INT56080

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Context Info
Confidence 0.40
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 2.16
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFKBIA) plasma membrane (NFKBIA) nucleus (NFKBIA)
enzyme binding (NFKBIA) transcription factor binding (NFKBIA) cytoplasm (NFKBIA)
Anatomy Link Frequency
T cells 1
NFKBIA (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 4 99.26 Very High Very High Very High
corticosteroid 280 98.58 Very High Very High Very High
Inflammatory response 285 96.44 Very High Very High Very High
Inflammation 436 94.08 High High
cytokine 65 92.04 High High
cINOD 11 86.56 High High
Inflammatory stimuli 175 82.36 Quite High
Inflammatory mediators 20 5.00 Very Low Very Low Very Low
tolerance 5 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 99.64 Very High Very High Very High
INFLAMMATION 772 96.44 Very High Very High Very High
Adhesions 1 85.00 Quite High
Infection 6 82.96 Quite High
Disease 30 61.56 Quite High
Stress 5 16.96 Low Low
Systemic Inflammatory Response Syndrome 20 5.00 Very Low Very Low Very Low
Injury 15 5.00 Very Low Very Low Very Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Bacterial Infection 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our model, due to our hypothesis that the drug stimulates the transcription rate of IkBa, it is expected to observe the solid trajectories of Figure 12 which simulate decreased inflammatory responses (P, A, E).
Transcription (transcription) of IkBa associated with inflammatory response
1) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.60 Pain Relevance 0.57
The dynamics of the gene transcript of IKBa (mRNA,IKBa), (2c), are characterized by a zero order production rate (Kin,IkBa) and a first order degradation rate (Kout,IkBa) which is stimulated by NFkB [36].
Transcription (transcript) of IKBa
2) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.19 Pain Relevance 0.09
The dynamics of the gene transcript of IKBa (mRNA,IKBa), (2c), are characterized by a zero order production rate (Kin,IkBa) and a first order degradation rate (Kout,IkBa) which is stimulated by NFkB [36].
Transcription (transcript) of IKBa
3) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.19 Pain Relevance 0.09
Given, therefore, a quantification of the dynamics of corticosteroids and putative modes of action of CS in regulating the activity of NFkB [73], [74] we test the hypothesis that corticosteroids exert their immunosuppressive effect by enhancing the transcriptional synthesis of NF-kB's inhibitor IkBa (mRNA,IkBa).
Transcription (synthesis) of IkBa associated with corticosteroid
4) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.32 Pain Relevance 0.46
Given, therefore, a quantification of the dynamics of corticosteroids and putative modes of action of CS in regulating the activity of NFkB [73], [74] we test the hypothesis that corticosteroids exert their immunosuppressive effect by enhancing the transcriptional synthesis of NF-kB's inhibitor IkBa (mRNA,IkBa).
Transcription (synthesis) of IkBa associated with corticosteroid
5) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.32 Pain Relevance 0.46
Sodium salicylate and aspirin also inhibited NF-kappa B-dependent transcription from the Ig kappa enhancer and the human immunodeficiency virus (HIV) long terminal repeat (LTR) in transfected T cells.
Transcription (transcription) of Ig kappa enhancer in T cells associated with aspirin and acquired immune deficiency syndrome or hiv infection
6) Confidence 0.09 Published 1994 Journal Science Section Abstract Doc Link 8052854 Disease Relevance 0.53 Pain Relevance 0.26

General Comments

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