 99.34 Very High Very High Very High
Obesity 7 99.32 Very High Very High Very High
Disease 11 99.12 Very High Very High Very High
INFLAMMATION 52 99.10 Very High Very High Very High
Drug Dependence 22 98.88 Very High Very High Very High
Alcohol Addiction 182 98.76 Very High Very High Very High
Neuropathic Pain 8 98.68 Very High Very High Very High
Eating Disorder 17 98.52 Very High Very High Very High
Hypersensitivity 7 98.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, activation of the D2 dopamine hetero-receptor only modulates the calcium-dependent component of spontaneous [3H]ACh efflux.
Positive_regulation (activation) of D2 dopamine hetero-receptor associated with dopamine
1) Confidence 0.67 Published 2000 Journal Brain Res. Section Abstract Doc Link 10784105 Disease Relevance 0 Pain Relevance 0.38
Medial forebrain bundle stimulation or D-2 dopamine receptor activation increases preproenkephalin mRNA in rat striatum.
Positive_regulation (activation) of D-2 dopamine receptor in striatum associated with dopamine receptor and enkephalin
2) Confidence 0.66 Published 1989 Journal J. Neurochem. Section Title Doc Link 2521894 Disease Relevance 0 Pain Relevance 0.52
Neurochem. 78 (2001) 1094] and associates found increases in the dopamine D2 receptors (DRD2) via adenoviral vector delivery of the DRD2 gene into the nucleus accumbens, significantly reduced both ethanol preference (43%) and alcohol intake (64%) of ethanol preferring rats, which recovered as the DRD2, returned to baseline levels.
Positive_regulation (increases) of DRD2 in nucleus accumbens associated with nucleus accumbens, dopamine and alcohol
3) Confidence 0.65 Published 2004 Journal Med. Hypotheses Section Abstract Doc Link 15288384 Disease Relevance 0.14 Pain Relevance 0.60
A smaller but consistent increase in dopamine D2 receptor mRNA levels was also found on adjacent sections of the striatum only in animals injected with 150 micrograms of 6-hydroxydopamine.
Positive_regulation (increase) of dopamine D2 receptor in striatum associated with dopamine
4) Confidence 0.58 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902185 Disease Relevance 0 Pain Relevance 0.40
Repeated treatment with FNM also resulted in statistically significant increases in D2 dopamine receptor mRNA but decreases in D1 dopamine receptor mRNA.
Positive_regulation (increases) of D2 dopamine receptor associated with dopamine receptor
5) Confidence 0.54 Published 1994 Journal Neurochem. Int. Section Abstract Doc Link 7820070 Disease Relevance 0 Pain Relevance 0.81
Imipramine, but not fluoxetine, increased the D2 receptor message in the VTA, but only in the non-stressed group.
Positive_regulation (increased) of D2 receptor associated with ventral tegmentum and fluoxetine
6) Confidence 0.53 Published 1997 Journal Behav Pharmacol Section Abstract Doc Link 9832973 Disease Relevance 0.50 Pain Relevance 0.83
Both imipramine and fluoxetine increased the D2 receptor message in the lateral, but not the medial, part of the caudate nucleus and in the shell, but not the core, of the nucleus accumbens.
Positive_regulation (increased) of D2 receptor in shell associated with nucleus accumbens and fluoxetine
7) Confidence 0.53 Published 1997 Journal Behav Pharmacol Section Abstract Doc Link 9832973 Disease Relevance 0.45 Pain Relevance 0.85
Autoradiographic analysis of [(3)H]7-OH-DPAT and [(3)H]raclopride binding revealed a significant up-regulation of dopamine D2 and D3 receptors in the rat nucleus accumbens upon repeated treatment with tramadol.
Positive_regulation (up-regulation) of dopamine D2 in nucleus accumbens associated with tramadol, nucleus accumbens and dopamine
8) Confidence 0.52 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464068 Disease Relevance 0.09 Pain Relevance 0.94
These results indicate that partial lesions of the NS DA projections are sufficient to cause substantial increases in PEK mRNA but not in D2 receptor mRNA.
Positive_regulation (increases) of D2 receptor mRNA in PEK
9) Confidence 0.51 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1312206 Disease Relevance 0 Pain Relevance 0.04
Conversely, only the High rotation group showed significant increases (+112%) in D2 receptor mRNA which occurred only on the lesioned side.
Positive_regulation (increases) of D2 receptor mRNA
10) Confidence 0.51 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1312206 Disease Relevance 0 Pain Relevance 0.04
Subanesthetic concentrations of the anesthetics, including ketamine, stimulated the incorporation of GTP into the cloned dopamine D2 receptors.
Positive_regulation (stimulated) of dopamine D2 associated with dopamine and ketamine
11) Confidence 0.50 Published 2003 Journal Synapse Section Abstract Doc Link 12872292 Disease Relevance 0 Pain Relevance 0.66
These data suggest that several treatment regimens for cocaine addiction alter the cardiovascular responses to cocaine and that dopamine D2 receptor activation may be necessary for the decrease in cardiac output noted in vascular responders.
Positive_regulation (activation) of dopamine D2 receptor associated with addiction, dopamine and cocaine
12) Confidence 0.48 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353374 Disease Relevance 0.17 Pain Relevance 0.68
Numerous case-control studies have addressed the hypothesis that variant alleles of the dopamine D2 receptor gene (DRD2) increase the liability for alcohol and/or drug dependence, and both positive and negative results have been reported.
Positive_regulation (increase) of DRD2 associated with drug dependence, addiction, dopamine and alcohol
13) Confidence 0.48 Published 2000 Journal Am. J. Med. Genet. Section Abstract Doc Link 11054774 Disease Relevance 0.17 Pain Relevance 0.40
Further analysis showed that the more severe alcoholics had a 3-fold higher prevalence of the DRD2 A1 allele than the assessed controls (p < 10(-10)), whereas no difference was found between the less severe alcoholics and the unassessed controls.
Positive_regulation (prevalence) of DRD2 associated with dopamine receptor
14) Confidence 0.48 Published 2000 Journal Pharmacogenomics Section Abstract Doc Link 11256581 Disease Relevance 0.51 Pain Relevance 0.44
The effect of apomorphine was not influenced by co-treatment with SK & F 38393 or quinpirole, indicating that apomorphine induces a comparable D-1 and D-2 receptor stimulation in vivo also.
Positive_regulation (induces) of D-2 receptor
15) Confidence 0.47 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3500865 Disease Relevance 0 Pain Relevance 0.35
These observations confirm previous findings that inhibitory effects of DA on suckling-induced OT release are mediated through activation of the D-2 DA receptor.
Positive_regulation (activation) of D-2 DA receptor associated with dopamine
16) Confidence 0.46 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1831247 Disease Relevance 0 Pain Relevance 0.81
Stimulation of the D-2 DA receptor with PPHT had no effect on basal OT release in nonsuckled rats, but this agent, as well as another D-2 DA agonist, bromocriptine, prevented the suckling-induced release of both OT and PRL.
Positive_regulation (Stimulation) of D-2 DA receptor associated with dopamine and agonist
17) Confidence 0.46 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1831247 Disease Relevance 0 Pain Relevance 0.78
The results indicate that activation of the dopamine D2 receptor in A11 may selectively suppress neuropathic hypersensitivity, due to mechanisms that involve GABA(A) receptors in the hypothalamus and descending noradrenergic pathways acting on spinal alpha(2)-adrenoceptors, possibly together with a slight contribution of descending serotoninergic pathways acting on spinal 5-HT(1A) receptors.
Positive_regulation (activation) of dopamine D2 receptor in A11 associated with gaba, dopamine, hypersensitivity and neuropathic pain
18) Confidence 0.46 Published 2009 Journal Pharmacol. Res. Section Abstract Doc Link 19416636 Disease Relevance 0.74 Pain Relevance 0.88
It remains to be elucidated whether the associations with TaqI A are due to its own functionality or linkage disequilibrium with another DRD2 variation or with the ANKK1 gene [45].
Positive_regulation (variation) of DRD2
19) Confidence 0.44 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829542 Disease Relevance 0.28 Pain Relevance 0.26
TaqI A SNP is regarded as the most dramatic polymorphism of DRD2 for its highly inconsistent association with AD.
Positive_regulation (polymorphism) of DRD2 associated with addiction
20) Confidence 0.44 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2829542 Disease Relevance 0.42 Pain Relevance 0.20

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