INT56040

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Context Info
Confidence 0.28
First Reported 1994
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 2.00
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger2) signal transducer activity (Ptger2)
Anatomy Link Frequency
PGE2 6
dorsal 2
paw 2
MDCK 2
microglial cells 2
Ptger2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 6 99.98 Very High Very High Very High
cINOD 7 98.72 Very High Very High Very High
Spinal cord 7 98.16 Very High Very High Very High
Inflammation 19 96.64 Very High Very High Very High
substance P 6 96.40 Very High Very High Very High
dexamethasone 5 90.20 High High
intrathecal 3 89.20 High High
acular 3 88.92 High High
aspirin 4 81.28 Quite High
cytokine 3 51.04 Quite High
Disease Link Frequency Relevance Heat
Asthma 13 100.00 Very High Very High Very High
INFLAMMATION 25 98.00 Very High Very High Very High
Necrosis 3 75.00 Quite High
Cancer 3 75.00 Quite High
Injury 7 73.76 Quite High
Brain Injury 12 25.16 Quite Low
Cv Unclassified Under Development 3 23.60 Low Low
Disease 4 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 3 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an analogous manner, treating sensory neurons grown in culture with 1 microM PGE2 for 24 h decreased [3H]-PGE2 binding by approximately 50% without altering binding affinity.
Negative_regulation (decreased) of PGE2 Binding (binding) of in PGE2
1) Confidence 0.28 Published 2002 Journal Pain Section Abstract Doc Link 11973001 Disease Relevance 0.36 Pain Relevance 0.44
Injection of complete Freund's adjuvant into the hindpaw decreased binding of PGE2 in ipsilateral, but not contralateral dorsal spinal cord 24 h after injection.
Neg (not) Negative_regulation (decreased) of PGE2 Binding (binding) of in dorsal associated with spinal cord
2) Confidence 0.28 Published 2002 Journal Pain Section Abstract Doc Link 11973001 Disease Relevance 0.39 Pain Relevance 0.43
These results demonstrate that under conditions that significantly downregulate PGE2 binding, sensory neurons are still capable of maintaining PGE2-mediated sensitization.
Negative_regulation (downregulate) of PGE2 Binding (binding) of in PGE2
3) Confidence 0.28 Published 2002 Journal Pain Section Abstract Doc Link 11973001 Disease Relevance 0.15 Pain Relevance 0.29
In carrageenan induced rat paw edema, ML3000 and indomethacin completely blocked the formation of PGE2 in the inflamed tissue.
Negative_regulation (blocked) of PGE2 Binding (formation) of in paw
4) Confidence 0.06 Published 2002 Journal Inflamm. Res. Section Body Doc Link 12005204 Disease Relevance 0 Pain Relevance 0
Resveratrol effects on mPGES-1 expression seem to be independent on its ability to reduce COX activity/PGE2 formation since other COX inhibitors were unable to modify LPS-induced mPGES-1 upregulation in microglial cells despite their potent inhibitory effects on PGE2 production (Figs. 6 and 7).
Negative_regulation (reduce) of PGE2 Binding (formation) of in microglial cells
5) Confidence 0.03 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0 Pain Relevance 0
A functional SNP of the EP2 gene associated with risk of AIA should decrease the transcription level, resulting in reduction of the PGE(2) braking mechanism of inflammation and involvement in the molecular mechanism underlying AIA.
Negative_regulation (decrease) of EP2 Binding (associated) of associated with asthma and inflammation
6) Confidence 0.03 Published 2004 Journal Hum. Mol. Genet. Section Abstract Doc Link 15496426 Disease Relevance 0.77 Pain Relevance 0.13
In the present study, we demonstrate that the inhibitory effects of PGE2 on Na-K-ATPase activity, ouabain-sensitive Rb+ uptake, and ouabain binding in MDCK cells were diminished by treatment of the cells with nonsteroidal anti-inflammatory drugs.
Negative_regulation (diminished) of PGE2 Binding (binding) of in MDCK associated with inflammation and cinod
7) Confidence 0.02 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8048570 Disease Relevance 0.10 Pain Relevance 0.13
Finally, we demonstrated that dopamine inhibits Rb+ influx and ouabain binding in MDCK cells similarly to PGE2.
Negative_regulation (inhibits) of PGE2 Binding (binding) of in PGE2 associated with dopamine
8) Confidence 0.02 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 8048570 Disease Relevance 0.08 Pain Relevance 0.22
Cells stimulated with the NS-398 after TNF-alpha exposure demonstrated suppression of TNF-alpha-stimulated PGE2 formation.
Negative_regulation (suppression) of PGE2 Binding (formation) of
9) Confidence 0.00 Published 1997 Journal Placenta Section Abstract Doc Link 9290146 Disease Relevance 0.15 Pain Relevance 0.28

General Comments

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