INT56089

Context Info Confidence 0.41 First Reported 1994 Last Reported 1994 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.41 Pain Relevance 0.33

extracellular space (TGFB1, SERPINE1) extracellular region (TGFB1, SERPINE1) aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1) cytoplasm (TGFB1)

TGFB1 (Homo sapiens) SERPINE1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 7 94.56 cINOD 1 74.96 dexamethasone 1 71.60 Arthritis 1 38.80

Disease Link Frequency Relevance Heat Necrosis 2 90.76 Cancer 2 90.40 INFLAMMATION 1 74.56 Disease 1 5.00 Arthritis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The effects of TNF alpha and TGF-beta on PAI-1 antigen levels were both time- and concentration-dependent; optimum doses being 10-100 pM TNF alpha and 0.4-0.8 nM TGF-beta, with each cytokine exerting its effect on PAI-1 antigen levels within 8 h of addition to culture.

TGF-beta Regulation (effects) of PAI-1 associated with cytokine

1) Confidence 0.41 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 8054359 Disease Relevance 0.41 Pain Relevance 0.33

General Comments

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