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Context Info
Confidence 0.61
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.66
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1) extracellular region (SERPINE1) plasma membrane (SERPINE1)
Anatomy Link Frequency
cartilage 1
SERPINE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 9 100.00 Very High Very High Very High
Arthritis 1 99.16 Very High Very High Very High
dexamethasone 4 96.28 Very High Very High Very High
cINOD 2 95.00 High High
agonist 43 76.20 Quite High
Inflammation 24 18.36 Low Low
ischemia 4 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 149 99.84 Very High Very High Very High
Disease 14 99.84 Very High Very High Very High
Arthritis 1 99.16 Very High Very High Very High
INFLAMMATION 28 94.76 High High
Hematologic Neoplasms 39 91.56 High High
Adhesions 7 90.40 High High
Leukemia 12 89.12 High High
Apoptosis 27 80.96 Quite High
Necrosis 2 75.00 Quite High
Coronary Heart Disease 1 21.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of PAI-1 levels by cytokines and reagents which stimulate cartilage resorption (i.e., TNF alpha, interleukin-1 alpha, retinoic acid) and enhancement by cytokines which counter it (i.e., TGF-beta, bFGF) further implicate plasminogen activator in the mechanism(s) of cartilage degradation in diseases such as arthritis.
Protein_catabolism (degradation) of PAI-1 in cartilage associated with disease, arthritis and cytokine
1) Confidence 0.61 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 8054359 Disease Relevance 0.58 Pain Relevance 0.43
ligands upregulate expression and release of PAI-1 from ECs [193], which would inhibit degradation of tumor-associated fibrin leading to EC migration, proliferation, and angiogenesis [231].
Protein_catabolism (degradation) of PAI-1 associated with cancer
2) Confidence 0.08 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.07 Pain Relevance 0.04

General Comments

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