INT5609

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Context Info
Confidence 0.60
First Reported 1992
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.73
Pain Relevance 3.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
epithelial cell 1
T cells 1
Ifx (Mus musculus)
Pain Link Frequency Relevance Heat
Infliximab 137 100.00 Very High Very High Very High
Etanercept 103 99.84 Very High Very High Very High
Morphine 8 99.82 Very High Very High Very High
Adalimumab 56 99.80 Very High Very High Very High
Crohn's disease 28 98.92 Very High Very High Very High
antagonist 50 98.52 Very High Very High Very High
chemokine 7 96.28 Very High Very High Very High
cytokine 69 95.20 Very High Very High Very High
cINOD 4 90.52 High High
Arthritis 58 90.12 High High
Disease Link Frequency Relevance Heat
Cold Sores 374 100.00 Very High Very High Very High
Infection 70 99.36 Very High Very High Very High
Disease 80 98.92 Very High Very High Very High
Contracture 10 96.84 Very High Very High Very High
Herpes Simplex Virus 10 96.28 Very High Very High Very High
Apoptosis 126 95.88 Very High Very High Very High
Ileitis 2 92.36 High High
Seronegative Spondarthritis 54 90.12 High High
INFLAMMATION 35 89.80 High High
Psoriasis 9 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Control of HSV-1 during primary infection requires recruitment of PMNLs macrophages and NK cells by specific chemokines, and culminates in the induction of antigen specific responses by T cells which control viral replication through lysis of infected cells and cytokine production.
Regulation (Control) of HSV-1 in T cells associated with chemokine, cold sores, infection and cytokine
1) Confidence 0.60 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.47 Pain Relevance 0.25
Effect of ibuprofen on the in vitro and in vivo reactivation of latent HSV-1.
Regulation (Effect) of HSV-1 associated with cold sores
2) Confidence 0.44 Published 1992 Journal Oral Surg. Oral Med. Oral Pathol. Section Title Doc Link 1312234 Disease Relevance 0.49 Pain Relevance 0.09
Further, 1.0 microM morphine did not effect the replication rate of HSV-1 in Vero cells.
Neg (not) Regulation (effect) of HSV-1 associated with cold sores and morphine
3) Confidence 0.44 Published 2001 Journal Int. J. Mol. Med. Section Abstract Doc Link 11494059 Disease Relevance 0.50 Pain Relevance 0.61
Our findings agree both with a recent paper by Zeissig and coll 10 who investigated the effects of IFX treatment in vivo on colonic mucosa in CD patients showing a significant reduction of epithelial cell apoptosis, and with Marini et al 21 in Samp/YitFc mice, a murine model with spontaneous ileitis resembling human CD very closely, where the administration of a chimeric rat/mouse anti-TNF-?
Spec (investigated) Regulation (effects) of IFX in epithelial cell associated with crohn's disease, infliximab, ileitis and apoptosis
4) Confidence 0.33 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2452978 Disease Relevance 1.26 Pain Relevance 0.37
Indeed, studies in Crohn's disease patients were disappointing with ETC 11, whereas the efficacy of IFX and ADA have been well documented.
Regulation (efficacy) of IFX associated with infliximab, crohn's disease, adalimumab, disease and etanercept
5) Confidence 0.33 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2452978 Disease Relevance 0.83 Pain Relevance 0.94
and its specific inhibitor infliximab (IFX) on human MFs under controlled in vitro conditions.
Regulation (controlled) of IFX associated with infliximab
6) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875629 Disease Relevance 0.61 Pain Relevance 0.29
Adalimumab was similarly effective for patients with prior IFX or ETN therapy.
Regulation (effective) of IFX associated with infliximab, adalimumab and etanercept
7) Confidence 0.06 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911911 Disease Relevance 0.57 Pain Relevance 0.95

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