INT56073

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Context Info
Confidence 0.46
First Reported 1994
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.88
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
T cells 2
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 4 99.68 Very High Very High Very High
Inflammatory response 1 99.50 Very High Very High Very High
COX-2 inhibitor 3 95.76 Very High Very High Very High
Inflammation 3 91.52 High High
peptic ulcer disease 1 90.20 High High
cINOD 6 87.40 High High
cytokine 2 25.00 Low Low
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 8 99.32 Very High Very High Very High
Infection 4 98.56 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 98.56 Very High Very High Very High
Adenocarcinoma 2 90.96 High High
Disease 1 90.20 High High
Ulcers 1 89.88 High High
Gastritis 4 89.32 High High
Adhesions 1 85.84 High High
Apoptosis 2 84.96 Quite High
Breast Cancer 2 56.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sodium salicylate and aspirin also inhibited NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.
Positive_regulation (dependent) of Transcription (transcription) of NF-kappa B in T cells associated with aspirin and acquired immune deficiency syndrome or hiv infection
1) Confidence 0.46 Published 1994 Journal Science Section Abstract Doc Link 8052854 Disease Relevance 0.54 Pain Relevance 0.26
We found that celecoxib and PSC833, but not indomethacin or NS398, almost completely inhibited basal- and dox induced NF-kappaB gene-reporter activity and p65 subunit nuclear translocation.
Positive_regulation (induced) of Transcription (activity) of NF-kappaB
2) Confidence 0.46 Published 2007 Journal Eur. J. Cancer Section Abstract Doc Link 17097285 Disease Relevance 0.06 Pain Relevance 0.12
Moreover, induced transcription from NF-kappaB- and NF-AT-dependent enhancers was also inhibited.
Positive_regulation (induced) of Transcription (transcription) of NF-kappaB
3) Confidence 0.40 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.16 Pain Relevance 0.25
H. pylori-induced damage to gastric mucosal cells is controlled by bacterial virulence factors encoded by genes of the cag pathogenicity island, which trigger the inflammatory response of the host through the activation of nuclear factor kappaB-dependent gene transcription.
Positive_regulation (activation) of Transcription (transcription) of nuclear factor kappaB-dependent associated with inflammatory response
4) Confidence 0.17 Published 1999 Journal Cell. Microbiol. Section Abstract Doc Link 11207544 Disease Relevance 1.13 Pain Relevance 0.14

General Comments

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