INT56098

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Context Info
Confidence 0.59
First Reported 1994
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.89
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB3) signal transduction (HLA-DRB3) Golgi apparatus (HLA-DRB3)
endoplasmic reticulum (HLA-DRB3) plasma membrane (HLA-DRB3)
Anatomy Link Frequency
tubule 1
HLA-DRB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 7 99.48 Very High Very High Very High
Chronic pancreatitis 4 99.46 Very High Very High Very High
lidocaine 3 94.64 High High
Mexiletine 1 93.76 High High
rheumatoid arthritis 34 92.08 High High
fibrosis 2 86.56 High High
spinal inflammation 1 85.88 High High
Infliximab 31 76.60 Quite High
Arthritis 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 1 99.60 Very High Very High Very High
INFLAMMATION 7 99.48 Very High Very High Very High
Pancreatitis 4 99.46 Very High Very High Very High
Autoimmune Disease 12 98.12 Very High Very High Very High
Rheumatoid Arthritis 36 92.08 High High
Disease 27 91.52 High High
Iron Overload 6 89.04 High High
Celiac Disease 1 87.20 High High
Fibrosis 2 86.56 High High
Low Back Pain 1 85.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sixty-one patients with confirmed chronic pancreatitis were analysed, 30 of whom expressed HLA-DR 3 and/or DR 4.
Gene_expression (expressed) of HLA-DR 3 associated with chronic pancreatitis
1) Confidence 0.59 Published 1994 Journal Diabetologia Section Abstract Doc Link 8056184 Disease Relevance 0.68 Pain Relevance 0.23
The purpose of this study was to elucidate the molecular mechanism underlying the transport of antiarrhythmic drugs using cells from the second segment of the proximal tubule (S2) cells of mice expressing human-organic cation transporter 3 (S2 human-OCT3).
Gene_expression (expressing) of human-OCT3 in tubule
2) Confidence 0.57 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363950 Disease Relevance 0 Pain Relevance 0.28
Inflammatory islet damage in patients bearing HLA-DR 3 and/or DR 4 haplotypes does not lead to islet autoimmunity.
Gene_expression (bearing) of HLA-DR 3 associated with autoimmune disease and inflammation
3) Confidence 0.51 Published 1994 Journal Diabetologia Section Title Doc Link 8056184 Disease Relevance 0.70 Pain Relevance 0.28
Type I diabetes mellitus is associated with HLA-DR3,4 heterozygotes, and the absence of asparagine at position 57 on the DQ?
Gene_expression (heterozygotes) of HLA-DR3 associated with diabetes mellitus
4) Confidence 0.35 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 1.51 Pain Relevance 0.13
We have found that the group of 8 predictor genes is preferentially selected at each independent round of cross validation demonstrating the strong correlation between gene expression and the type of response; some genes –HLA-DRB3, SH2D1B and GNLY-, are even selected at all rounds.
Gene_expression (selected) of HLA-DRB3
5) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2762038 Disease Relevance 0 Pain Relevance 0.07

General Comments

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