INT56047

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Context Info
Confidence 0.59
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 8.02
Pain Relevance 5.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
brain 4
hippocampal formation 2
neurons 2
spinal cord 2
optic stalk 2
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 213 100.00 Very High Very High Very High
Spinal cord 141 100.00 Very High Very High Very High
Desipramine 1 99.82 Very High Very High Very High
GABAergic 61 99.80 Very High Very High Very High
Morphine 6 99.80 Very High Very High Very High
depression 38 99.70 Very High Very High Very High
fluoxetine 4 99.56 Very High Very High Very High
Analgesic 4 99.44 Very High Very High Very High
Pain 44 99.18 Very High Very High Very High
tolerance 4 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 54 100.00 Very High Very High Very High
Hyperoxia 30 99.98 Very High Very High Very High
Depression 41 99.70 Very High Very High Very High
Apoptosis 30 99.68 Very High Very High Very High
Stress 162 99.62 Very High Very High Very High
Pain 62 99.18 Very High Very High Very High
Neurodegenerative Disease 35 98.24 Very High Very High Very High
Disease 37 97.56 Very High Very High Very High
Spinal Cord Injury 37 96.24 Very High Very High Very High
Ganglion Cysts 6 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results indicated that the spontaneous recovery from the decreased levels of BDNF mRNA and protein 24 h after stress is, at least in part, due to plastic changes in the acetylation status of H3 at the promoters of the BDNF gene.
Negative_regulation (decreased) of Transcription (levels) of BDNF associated with stress
1) Confidence 0.59 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.77 Pain Relevance 0.03
CFA evoked robust decreases in NK-1 receptor and BDNF mRNA levels in the hippocampal formation, contrary to the prominent up-regulation seen in the spinal cord.
Negative_regulation (decreases) of Transcription (levels) of BDNF in hippocampal formation associated with spinal cord
2) Confidence 0.56 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.73 Pain Relevance 0.69
Chronic social defeat stress has been shown to downregulate the mRNA levels of BDNF transcripts IV and VI in the mouse hippocampus, which is accompanied by significant increases in H3-K27 dimethylation at the promoter of exons IV and VI without changes in H3 acetylation status at the promoter of either exons IV or VI.7 This result taken together with our findings suggests that chromatin remodeling through histone modification could play an important role in stress-induced gene expression in vivo.
Negative_regulation (downregulate) of Transcription (levels) of BDNF in hippocampus associated with stress and hippocampus
3) Confidence 0.43 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.85 Pain Relevance 0.24
In situ hybridization assay results demonstrated that either pain or stress (acute or chronic treatments) reduced the levels of both NK-1 receptor and BDNF mRNAs in the cornu ammonis 1-3 sublayers of the hippocampus, suggesting a possible role of these neuromediators in processing of pain in higher brain centers.
Negative_regulation (reduced) of Transcription (levels) of BDNF in brain associated with stress, pain and hippocampus
4) Confidence 0.43 Published 2006 Journal J Pain Section Abstract Doc Link 16885011 Disease Relevance 1.78 Pain Relevance 1.17
Mutant huntingtin (Htt) protein was previously reported to decrease BDNF gene transcription and axonal transport of BDNF.
Negative_regulation (decrease) of Transcription (transcription) of BDNF gene
5) Confidence 0.41 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC2889995 Disease Relevance 0.17 Pain Relevance 0.04
The results contradict with the common BDNF hypothesis of depression that predicts decreased levels of BDNF mRNA in depression-related brain areas (Licinio and Wong, 2002).
Negative_regulation (decreased) of Transcription (levels) of BDNF in brain associated with depression
6) Confidence 0.41 Published 2008 Journal Brain Res Section Body Doc Link PMC2568862 Disease Relevance 0.47 Pain Relevance 0.22
Likewise, hippocampal BDNF mRNA levels were also significantly reduced at 24 h and 4 days after CFA treatments (Fig. 2B).
Negative_regulation (reduced) of Transcription (levels) of BDNF
7) Confidence 0.41 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.20 Pain Relevance 0.32
The yellow channel represents co-localizing puncta of BDNF mRNA and Htt, the magenta channel co-localizing puncta of BDNF mRNA and Ago2, and the cyan channel co-localizing Htt and Ago2.
Negative_regulation (localizing) of Transcription (puncta) of BDNF
8) Confidence 0.41 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
In the PFC, a significant effect of Exploration was revealed on the BDNF mRNA levels normalized with ?
Negative_regulation (revealed) of Transcription (levels) of BDNF
9) Confidence 0.41 Published 2008 Journal Brain Res Section Body Doc Link PMC2568862 Disease Relevance 0 Pain Relevance 0.09
Following an acute injection, all three drugs tested: fluoxetine, desipramine and TCP decreased total BDNF mRNA (exon V) as well as exon IV mRNA, while no significant effect was recorded for exons I and III mRNAs.
Negative_regulation (decreased) of Transcription (mRNA) of BDNF associated with desipramine and fluoxetine
10) Confidence 0.37 Published 2006 Journal Brain Res. Section Abstract Doc Link 16842762 Disease Relevance 0.21 Pain Relevance 0.41
Daily administration of the CREB-binding protein inhibitor curcumin abolished the upregulation of BDNF transcription and morphine analgesic tolerance.
Negative_regulation (abolished) of Transcription (transcription) of BDNF associated with analgesic, tolerance and morphine
11) Confidence 0.36 Published 2009 Journal Neuroreport Section Abstract Doc Link 19033880 Disease Relevance 0 Pain Relevance 1.09
ELISA detection of BDNF in spinal cord and DRG after injury
Negative_regulation (injury) of Transcription (detection) of BDNF in spinal cord associated with injury, bdmf and spinal cord
12) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.53 Pain Relevance 0.71
After the beginning of tectal innervation, BDNF mRNA levels markedly increased, and optic stalk transection at day 4 (which prevents subsequent tectal innervation) was found to reduce the contralateral tectal levels of BDNF mRNA.
Negative_regulation (reduce) of Transcription (levels) of BDNF in optic stalk
13) Confidence 0.31 Published 1994 Journal Development Section Abstract Doc Link 8050370 Disease Relevance 0.22 Pain Relevance 0.10
This is in accordance with a study in rats showing that hyperoxia reduces mRNA levels for BDNF and three other neurotrophins [9].
Negative_regulation (reduces) of Transcription (levels) of BDNF associated with hyperoxia
14) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000320 Disease Relevance 0.86 Pain Relevance 0.10
In humans, BDNF mRNA levels were found to be highest in neonates and to decrease with age [18].
Negative_regulation (decrease) of Transcription (levels) of BDNF
15) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000320 Disease Relevance 1.13 Pain Relevance 0.28
The cooperation of BzATP with NMDA and BDNF was also reproduced at the level of the apoptotic inducer caspase-3.
Negative_regulation (reproduced) of Transcription (level) of BDNF associated with apoptosis
16) Confidence 0.27 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.10 Pain Relevance 0
This is based on two pieces of evidence. (1) BDNF expression and release from target neurons depends on GABAergic depolarization in the first 2 weeks in vitro, whereas GABAergic activity reduces the synthesis of BDNF mRNA in mature neurons (Berninger et al., 1995; Marty et al., 1996; Vicario-Abejon et al., 1998; Giusi et al., 2009). (2) BDNF signaling deprivation leads to dendrite growth impairment in newborn neurons during development and in the adult (McAllister et al., 1996; Berghuis et al., 2006; Chen et al., 2006; Takemoto-Kimura et al., 2007; Bergami et al., 2008; Chan et al., 2008; Ageta-Ishihara et al., 2009; Suh et al., 2009).
Negative_regulation (reduces) of Transcription (synthesis) of BDNF in neurons associated with gabaergic
17) Confidence 0.09 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2859806 Disease Relevance 0 Pain Relevance 0.20

General Comments

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