INT56043

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Context Info
Confidence 0.69
First Reported 1994
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 5
Disease Relevance 1.20
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Btd) extracellular region (Btd) nucleolus (Btd)
Anatomy Link Frequency
liver 2
cerebrospinal fluid 2
plasma 1
Btd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 9 99.08 Very High Very High Very High
Opioid 2 98.76 Very High Very High Very High
Neuropeptide 2 98.48 Very High Very High Very High
Inflammation 2 97.40 Very High Very High Very High
Central nervous system 2 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Subacute Sclerosing Panencephalitis 4 98.96 Very High Very High Very High
Injury 3 97.80 Very High Very High Very High
INFLAMMATION 2 97.40 Very High Very High Very High
Meningitis 4 96.68 Very High Very High Very High
Cirrhosis 3 91.72 High High
Overdose 3 90.92 High High
Necrosis 3 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, 24 and 40 h after the toxic dose of paracetamol, biotinidase activity was decreased in the liver and increased in the plasma as compared with the control, when plasma ALT was increased.
Positive_regulation (increased) of biotinidase in plasma
1) Confidence 0.69 Published 2004 Journal Clin. Chim. Acta Section Body Doc Link 15469856 Disease Relevance 0 Pain Relevance 0
Increased plasma biotinidase activity in rats with paracetamol-induced acute liver injury.
Positive_regulation (Increased) of biotinidase in liver associated with paracetamol and injury
2) Confidence 0.69 Published 2004 Journal Clin. Chim. Acta Section Title Doc Link 15469856 Disease Relevance 0.37 Pain Relevance 0.27
CONCLUSION: The increase in plasma biotinidase activity may serve as an indicator of paracetamol-induced acute liver injury in the rat.


Positive_regulation (increase) of biotinidase in liver
3) Confidence 0.69 Published 2004 Journal Clin. Chim. Acta Section Body Doc Link 15469856 Disease Relevance 0 Pain Relevance 0
An early increase in activity of biotinidase in the cerebrospinal fluid (CSF) during the course of acute Staphylococcus aureus meningitis in a subject with subacute sclerosing panencephalitis (SSPE) is reported.
Positive_regulation (increase) of biotinidase in cerebrospinal fluid associated with meningitis and subacute sclerosing panencephalitis
4) Confidence 0.38 Published 1994 Journal Brain Dev. Section Abstract Doc Link 8048707 Disease Relevance 0.36 Pain Relevance 0.20
A possible role of CSF biotinidase in the hydrolysis of specific opioid neuropeptides during acute inflammatory processes involving the CSF-central nervous system compartment is suggested.
Spec (possible) Positive_regulation (role) of CSF biotinidase in CSF associated with inflammation, neuropeptide, central nervous system and opioid
5) Confidence 0.38 Published 1994 Journal Brain Dev. Section Abstract Doc Link 8048707 Disease Relevance 0.47 Pain Relevance 0.24

General Comments

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