INT56048

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1994
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 24
Total Number 27
Disease Relevance 8.33
Pain Relevance 11.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
dentate gyrus 6
hippocampus 6
neurons 4
PC-12 2
brain 2
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 24 100.00 Very High Very High Very High
Nerve growth factor 17 100.00 Very High Very High Very High
Locus ceruleus 9 99.84 Very High Very High Very High
Hippocampus 168 99.82 Very High Very High Very High
Morphine 46 99.80 Very High Very High Very High
fluoxetine 95 99.64 Very High Very High Very High
Analgesic 8 99.44 Very High Very High Very High
withdrawal 20 99.16 Very High Very High Very High
dorsal root ganglion 16 99.08 Very High Very High Very High
tolerance 25 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 276 99.86 Very High Very High Very High
Ganglion Cysts 23 99.08 Very High Very High Very High
Anxiety Disorder 107 99.04 Very High Very High Very High
INFLAMMATION 19 96.58 Very High Very High Very High
Status Epilepticus 4 96.12 Very High Very High Very High
Nociception 29 95.20 Very High Very High Very High
Targeted Disruption 20 94.24 High High
Teratocarcinoma 1 92.76 High High
Mental Disorders 16 89.64 High High
Pain 33 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together with previous studies, our results support that exon IV-containing BDNF transcripts plays a pivotal role in the enhanced expression of total BDNF mRNA during the consolidation of contextual fear.
Positive_regulation (enhanced) of Transcription (expression) of BDNF associated with anxiety disorder
1) Confidence 0.70 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.44 Pain Relevance 0.11
With regard to emotional learning, such as fear conditioning (FC), Hall et al.27 reported that BDNF mRNA expression is upregulated in the hippocampal CA1 region 24 h after contextual FC, suggesting that BDNF signaling may contribute to synaptic plasticity in this form of learning.
Positive_regulation (upregulated) of Transcription (expression) of BDNF associated with anxiety disorder
2) Confidence 0.70 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.94 Pain Relevance 0.08
Daily administration of the CREB-binding protein inhibitor curcumin abolished the upregulation of BDNF transcription and morphine analgesic tolerance.
Positive_regulation (upregulation) of Transcription (transcription) of BDNF associated with analgesic, tolerance and morphine
3) Confidence 0.58 Published 2009 Journal Neuroreport Section Abstract Doc Link 19033880 Disease Relevance 0 Pain Relevance 1.09
To our knowledge, only 2 studies have examined the regulatory effect of histone acetylation on the expression of BDNF mRNA in the rat hippocampus after an acute stimulation.15,20 In response to pilocarpine-induced status epilepticus, increased levels of exon I and IV of the BDNF gene were, at least in part, derived from the hyperacetylation of histone H4 at the P2 promoter and deacetylation of histone H4 associated with the P4 promoter.20 Likewise, the marked increase in histone H4 acetylation, but not histone H3 acetylation, at the P2 promoter of the BDNF gene correlated with an increase in total BDNF mRNA in the rat hippocampus 2 h after electroconvulsive seizure.15 In contrast with our study, these previous studies indicated the importance of histone H4 acetylation at the P2 promoter in the regulation of BDNF mRNA expression.
Spec (examined) Positive_regulation (examined) of Spec (examined) Transcription (expression) of BDNF in hippocampus associated with convulsion, status epilepticus and hippocampus
4) Confidence 0.50 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 0.61 Pain Relevance 0.22
Peripheral tissue inflammation produced by an intraplantar injection of Freund's adjuvant into the paws significantly increased BDNF mRNA levels in the DRG and many neurons expressing trkA mRNA showed increased expession of BDNF mRNA.
Positive_regulation (increased) of Transcription (expession) of BDNF mRNA in DRG associated with dorsal root ganglion and inflammation
5) Confidence 0.50 Published 1997 Journal Brain Res. Section Abstract Doc Link 9138740 Disease Relevance 0.84 Pain Relevance 0.74
These results suggest that venlafaxine and imipramine, but not fluoxetine, induce neuroplastic effects in the hippocampus through stimulation of BDNF mRNA expression, and that the effect on BDNF is not directly translated into regulation of synaptophysin and GAP-43 mRNA.
Positive_regulation (stimulation) of Transcription (expression) of BDNF in hippocampus associated with hippocampus and fluoxetine
6) Confidence 0.47 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17950272 Disease Relevance 0 Pain Relevance 0.60
BDNF mRNA levels in the dentate gyrus (DG) were increased after treatment with venlafaxine (7, 14 and 21 days) and imipramine (14 and 21 days), but not after treatment with fluoxetine, indicating that stimulation of BDNF mRNA expression is dependent on the pharmacological profile and on the time-course of drug treatment.
Positive_regulation (stimulation) of Transcription (expression) of BDNF in dentate gyrus associated with fluoxetine
7) Confidence 0.47 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17950272 Disease Relevance 0 Pain Relevance 0.71
BDNF mRNA levels in the dentate gyrus (DG) were increased after treatment with venlafaxine (7, 14 and 21 days) and imipramine (14 and 21 days), but not after treatment with fluoxetine, indicating that stimulation of BDNF mRNA expression is dependent on the pharmacological profile and on the time-course of drug treatment.
Positive_regulation (dependent) of Transcription (expression) of BDNF in dentate gyrus associated with fluoxetine
8) Confidence 0.47 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17950272 Disease Relevance 0 Pain Relevance 0.72
BDNF mRNA levels in the dentate gyrus (DG) were increased after treatment with venlafaxine (7, 14 and 21 days) and imipramine (14 and 21 days), but not after treatment with fluoxetine, indicating that stimulation of BDNF mRNA expression is dependent on the pharmacological profile and on the time-course of drug treatment.
Neg (not) Positive_regulation (increased) of Transcription (levels) of BDNF in dentate gyrus associated with fluoxetine
9) Confidence 0.47 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17950272 Disease Relevance 0 Pain Relevance 0.66
Levels of BDNF and trkB mRNAs were increased in the hippocampus in a dose-dependent fashion following the stimulations.
Positive_regulation (increased) of Transcription (Levels) of BDNF in hippocampus associated with hippocampus
10) Confidence 0.47 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9013789 Disease Relevance 0 Pain Relevance 0.72
However, BDNF gene expression was continuously up-regulated throughout the entire time course, with most robust response occurring at 21 days after three weekly (3×) injections of CFA (228% increase in BDNF mRNA levels when compared to sham controls).
Positive_regulation (increase) of Transcription (levels) of BDNF
11) Confidence 0.44 Published 2007 Journal Mol Pain Section Body Doc Link PMC2174921 Disease Relevance 0.50 Pain Relevance 0.37
incubated with a secondary antihuman BDNF polyclonal antibody for 2 hours
Positive_regulation (incubated) of Transcription (antibody) of BDNF
12) Confidence 0.43 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2442167 Disease Relevance 0 Pain Relevance 0
Previous studies have also shown that there are increased levels of BDNF protein and mRNA in rat treated with antidepressants [16], [18], [19].
Positive_regulation (increased) of Transcription (levels) of BDNF associated with antidepressant
13) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965105 Disease Relevance 0.73 Pain Relevance 0.46
In this paper, we review our latest findings regarding how different types of stress alter BDNF transcription mediated by differential usage of multiple promoters of BDNF regulated by histone acetylation status to generate region-specific expression and responses to stimuli.
Positive_regulation (mediated) of Transcription (transcription) of BDNF associated with stress
14) Confidence 0.41 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022311 Disease Relevance 1.08 Pain Relevance 0.12
The rodent BDNF gene is transcribed by multiple promoters and generates at least 22 different transcripts [30,31].
Positive_regulation (by) of Transcription (transcribed) of BDNF gene
15) Confidence 0.39 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.54 Pain Relevance 0
Chronic morphine treatment significantly increased the expression of exon I and IV BDNF transcripts, indicating differential regulation of BDNF gene expression.
Positive_regulation (increased) of Transcription (transcripts) of BDNF associated with morphine
16) Confidence 0.39 Published 2009 Journal Neuroreport Section Abstract Doc Link 19033880 Disease Relevance 0 Pain Relevance 1.06
RESULTS: Ischemia led to strong upregulation of mRNA transcripts for heat shock proteins 70, 27, 105, 86 and 40 kDa, vascular endothelial growth factor, brain-derived neurotrophic factor, plasminogen activator inhibitor-1, activating transcription factor 3, B-cell translocation gene 2, and growth arrest and DNA damage inducible 45 alpha protein compared to the NI tissue.
Positive_regulation (upregulation) of Transcription (transcripts) of brain-derived neurotrophic factor in brain
17) Confidence 0.39 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 12909328 Disease Relevance 0.15 Pain Relevance 0
A significant increase in the percentage of BDNF-IR neurons in the DRG was observed in the NP group at 3 days after surgery and the increase in BDNF mRNA expression was confirmed using in situ hybridization histochemistry and reverse transcription-polymerase chain reaction.
Positive_regulation (increase) of Transcription (expression) of BDNF in neurons associated with dorsal root ganglion
18) Confidence 0.38 Published 2002 Journal Pain Section Abstract Doc Link 12237190 Disease Relevance 0.92 Pain Relevance 0.96
COS 8 augmented the increase of nerve growth factor, brain-derived neurotrophic factor, and NT-3 mRNA expression in the distal stump of the axotomized sciatic nerve.
Positive_regulation (increase) of Transcription (expression) of brain-derived neurotrophic factor in nerve associated with nerve growth factor and sciatic nerve
19) Confidence 0.36 Published 1996 Journal J. Neurosci. Res. Section Abstract Doc Link 8951669 Disease Relevance 0.14 Pain Relevance 0.42
These results indicate that BDNF-induced striatal gene transcription requires calcium and TRPCs.


Positive_regulation (requires) of Transcription (transcription) of BDNF-induced
20) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2669182 Disease Relevance 0 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox