INT56074

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Context Info
Confidence 0.58
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.53
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
T cells 2
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 4 99.88 Very High Very High Very High
Inflammation 2 95.52 Very High Very High Very High
COX-2 inhibitor 1 95.44 Very High Very High Very High
cINOD 5 90.64 High High
COX2 4 25.00 Low Low
cytokine 1 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 98.56 Very High Very High Very High
Apoptosis 5 96.72 Very High Very High Very High
INFLAMMATION 6 95.52 Very High Very High Very High
Adhesions 1 86.24 High High
Infection 1 84.20 Quite High
Esophageal Cancer 2 75.00 Quite High
Skin Cancer 1 74.64 Quite High
Cancer 2 67.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sodium salicylate and aspirin also inhibited NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.
Negative_regulation (inhibited) of Transcription (transcription) of NF-kappa B in T cells associated with aspirin and acquired immune deficiency syndrome or hiv infection
1) Confidence 0.58 Published 1994 Journal Science Section Abstract Doc Link 8052854 Disease Relevance 0.54 Pain Relevance 0.26
NS-398 dose-dependently decreased the levels of COX-2 mRNA, COX-2 protein, nuclear NF-kappaB protein and production of PGF(1alpha) and increased the cytoplasmic IkappaB protein.
Negative_regulation (decreased) of Transcription (levels) of nuclear NF-kappaB protein
2) Confidence 0.34 Published 2009 Journal Cancer Invest. Section Abstract Doc Link 19160097 Disease Relevance 0.83 Pain Relevance 0.13
Moreover, induced transcription from NF-kappaB- and NF-AT-dependent enhancers was also inhibited.
Negative_regulation (inhibited) of Transcription (transcription) of NF-kappaB
3) Confidence 0.25 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.16 Pain Relevance 0.25

General Comments

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