INT56075

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.71
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 9.03
Pain Relevance 3.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
T-cell 4
spinal cord neurons 1
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 44 99.98 Very High Very High Very High
aspirin 4 99.68 Very High Very High Very High
chemokine 9 99.66 Very High Very High Very High
Endogenous opioid 1 99.40 Very High Very High Very High
cytokine 37 99.22 Very High Very High Very High
Inflammatory response 5 99.22 Very High Very High Very High
Morphine 3 98.88 Very High Very High Very High
Spinal cord 3 97.24 Very High Very High Very High
Arthritis 106 96.72 Very High Very High Very High
COX-2 inhibitor 3 95.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 55 99.98 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 150 98.56 Very High Very High Very High
Infection 17 98.56 Very High Very High Very High
Disease 35 97.92 Very High Very High Very High
Rheumatoid Arthritis 103 96.72 Very High Very High Very High
Stress 35 96.48 Very High Very High Very High
Apoptosis 25 96.16 Very High Very High Very High
Traumatic Stress Disorders 1 94.48 High High
Cancer 27 90.92 High High
Adenocarcinoma 2 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sodium salicylate and aspirin also inhibited NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.
Transcription (transcription) of NF-kappa B in T cells associated with aspirin and acquired immune deficiency syndrome or hiv infection
1) Confidence 0.71 Published 1994 Journal Science Section Abstract Doc Link 8052854 Disease Relevance 0.54 Pain Relevance 0.26
The pro-inflammatory transcription factor NF-kappa B (NF-?
Transcription (transcription) of NF-kappa B associated with inflammation
2) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2432467 Disease Relevance 1.69 Pain Relevance 0.33
Given these possible harmful outcomes, a range of novel therapeutically relevant biological targets that include nuclear transcription factor (NF-kappaB), p38 mitogen-activated protein kinases (MAPK) and Janus protein tyrosine kinases and signal transducers and activators of transcription (JAK/STAT) signalling pathways has received growing attention.
Transcription (transcription) of NF-kappaB
3) Confidence 0.67 Published 2008 Journal Drugs R D Section Abstract Doc Link 18989991 Disease Relevance 0.53 Pain Relevance 0.34
We found that celecoxib and PSC833, but not indomethacin or NS398, almost completely inhibited basal- and dox induced NF-kappaB gene-reporter activity and p65 subunit nuclear translocation.
Transcription (activity) of NF-kappaB
4) Confidence 0.63 Published 2007 Journal Eur. J. Cancer Section Abstract Doc Link 17097285 Disease Relevance 0.06 Pain Relevance 0.12
NS-398 dose-dependently decreased the levels of COX-2 mRNA, COX-2 protein, nuclear NF-kappaB protein and production of PGF(1alpha) and increased the cytoplasmic IkappaB protein.
Transcription (levels) of nuclear NF-kappaB protein
5) Confidence 0.55 Published 2009 Journal Cancer Invest. Section Abstract Doc Link 19160097 Disease Relevance 0.82 Pain Relevance 0.13
We identify 5 transcription factors in the global interaction network: FOS, FOXO1, NFAT5, NFKB1 and TP53.
Transcription (transcription) of NFKB1
6) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 1.20 Pain Relevance 0.35
Vpr has effects on T-cell proliferation, cytokine production, chemokine production, and Nuclear Factor kappa B (NF-kappaB)-mediated transcription.
Transcription (transcription) of Nuclear Factor kappa B in T-cell associated with chemokine and cytokine
7) Confidence 0.50 Published 2004 Journal DNA Cell Biol. Section Abstract Doc Link 15142381 Disease Relevance 0.99 Pain Relevance 0.38
Vpr has effects on T-cell proliferation, cytokine production, chemokine production, and Nuclear Factor kappa B (NF-kappaB)-mediated transcription.
Transcription (transcription) of NF-kappaB in T-cell associated with chemokine and cytokine
8) Confidence 0.50 Published 2004 Journal DNA Cell Biol. Section Abstract Doc Link 15142381 Disease Relevance 0.99 Pain Relevance 0.38
Moreover, induced transcription from NF-kappaB- and NF-AT-dependent enhancers was also inhibited.
Transcription (transcription) of NF-kappaB
9) Confidence 0.41 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10384106 Disease Relevance 0.16 Pain Relevance 0.25
Host transcription factors such as the Sp family, nuclear factor kappa B (NF-?
Transcription (transcription) of nuclear factor kappa B
10) Confidence 0.40 Published 2009 Journal Retrovirology Section Body Doc Link PMC2805609 Disease Relevance 0.55 Pain Relevance 0.08
H. pylori-induced damage to gastric mucosal cells is controlled by bacterial virulence factors encoded by genes of the cag pathogenicity island, which trigger the inflammatory response of the host through the activation of nuclear factor kappaB-dependent gene transcription.
Transcription (transcription) of nuclear factor kappaB-dependent associated with inflammatory response
11) Confidence 0.18 Published 1999 Journal Cell. Microbiol. Section Abstract Doc Link 11207544 Disease Relevance 1.12 Pain Relevance 0.14
We demonstrated that morphine and the endogenous opioid beta-endorphin inhibited the transcription of IL-2 in activated human T lymphocytes as well as the activation of the transcription factors AP-1, NFAT, and NF-kappaB, which transactivate IL-2.
Transcription (transcription) of NF-kappaB in T lymphocytes associated with endogenous opioid and morphine
12) Confidence 0.16 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19561113 Disease Relevance 0.26 Pain Relevance 0.86
Middle and high NF subunit (NFH) mRNA levels were not significantly different from polyadenylated mRNA levels in spinal cord neurons in aluminum-treated/control animals.
Transcription (levels) of NF subunit in spinal cord neurons associated with spinal cord
13) Confidence 0.04 Published 1997 Journal Neurotoxicology Section Abstract Doc Link 9215990 Disease Relevance 0.13 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox