INT5610

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Context Info
Confidence 0.69
First Reported 1981
Last Reported 2010
Negated 6
Speculated 5
Reported most in Abstract
Documents 140
Total Number 145
Disease Relevance 37.26
Pain Relevance 86.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr)
Anatomy Link Frequency
neurons 20
hypothalamus 12
MnPO 7
spinal cord 6
brain 6
Insr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 168 100.00 Very High Very High Very High
Dynorphin 158 100.00 Very High Very High Very High
Somatostatin 156 100.00 Very High Very High Very High
Enkephalin 137 100.00 Very High Very High Very High
substance P 105 100.00 Very High Very High Very High
Calcitonin gene-related peptide 104 100.00 Very High Very High Very High
opioid receptor 60 100.00 Very High Very High Very High
Catecholamine 8 100.00 Very High Very High Very High
vanilloid receptor subtype 1 5 100.00 Very High Very High Very High
narcan 46 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 72 100.00 Very High Very High Very High
Ganglion Cysts 56 100.00 Very High Very High Very High
Insulin Resistance 30 100.00 Very High Very High Very High
Hyperinsulinism 3 100.00 Very High Very High Very High
Convulsion 23 99.82 Very High Very High Very High
Stress 63 99.80 Very High Very High Very High
Cystitis 15 99.76 Very High Very High Very High
Pain 138 99.58 Very High Very High Very High
Coronary Artery Disease 14 99.40 Very High Very High Very High
Hyperalgesia 22 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present results indicate that the induction of Fos-IR neurons in the dorsal horn caused by CCI is biphasic and reaches its maximal level on PO 3d, near the time of hyperalgesia onset.
Positive_regulation (induction) of Fos-IR in neurons associated with hyperalgesia, eae and dorsal horn
1) Confidence 0.69 Published 2001 Journal Brain Res. Section Abstract Doc Link 11578603 Disease Relevance 0.53 Pain Relevance 0.88
The occurrence of long lasting increases in the contents of IR-Met and IR-Oct in the hypothalamus of rats that copulated was detected.
Positive_regulation (increases) of IR-Met in hypothalamus
2) Confidence 0.67 Published 2002 Journal Behav. Brain Res. Section Abstract Doc Link 11844571 Disease Relevance 0.07 Pain Relevance 0.57
The occurrence of long lasting increases in the contents of IR-Met and IR-Oct in the hypothalamus of rats that copulated was detected.
Positive_regulation (increases) of IR-Oct in hypothalamus
3) Confidence 0.67 Published 2002 Journal Behav. Brain Res. Section Abstract Doc Link 11844571 Disease Relevance 0.07 Pain Relevance 0.57
The increase of RT97-IR afferents may be related to the mechanisms for the observed allodynia.


Positive_regulation (increase) of RT97-IR
4) Confidence 0.66 Published 2007 Journal Spine Section Body Doc Link 17515813 Disease Relevance 0 Pain Relevance 0
The present results of a reduction of Fos-IR neurons by morphine pretreatment suggest that the induction of Fos-IR neurons may be due to the noxious stimulation caused by induction of experimental tooth movement.
Positive_regulation (induction) of Fos-IR in neurons associated with morphine
5) Confidence 0.66 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082860 Disease Relevance 0 Pain Relevance 0.35
Pretreatment with morphine (3 and 10 mg/kg, i.p.) significantly reduced the induction of Fos-IR neurons at the superficial layers of the ipsilateral SpVc in a dose-dependent manner, and its effect was antagonized by the subsequent treatment of naloxone (2 mg/kg, i.p.).
Positive_regulation (induction) of Fos-IR in neurons associated with narcan and morphine
6) Confidence 0.66 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082860 Disease Relevance 0.05 Pain Relevance 0.43
RESULTS: Noxious stimulation resulted in a general and strong increase in Fos-IR in the ipsilateral dorsal horn, mainly in Laminae I, II, and V.
Positive_regulation (increase) of Fos-IR in dorsal horn
7) Confidence 0.65 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19843805 Disease Relevance 0 Pain Relevance 0
Thoracic spinal block caused a remarkable increase in the amount of Fos-IR in Lamina V, but had no significant effect on the Fos-IR in Laminae I and II.
Positive_regulation (increase) of Fos-IR in Lamina
8) Confidence 0.65 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19843805 Disease Relevance 0 Pain Relevance 0
In comparison with the respective baseline levels, innocuous stimulation did not induce a significant increase in the numbers of Fos-IR neurons in controls or STZ-rats.
Positive_regulation (increase) of Fos-IR in neurons
9) Confidence 0.60 Published 2007 Journal Diabetes Metab. Res. Rev. Section Body Doc Link 17506118 Disease Relevance 0.07 Pain Relevance 0
Dyn A-IR, but not LE-IR, was also significantly depleted in some forebrain nuclei in all experimental groups as compared with intact controls, whereas Dyn A-IR in the hypothalamic ventromedial nucleus was elevated only in the sham-control rats.
Positive_regulation (elevated) of A-IR in nucleus
10) Confidence 0.57 Published 1985 Journal Am. J. Physiol. Section Abstract Doc Link 2863984 Disease Relevance 0.49 Pain Relevance 0.27
CONCLUSIONS: The increase in Fos-IR in Lamina V may have resulted from the interruption of a pain-modulating descending mechanism from the brain.
Positive_regulation (increase) of Fos-IR in brain
11) Confidence 0.57 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19843805 Disease Relevance 0 Pain Relevance 0
Although obvious increase in IL-1beta-IR could be observed in the lumbar segments of the spinal cord ipsilateral to a hind paw incision, significant upregulation of IL-1beta was not detected in the lumbar segments following thoracic incision.
Positive_regulation (increase) of IR in spinal cord associated with spinal cord
12) Confidence 0.53 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 16733810 Disease Relevance 0.08 Pain Relevance 0.48
IR-LE and IR-OC release was enhanced 4 h later (20:00 h), no changes were detected for IR-HE.
Positive_regulation (enhanced) of IR-LE
13) Confidence 0.50 Published 1998 Journal Neuropeptides Section Abstract Doc Link 10189066 Disease Relevance 0 Pain Relevance 0.55
The present results indicate that the induction of Fos-IR neurons in the dorsal horn caused by CCI is biphasic and reaches its maximal level on PO 3d, near the time of hyperalgesia onset.
Positive_regulation (induction) of Fos-IR in neurons associated with hyperalgesia, eae and dorsal horn
14) Confidence 0.50 Published 2001 Journal Brain Res. Section Abstract Doc Link 11578603 Disease Relevance 0.53 Pain Relevance 0.88
Pretreatment with morphine (3 and 10 mg/kg, i.p.) significantly reduced the induction of Fos-IR neurons at the superficial layers of the ipsilateral SpVc in a dose-dependent manner, and its effect was antagonized by the subsequent treatment of naloxone (2 mg/kg, i.p.).
Positive_regulation (induction) of Fos-IR in neurons associated with narcan and morphine
15) Confidence 0.48 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082860 Disease Relevance 0.05 Pain Relevance 0.43
The present results of a reduction of Fos-IR neurons by morphine pretreatment suggest that the induction of Fos-IR neurons may be due to the noxious stimulation caused by induction of experimental tooth movement.
Positive_regulation (induction) of Fos-IR in neurons associated with morphine
16) Confidence 0.48 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082860 Disease Relevance 0 Pain Relevance 0.35
Chronic administration of the first and second generation antidepressants imipramine, citalopram and rolipram, and of the antidepressant neuroleptics levomepromazine and chlorprothixene elevated the level of ir-beta E in the hypothalamus.
Positive_regulation (elevated) of ir-beta in hypothalamus associated with antidepressant
17) Confidence 0.47 Published 1985 Journal Neuropeptides Section Abstract Doc Link 3858703 Disease Relevance 0.09 Pain Relevance 0.66
In male rats, prenatal morphine exposure significantly increased the density of TH-IR in cells and fibers in the caudal paraventricular nucleus of the hypothalamus (PVN) and locus coeruleus (LC), but had no effects in the lateral hypothalamus (LH).
Positive_regulation (increased) of TH-IR in nucleus associated with locus ceruleus and morphine
18) Confidence 0.45 Published 2000 Journal Brain Res. Bull. Section Abstract Doc Link 10718519 Disease Relevance 0.07 Pain Relevance 0.60
Administrations of morphine (3 and 10 mg/kg, i.p.) drastically reduced the induction of Fos-IR neurons in all subnuclei of both the ipsilateral and contralateral PBN in a dose-dependent manner, and its effect was antagonized by pretreatment with naloxone (2 mg/kg, i.p.).
Positive_regulation (induction) of Fos-IR in neurons associated with narcan and morphine
19) Confidence 0.45 Published 2001 Journal Brain Res. Section Abstract Doc Link 11454327 Disease Relevance 0.07 Pain Relevance 0.29
Twenty-four hours after sexual activity, there was a generalised increase in enkephalin contents that returned to control values at the 48 h measurement in all brain areas, but the hypothalamus, where IR-Met and IR-Oct remained elevated.
Positive_regulation (elevated) of IR-Oct in hypothalamus associated with enkephalin
20) Confidence 0.45 Published 2002 Journal Behav. Brain Res. Section Abstract Doc Link 11844571 Disease Relevance 0.09 Pain Relevance 0.73

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