INT56054

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Context Info
Confidence 0.59
First Reported 1994
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.75
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
neurons 2
brain 1
sympathetic 1
petrosal ganglion 1
Ntf3 (Mus musculus)
Pain Link Frequency Relevance Heat
neurotrophin 3 8 100.00 Very High Very High Very High
Calcium channel 4 99.76 Very High Very High Very High
long-term potentiation 3 99.28 Very High Very High Very High
bDMF 98 98.96 Very High Very High Very High
Central nervous system 11 92.48 High High
Pyramidal cell 7 92.48 High High
tetrodotoxin 1 91.76 High High
Mechanosensation 1 88.84 High High
Pain 4 85.76 High High
addiction 6 81.92 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 12 99.72 Very High Very High Very High
Death 24 99.16 Very High Very High Very High
Infection 48 98.48 Very High Very High Very High
Dyskinesias 3 97.96 Very High Very High Very High
Ganglion Cysts 89 97.52 Very High Very High Very High
Apoptosis 11 95.36 Very High Very High Very High
Pain 4 85.76 High High
Cytomegalovirus Infection 56 83.52 Quite High
Intellectual Impairment 3 59.36 Quite High
Neurodegenerative Disease 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, voltage-gated calcium channel inhibition downregulates the extracellular levels of NT-3 in high-density cultures.
Negative_regulation (downregulates) of NT-3 associated with calcium channel
1) Confidence 0.59 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11698591 Disease Relevance 0 Pain Relevance 0.43
Mice deficient for neurotrophin-3 (NT-3) and its receptor, encoded by the trkC gene, show abnormal movements caused by the loss of sensory proprioceptive neurons.
Negative_regulation (deficient) of neurotrophin-3 in neurons associated with dyskinesias
2) Confidence 0.37 Published 1994 Journal FASEB J. Section Abstract Doc Link 8050673 Disease Relevance 0.25 Pain Relevance 0.13
Mice deficient for neurotrophin-3 (NT-3) and its receptor, encoded by the trkC gene, show abnormal movements caused by the loss of sensory proprioceptive neurons.
Negative_regulation (deficient) of NT-3 in neurons associated with dyskinesias
3) Confidence 0.37 Published 1994 Journal FASEB J. Section Abstract Doc Link 8050673 Disease Relevance 0.25 Pain Relevance 0.13
In this case, removal of either neurotrophin would result in the death of this subpopulation.
Negative_regulation (removal) of neurotrophin associated with death
4) Confidence 0.36 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.37 Pain Relevance 0.29
Mice lacking NT3 (encoded by the Ntf3 gene) lose about 47% of the neurons in the geniculate ganglion and 44% in the nodose/petrosal ganglion complex [44].
Negative_regulation (lacking) of NT3 in petrosal ganglion associated with ganglion cysts
5) Confidence 0.36 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.35 Pain Relevance 0.25
Down-regulation of the gene encoding of the neurotrophin NT3 was also associated with viral brain infection.
Negative_regulation (regulation) of neurotrophin NT3 in brain associated with neurotrophin 3 and infection
6) Confidence 0.34 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 1.13 Pain Relevance 0.19
NT-3 deficiency also causes a decrease in the number of sympathetic cervical ganglion neurons, lingual innervations, and sensory neuron precursor cells [19,20].
Negative_regulation (deficiency) of NT-3 in sympathetic associated with ganglion cysts
7) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.40 Pain Relevance 0.44

General Comments

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