INT56060

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Context Info
Confidence 0.05
First Reported 1993
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.76
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RTCA) RNA binding (RTCA) nucleus (RTCA)
ligase activity (RTCA)
Anatomy Link Frequency
frontal cortex 1
RTCA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 3 96.68 Very High Very High Very High
narcan 3 89.96 High High
antagonist 1 85.36 High High
opiate 3 84.92 Quite High
Morphine 4 84.00 Quite High
adenocard 1 80.68 Quite High
Sumatriptan 1 79.24 Quite High
Enkephalin 3 78.04 Quite High
Opioid receptor 1 2 75.00 Quite High
drug abuse 57 69.72 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 98.80 Very High Very High Very High
Bordatella Infection 2 96.00 Very High Very High Very High
Obesity 4 78.92 Quite High
Cardiovascular Disease 9 77.76 Quite High
Stress 3 76.72 Quite High
Drug Dependence 58 69.72 Quite High
Pain 1 52.64 Quite High
Overweight 4 16.80 Low Low
Disorder Of Lipid Metabolism 5 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TM VI histidine substitution with alanine yielded a receptor that produced almost twice the cyclase inhibition displayed by the wild type receptor in parallel transient expression assays.
Gene_expression (produced) of cyclase
1) Confidence 0.05 Published 1994 Journal J. Biol. Chem. Section Abstract Doc Link 8051154 Disease Relevance 0.05 Pain Relevance 0.94
Thus both 5-HT1D receptors activate markedly Gi and to a lesser extent Gs and can exert opposite effects on the same effector system, adenylate cyclase.
Gene_expression (activate) of cyclase
2) Confidence 0.03 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8282007 Disease Relevance 0.18 Pain Relevance 0.15
Studies in human postmortem brain have previously demonstrated a general decrease in calcium/cAMP-related signaling transcripts in frontal and motor cortex of human alcoholics [13], a decrease in adenylate cyclase (AC) type I (AC-I) protein levels and activity in temporal and frontal cortex in alcoholics [22]–[23] and in AC-I mRNA and protein in temporal cortex from heroin addicts [24].
Gene_expression (levels) of cyclase in frontal cortex associated with urological neuroanatomy
3) Confidence 0.02 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762434 Disease Relevance 0.53 Pain Relevance 0.18

General Comments

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