INT56122

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1994
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 7
Total Number 10
Disease Relevance 2.25
Pain Relevance 4.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcc3) ATPase activity (Abcc3) transmembrane transport (Abcc3)
Anatomy Link Frequency
intestine 3
blood 1
hypothalamus 1
CAR 1
striatum 1
Abcc3 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 26 100.00 Very High Very High Very High
Serotonin 5 100.00 Very High Very High Very High
fluoxetine 4 99.84 Very High Very High Very High
Paracetamol 15 99.56 Very High Very High Very High
diclofenac 9 98.98 Very High Very High Very High
opiate 8 98.44 Very High Very High Very High
Opioid 2 97.56 Very High Very High Very High
Bile 4 94.72 High High
Morphine 26 93.40 High High
antidepressant 1 90.88 High High
Disease Link Frequency Relevance Heat
Respiratory Tract Infection 3 97.16 Very High Very High Very High
Toxicity 4 96.24 Very High Very High Very High
Breast Cancer 2 96.08 Very High Very High Very High
Hepatotoxicity 11 86.56 High High
Disorder Of Lipid Metabolism 33 84.36 Quite High
Opiate Addiction 2 69.92 Quite High
Cancer Pain 1 67.44 Quite High
Rheumatoid Arthritis 1 65.80 Quite High
Morphine Dependence 2 65.68 Quite High
Post Operative Pain 1 64.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study aimed to examine the importance of multidrug resistance-associated protein 3 (Mrp3/Abcc3) in the serosal efflux of glucuronide conjugates formed in the intestine using wild-type and Mrp3(-/-) mice.
Spec (examine) Positive_regulation (importance) of multidrug resistance-associated protein 3 in intestine
1) Confidence 0.47 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19889793 Disease Relevance 0 Pain Relevance 0
This study aimed to examine the importance of multidrug resistance-associated protein 3 (Mrp3/Abcc3) in the serosal efflux of glucuronide conjugates formed in the intestine using wild-type and Mrp3(-/-) mice.
Spec (examine) Positive_regulation (importance) of Mrp3 in intestine
2) Confidence 0.47 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19889793 Disease Relevance 0 Pain Relevance 0
This study aimed to examine the importance of multidrug resistance-associated protein 3 (Mrp3/Abcc3) in the serosal efflux of glucuronide conjugates formed in the intestine using wild-type and Mrp3(-/-) mice.
Spec (examine) Positive_regulation (importance) of Abcc3 in intestine
3) Confidence 0.45 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19889793 Disease Relevance 0 Pain Relevance 0
In contrast, multidrug resistance-associated proteins Mrp1, Mrp2, Mrp3, and Mrp4, as well as multidrug resistance proteins Mdr1a and Mdr1b genes, were increased following APAP.
Positive_regulation (increased) of Mrp3 associated with paracetamol
4) Confidence 0.45 Published 2007 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 17934960 Disease Relevance 0.30 Pain Relevance 0.88
We further show that the sinusoidal efflux of diclofenac acyl glucuronide, from liver to blood, is largely dependent on multidrug resistance protein 3 (MRP3/ABCC3).
Positive_regulation (dependent) of multidrug resistance protein 3 in blood associated with diclofenac
5) Confidence 0.43 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20086033 Disease Relevance 0.50 Pain Relevance 0.62
Occupancy of the serotonin transporter by fluoxetine, paroxetine, and sertraline: in vivo studies with [125I]RTI-55.

[125I]RTI-55 was used tracer doses to label serotonin (5-HT) transporters in vivo in the mouse brain.

Positive_regulation (Occupancy) of transporter in brain associated with respiratory tract infection, serotonin and fluoxetine
6) Confidence 0.35 Published 1994 Journal Synapse Section Title Doc Link 8059336 Disease Relevance 0.26 Pain Relevance 0.58
Comparison of their responses to LCA treatment demonstrates that CAR predominantly mediates induction of the cytochrome p450 CYP3A11 and the multidrug resistance-associated protein 3 transporter, whereas PXR is the major regulator of the Na+-dependent organic anion transporter 2.
Positive_regulation (induction) of multidrug resistance-associated protein 3 transporter in CAR
7) Confidence 0.32 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15358766 Disease Relevance 0.25 Pain Relevance 0.19
Both cholesterol efflux and the transcription of efflux-related receptors, namely CD36 and ATP-binding cassette protein A1, were increased by niacin.
Positive_regulation (increased) of ATP-binding cassette protein
8) Confidence 0.22 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605342 Disease Relevance 0.67 Pain Relevance 0
Up-regulation of adenosine transporter-binding sites in striatum and hypothalamus of opiate tolerant mice.
Positive_regulation (Up-regulation) of transporter-binding in striatum associated with adenocard and opiate
9) Confidence 0.16 Published 1997 Journal Brain Res. Section Title Doc Link 9296562 Disease Relevance 0.14 Pain Relevance 1.32
Up-regulation of adenosine transporter-binding sites in striatum and hypothalamus of opiate tolerant mice.
Positive_regulation (Up-regulation) of transporter-binding in hypothalamus associated with adenocard and opiate
10) Confidence 0.05 Published 1997 Journal Brain Res. Section Title Doc Link 9296562 Disease Relevance 0.14 Pain Relevance 1.32

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox