INT56045

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Context Info
Confidence 0.69
First Reported 1994
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.38
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ACE) peptidase activity (ACE) extracellular space (ACE)
extracellular region (ACE) plasma membrane (ACE)
Anatomy Link Frequency
nasal 4
smooth muscle cells 2
ACE (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 16 100.00 Very High Very High Very High
Inflammation 6 100.00 Very High Very High Very High
Enkephalin 2 93.08 High High
Inflammatory response 1 91.92 High High
superficial lamina 2 67.12 Quite High
Pain 7 46.52 Quite Low
antagonist 5 34.96 Quite Low
beta blocker 7 30.88 Quite Low
cva 3 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 8 100.00 Very High Very High Very High
INFLAMMATION 7 100.00 Very High Very High Very High
Cardiovascular Disease 7 97.84 Very High Very High Very High
Atherosclerosis 34 92.64 High High
Adhesions 3 88.52 High High
Coronary Artery Disease 9 80.84 Quite High
Disease 5 74.68 Quite High
Peripheral Arterial Disease 61 71.52 Quite High
Pain 7 46.52 Quite Low
Increased Venous Pressure Under Development 6 12.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Allergen challenge also induced nasal secretion of ACE.
Positive_regulation (induced) of Localization (secretion) of ACE in nasal
1) Confidence 0.69 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 8049077 Disease Relevance 0.20 Pain Relevance 0.22
Topical application of histamine stimulated secretion of ACE activity into nasal lavage fluid (2.90 +/- 0.88 versus 1.53 +/- 0.45 U/liter after saline provocation, P < 0.05 by Bz-Gly-Gly-Gly assay).
Positive_regulation (stimulated) of Localization (secretion) of ACE in nasal
2) Confidence 0.69 Published 1994 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 8049077 Disease Relevance 0.23 Pain Relevance 0.23
The antiatherogenic ACE-I properties may be related both to the inhibition of tissue and circulating Ang II formation and to bradykinin potentiation, resulting in decreased proliferation and migration of smooth muscle cells, decreased accumulation and activation of inflammatory cells, decreased oxidative stress, and increased endothelial NO formation, leading to improved endothelial function.
Neg (NO) Positive_regulation (increased) of Localization (leading) of ACE-I in smooth muscle cells associated with stress, inflammation and bradykinin
3) Confidence 0.49 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.95 Pain Relevance 0.15

General Comments

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