INT56100

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Context Info
Confidence 0.48
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.07
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ighm)
Anatomy Link Frequency
red blood cells 2
Ighm (Mus musculus)
Pain Link Frequency Relevance Heat
depression 2 100.00 Very High Very High Very High
Enkephalin 7 98.00 Very High Very High Very High
Morphine 16 96.00 Very High Very High Very High
rheumatoid arthritis 50 52.24 Quite High
Arthritis 5 26.96 Quite Low
narcan 1 25.00 Low Low
Osteoarthritis 21 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 2 100.00 Very High Very High Very High
Burns 12 99.76 Very High Very High Very High
Injury 8 99.56 Very High Very High Very High
Bacterial Meningitis 1 86.48 High High
Death 1 77.36 Quite High
General Immunology 1 73.60 Quite High
Rheumatoid Arthritis 50 52.24 Quite High
Crystal Associated Disease 26 50.00 Quite Low
Hyperuricemia 8 50.00 Quite Low
Arthritis 5 26.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PTXF treatment was associated with an increase in IgG production, but a greater depression in IgM synthesis than burn injury alone.
Negative_regulation (depression) of Gene_expression (synthesis) of IgM associated with depression, burns and injury
1) Confidence 0.48 Published 1997 Journal J Burn Care Rehabil Section Abstract Doc Link 9313117 Disease Relevance 1.86 Pain Relevance 0.17
Results show that proliferation was not affected by either peptide, but that IgM, IgG3 and IgG2a production were inhibited in a concentration- and time-dependent manner by MENK.
Negative_regulation (inhibited) of Gene_expression (production) of IgM associated with enkephalin
2) Confidence 0.31 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9058757 Disease Relevance 0 Pain Relevance 0.45
The primary IgM antibody response to the T-dependent antigen, sheep red blood cells, was decreased.
Negative_regulation (decreased) of Gene_expression (response) of IgM in red blood cells
3) Confidence 0.29 Published 1994 Journal Fundam Appl Toxicol Section Abstract Doc Link 8056200 Disease Relevance 0.09 Pain Relevance 1.07
Rituximab significantly reduced immunoglobulin production at the mRNA level, as well as total IgM and IgG content in synovia containing lymphoid aggregates, but not in synovia where lymphoid infiltration was diffuse.
Negative_regulation (reduced) of Gene_expression (production) of IgM
4) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592782 Disease Relevance 0.05 Pain Relevance 0.03
(A similar protocol was used to detect IgM antibodies, but using anti-human ?
Negative_regulation (detect) of Gene_expression (antibodies) of IgM
5) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526556 Disease Relevance 0.07 Pain Relevance 0

General Comments

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