INT56078

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Context Info
Confidence 0.42
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.44
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 8 95.84 Very High Very High Very High
Inflammation 11 94.56 High High
cINOD 3 94.00 High High
cytokine 11 90.72 High High
Inflammatory mediators 4 86.00 High High
Analgesic 1 80.08 Quite High
Osteoarthritis 5 75.40 Quite High
Pain 5 74.64 Quite High
endometriosis 1 49.12 Quite Low
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Bone Disease 12 96.08 Very High Very High Very High
Dementia 1 94.92 High High
INFLAMMATION 18 94.56 High High
Muscle Disease 1 93.52 High High
Adhesions 2 92.44 High High
Syndrome 2 92.00 High High
Infection 2 90.40 High High
Arthritis 2 81.44 Quite High
Apoptosis 3 76.56 Quite High
Osteoarthritis 5 75.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This inhibition prevented the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B was retained in the cytosol.
Negative_regulation (prevented) of Protein_catabolism (degradation) of NF-kappa B
1) Confidence 0.42 Published 1994 Journal Science Section Abstract Doc Link 8052854 Disease Relevance 0.37 Pain Relevance 0.27
This inhibition prevented the degradation of the NF-kappa B inhibitor, I kappa B, and therefore NF-kappa B was retained in the cytosol.
Negative_regulation (prevented) of Protein_catabolism (degradation) of NF-kappa B
2) Confidence 0.42 Published 1994 Journal Science Section Abstract Doc Link 8052854 Disease Relevance 0.37 Pain Relevance 0.27
Salicylates have been shown to inhibit lipopolysaccharide-induced gene transcription via inhibition of NF-kappa B activation by preventing the degradation of NF-kappa B inhibitor "I kappa B", blocking the translocation of NF-kappa B into the nuclear compartment.
Negative_regulation (preventing) of Protein_catabolism (degradation) of NF-kappa B
3) Confidence 0.42 Published 1996 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 9467376 Disease Relevance 0.49 Pain Relevance 0.30
This gene encodes VCP, which has a role in targeting the inhibitor of NFkappaB for degradation by the proteasome.
Negative_regulation (inhibitor) of Protein_catabolism (degradation) of NFkappaB
4) Confidence 0.42 Published 2006 Journal Nature clinical practice. Rheumatology Section Abstract Doc Link 16932700 Disease Relevance 1.46 Pain Relevance 0.05
These inhibitions appeared to correlate with the suppression of NF-kappaB activation by harpagoside, as pre-treating cells with harpagoside blocked the translocation of NF-kappaB into the nuclear compartments and degradation of the inhibitory subunit IkappaB-alpha.
Negative_regulation (blocked) of Protein_catabolism (degradation) of NF-kappaB
5) Confidence 0.41 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16203115 Disease Relevance 0.23 Pain Relevance 0.32
Western blot analyses revealed that hCG-A impaired TNF-alpha-mediated phosphorylation and degradation of the inhibitor IkappaBalpha suggesting that the hormone may reduce nuclear import of NF-kappaB by stabilizing its inhibitor.
Negative_regulation (impaired) of Protein_catabolism (degradation) of NF-kappaB
6) Confidence 0.40 Published 2007 Journal Mol. Hum. Reprod. Section Abstract Doc Link 17525069 Disease Relevance 0.35 Pain Relevance 0.22
Resveratrol, like N-Ac-Leu-Leu-norleucinal (ALLN) suppressed IL-1beta-induced proteasome function and the degradation of IkappaBalpha (an inhibitor of NF-kappaB) without affecting IkappaBalpha kinase activation, IkappaBalpha-phosphorylation or IkappaBalpha-ubiquitination which suppressed nuclear translocation of the p65 subunit of NF-kappaB and its phosphorylation.
Negative_regulation (suppressed) of Protein_catabolism (degradation) of NF-kappaB
7) Confidence 0.35 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18606398 Disease Relevance 1.18 Pain Relevance 0.39

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