INT56077

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Context Info
Confidence 0.98
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 8.03
Pain Relevance 3.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
T98G 1
nucleus 1
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 6 98.76 Very High Very High Very High
aspirin 30 98.16 Very High Very High Very High
Inflammation 96 94.56 High High
cINOD 8 93.44 High High
cytokine 66 90.72 High High
Inflammatory mediators 10 85.40 High High
Analgesic 1 78.92 Quite High
COX-2 inhibitor 4 78.36 Quite High
Osteoarthritis 5 75.00 Quite High
anesthesia 2 74.88 Quite High
Disease Link Frequency Relevance Heat
Multiple Myeloma 15 99.16 Very High Very High Very High
Cancer 31 98.44 Very High Very High Very High
Necrosis 9 98.20 Very High Very High Very High
Apoptosis 21 97.96 Very High Very High Very High
Bone Disease 15 96.08 Very High Very High Very High
INFLAMMATION 136 94.56 High High
Dementia 9 94.40 High High
Muscle Disease 1 93.00 High High
Adhesions 9 91.88 High High
Syndrome 3 91.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This inhibition prevented the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B was retained in the cytosol.
Protein_catabolism (degradation) of NF-kappa B
1) Confidence 0.98 Published 1994 Journal Science Section Abstract Doc Link 8052854 Disease Relevance 0.36 Pain Relevance 0.27
Salicylates have been shown to inhibit lipopolysaccharide-induced gene transcription via inhibition of NF-kappa B activation by preventing the degradation of NF-kappa B inhibitor "I kappa B", blocking the translocation of NF-kappa B into the nuclear compartment.
Protein_catabolism (degradation) of NF-kappa B
2) Confidence 0.98 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.49 Pain Relevance 0.29
This inhibition prevented the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B was retained in the cytosol.
Protein_catabolism (degradation) of NF-kappa B
3) Confidence 0.87 Published 1994 Journal Science Section Abstract Doc Link 8052854 Disease Relevance 0.36 Pain Relevance 0.27
These inhibitions appeared to correlate with the suppression of NF-kappaB activation by harpagoside, as pre-treating cells with harpagoside blocked the translocation of NF-kappaB into the nuclear compartments and degradation of the inhibitory subunit IkappaB-alpha.
Protein_catabolism (degradation) of NF-kappaB
4) Confidence 0.84 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16203115 Disease Relevance 0.23 Pain Relevance 0.32
Western blot analysis was done to assess nuclear factor kappaB activation by measuring degradation of the inhibitory subunit of the nuclear factor kappaB complex.
Protein_catabolism (degradation) of kappaB
5) Confidence 0.78 Published 2002 Journal J. Urol. Section Body Doc Link 12050558 Disease Relevance 0 Pain Relevance 0
B degradation as well as p50 and p65 translocation into nucleus.
Protein_catabolism (degradation) of p50 in nucleus
6) Confidence 0.69 Published 2007 Journal Mediators of Inflammation Section Abstract Doc Link PMC1874678 Disease Relevance 0.16 Pain Relevance 0
This gene encodes VCP, which has a role in targeting the inhibitor of NFkappaB for degradation by the proteasome.
Protein_catabolism (degradation) of NFkappaB
7) Confidence 0.64 Published 2006 Journal Nature clinical practice. Rheumatology Section Abstract Doc Link 16932700 Disease Relevance 1.45 Pain Relevance 0.05
Western blot analyses revealed that hCG-A impaired TNF-alpha-mediated phosphorylation and degradation of the inhibitor IkappaBalpha suggesting that the hormone may reduce nuclear import of NF-kappaB by stabilizing its inhibitor.
Protein_catabolism (degradation) of NF-kappaB
8) Confidence 0.61 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.29 Pain Relevance 0.20
SDX-308 effectively suppressed TNF-alpha-induced IKK-gamma and IkappaB-alpha phosphorylation and degradation and subsequent NF-kappaB activation in human multiple myeloma cells.
Protein_catabolism (degradation) of NF-kappaB associated with multiple myeloma
9) Confidence 0.53 Published 2007 Journal Blood Section Abstract Doc Link 17095620 Disease Relevance 0.87 Pain Relevance 0.11
Resveratrol, like N-Ac-Leu-Leu-norleucinal (ALLN) suppressed IL-1beta-induced proteasome function and the degradation of IkappaBalpha (an inhibitor of NF-kappaB) without affecting IkappaBalpha kinase activation, IkappaBalpha-phosphorylation or IkappaBalpha-ubiquitination which suppressed nuclear translocation of the p65 subunit of NF-kappaB and its phosphorylation.
Protein_catabolism (degradation) of NF-kappaB
10) Confidence 0.53 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18606398 Disease Relevance 1.16 Pain Relevance 0.38
Western blot analysis of IkappaBalpha protein in the cytoplasm of IL-1beta-stimulated T98G cells and electrophoretic mobility shift assay (EMSA) on corresponding nuclear extracts indicate that acetaminophen (10-1000 microM) dose-dependently inhibits both IkappaBalpha degradation and NF-kappaB nuclear translocation.
Protein_catabolism (degradation) of NF-kappaB in T98G associated with paracetamol
11) Confidence 0.49 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14664905 Disease Relevance 0 Pain Relevance 0.47
Data of Western blot further demonstrated that aspirin treatment caused activation of caspases, down-regulation of Mcl-1 protein, dephosphorylation of ERK-1/2 and AKT, and also IkappaB-alpha proteolysis-dependent NF-kappaB activation in YD-8 cells.
Protein_catabolism (proteolysis) of NF-kappaB associated with aspirin
12) Confidence 0.47 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.63 Pain Relevance 0.64
These findings collectively suggest that aspirin induces apoptosis in YD-8 cells and the induction may be correlated to activation of caspases, caspase-dependent Mcl-1 proteolysis, inactivation of ERK-1/2 and AKT, and activation of NF-kappaB.
Protein_catabolism (proteolysis) of NF-kappaB associated with aspirin and apoptosis
13) Confidence 0.47 Published 2010 Journal Toxicol In Vitro Section Abstract Doc Link 20116423 Disease Relevance 0.59 Pain Relevance 0.56
GLNVA also reduced cyclooxygenase (COX)-2 expression, inhibitor of nuclear factor (NF)-kappaB (IkappaB)alpha/IkappaBbeta degradation, NF-kappaB activation, and the overproduction of tumor necrosis factor-alpha, interleukin (IL)-1beta, and prostaglandin E2 in BV-2 cells.
Protein_catabolism (degradation) of NF-kappaB associated with necrosis and cancer
14) Confidence 0.36 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.94 Pain Relevance 0.15
B p65 and p50 grades among various groups were conducted by using Mann-Whitney U test.
Protein_catabolism (grades) of p50
15) Confidence 0.13 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2222592 Disease Relevance 0.36 Pain Relevance 0.16
In one study Ang II treatment induced IL-6 transcription by inducing cytoplasmic-to-nuclear translocation of the NF-kappaB subunits Rel A and NF-kappaB1 with parallel changes in DNA-binding activity in a biphasic manner, which produced an early peak at 15 minutes followed by a nadir 1 to 6 hours later and a later peak at 24 hours [60].


Protein_catabolism (subunits) of NF-kappaB
16) Confidence 0.13 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.14 Pain Relevance 0.07

General Comments

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