INT56053

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Context Info
Confidence 0.58
First Reported 1994
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 77
Total Number 81
Disease Relevance 64.40
Pain Relevance 26.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bdnf) cytoplasmic membrane-bounded vesicle (Bdnf)
Anatomy Link Frequency
hippocampus 13
brain 5
retina 4
cortex 4
neurons 4
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
bDMF 140 100.00 Very High Very High Very High
depression 2889 99.96 Very High Very High Very High
antidepressant 2535 99.90 Very High Very High Very High
Hippocampus 1587 99.68 Very High Very High Very High
Inflammation 132 99.32 Very High Very High Very High
Pain 24 99.16 Very High Very High Very High
Desipramine 327 99.04 Very High Very High Very High
qutenza 39 98.94 Very High Very High Very High
amygdala 219 98.68 Very High Very High Very High
B1 receptor 102 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 121 100.00 Very High Very High Very High
Repression 84 100.00 Very High Very High Very High
Diabetes Mellitus 894 99.98 Very High Very High Very High
Ganglion Cysts 95 99.98 Very High Very High Very High
Depression 3735 99.96 Very High Very High Very High
Suicidal Behaviour 3947 99.84 Very High Very High Very High
Stress 1200 99.82 Very High Very High Very High
Disease 606 99.70 Very High Very High Very High
Cognitive Disorder 210 99.68 Very High Very High Very High
Targeted Disruption 402 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several studies have shown that exposure of exogenous corticosterone (to mimic the stress effect) also reduces BDNF expression in rodent hippocampus, similar to that observed in various pre-clinical stress models.83,89–91 Recently, we examined the effects of corticosterone treatment on BDNF expression in detail and found that the mRNA level of BDNF was not only decreased in the hippocampus but that the frontal cortex also showed significantly reduced expression of BDNF.92 This suggests that the effects of glucocorticoids on BDNF are not limited to the hippocampus; other brain areas are also equally affected.
Negative_regulation (decreased) of BDNF in hippocampus associated with stress, urological neuroanatomy and hippocampus
1) Confidence 0.58 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.60 Pain Relevance 0.38
On the other hand, a decrease in BDNF mRNA was observed both in the PFC and hippocampus of teenaged suicide subjects.
Negative_regulation (decrease) of BDNF in hippocampus associated with suicidal behaviour and hippocampus
2) Confidence 0.58 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.09 Pain Relevance 0.24
However, in our capsaicin model, injection of the trkB-IgG fusion protein (an inhibitor of BDNF function [64]) into the area of secondary hyperalgesia (10 µg/50 ul, 4 h prior to capsaicin injection) had no effect on pinprick pain thresholds compared to vehicle controls (data not shown).


Negative_regulation (inhibitor) of BDNF associated with pain, hyperalgesia and qutenza
3) Confidence 0.57 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276314 Disease Relevance 0.45 Pain Relevance 0.63
They found that the selective loss of BDNF in the dentate gyrus, but not in the CA1 region of the hippocampus, attenuated the actions of desipramine and citalopram in the forced swim test.
Negative_regulation (loss) of BDNF in hippocampus associated with desipramine, eae and hippocampus
4) Confidence 0.51 Published 2010 Journal Psychiatry Investigation Section Body Doc Link PMC3022309 Disease Relevance 0.52 Pain Relevance 0.72
We investigated the role of BDNF signaling in antidepressant-induced neurogenesis by using transgenic mice with either reduced BDNF levels (BDNF+/-) or impaired trkB activation (trkB.T1-overexpressing mice).
Negative_regulation (reduced) of BDNF associated with targeted disruption, antidepressant and neurodegenerative disease
5) Confidence 0.51 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15689544 Disease Relevance 0.53 Pain Relevance 0.21
Therefore, the decrease in BDNF levels plays a key role in the specific pathology observed in Huntington's disease by inducing dysfunction of striatal enkephalinergic neurons that produce severe motor dysfunctions.
Negative_regulation (decrease) of BDNF in neurons associated with disease
6) Confidence 0.51 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15342740 Disease Relevance 0.55 Pain Relevance 0.13
In addition, Karege et al182 found that suicide subjects who were receiving antidepressant treatment did not show any change in the level of BDNF, suggesting that psychotropic drugs normalize the decreased level of BDNF in suicide subjects.
Negative_regulation (decreased) of BDNF associated with antidepressant and suicidal behaviour
7) Confidence 0.50 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.07 Pain Relevance 0.27
Although depression is an important factor in suicide, some studies were able to differentiate suicidal behavior vs depressive behavior in terms of decreased level of BDNF.
Negative_regulation (decreased) of BDNF associated with suicidal behaviour and depression
8) Confidence 0.50 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 2.18 Pain Relevance 0.33
From these studies, it can be assumed that a decrease in BDNF in suicide subjects is independent of psychiatric illness and stress diathesis; however, further studies will be required to answer this complex question.
Negative_regulation (decrease) of BDNF associated with disease susceptibility, stress, mental disorders and suicidal behaviour
9) Confidence 0.50 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 2.14 Pain Relevance 0.21
These studies suggest that reduction of plasma BDNF level is related to suicidal behavior in depression and that BDNF level may be a biological marker of suicidal depression.
Negative_regulation (reduction) of BDNF in plasma associated with suicidal behaviour and depression
10) Confidence 0.50 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.13 Pain Relevance 0.10
No change was found in the entorhinal cortex, suggesting that a decrease in BDNF may be specific only to certain brain areas.
Negative_regulation (decrease) of BDNF in cortex
11) Confidence 0.50 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.11 Pain Relevance 0.27
For example, Rasmusson et al86 demonstrated that exposure to twenty 0.5-second 0.4-mA foot shocks coterminating with 70-dB, 5-second-long pure tones over 60 minutes decreased dentate gyrus BDNF mRNA.
Negative_regulation (decreased) of BDNF in dentate gyrus associated with shock
12) Confidence 0.50 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.85 Pain Relevance 0.35
Similar to our findings, they reported that the level of BDNF was significantly decreased in the PFC and hippocampus.
Negative_regulation (decreased) of BDNF in hippocampus associated with hippocampus
13) Confidence 0.50 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.12 Pain Relevance 0.27
These reductions were associated with a significant decrease in the protein level of BDNF.
Negative_regulation (decrease) of BDNF
14) Confidence 0.50 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 1.40 Pain Relevance 0.31
Thus, the relationship between the loss of BDNF activity and the expression of depressive symptoms is not in a simple correlation.
Negative_regulation (loss) of BDNF associated with depression and bdmf
15) Confidence 0.48 Published 2010 Journal Mol Brain Section Body Doc Link PMC2848031 Disease Relevance 0.73 Pain Relevance 0.72
Diabetes-induced reduction in BDNF was suppressed by lutein intake Since diabetes decreases one of the major trophic factors for retinal neurons, BDNF, we also measured BDNF by immunoblot analysis in the 1-month-diabetic retina.
Negative_regulation (reduction) of BDNF in retina associated with diabetes mellitus
16) Confidence 0.45 Published 2010 Journal Diabetologia Section Body Doc Link PMC2850533 Disease Relevance 1.54 Pain Relevance 0
Thus, BDNF reduction may also have been involved in visual impairment shown by OPs in ERGs.
Negative_regulation (reduction) of BDNF
17) Confidence 0.45 Published 2010 Journal Diabetologia Section Body Doc Link PMC2850533 Disease Relevance 0.72 Pain Relevance 0.05
Importantly, the decrease in BDNF caused by diabetes was attenuated by constant intake of the lutein-supplemented diet (Fig. 3c, f).
Negative_regulation (decrease) of BDNF associated with diabetes mellitus
18) Confidence 0.45 Published 2010 Journal Diabetologia Section Body Doc Link PMC2850533 Disease Relevance 1.27 Pain Relevance 0
For bladder reactivity, BDNF deficiency leads to lower sensitization in inflammatory state but has no effect in control state.
Negative_regulation (deficiency) of BDNF in bladder associated with inflammation
19) Confidence 0.43 Published 2010 Journal Eur J Pain Section Abstract Doc Link 19932037 Disease Relevance 1.04 Pain Relevance 0.49
Moreover, the antidepressant-induced increase in the surviving BrdU-positive neurons seen in wild-type mice 3 weeks after treatment was essentially lost in mice with reduced BDNF signaling.
Negative_regulation (reduced) of BDNF in neurons associated with antidepressant
20) Confidence 0.43 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15689544 Disease Relevance 0.50 Pain Relevance 0.37

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