INT56127

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Context Info
Confidence 0.49
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.30
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NGFR) endosome (NGFR) nucleoplasm (NGFR)
cytoplasm (NGFR) signal transducer activity (NGFR) cytosol (NGFR)
Anatomy Link Frequency
neurons 2
nerve 1
sympathetic 1
NGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 3 100.00 Very High Very High Very High
Inflammation 18 96.88 Very High Very High Very High
cINOD 8 96.30 Very High Very High Very High
anesthesia 1 92.12 High High
epidural 1 91.68 High High
backache 10 86.72 High High
addiction 5 72.04 Quite High
Sciatica 4 68.72 Quite High
rheumatoid arthritis 17 55.56 Quite High
metalloproteinase 1 52.08 Quite High
Disease Link Frequency Relevance Heat
Cancer 40 100.00 Very High Very High Very High
Death 38 99.96 Very High Very High Very High
Reprotox - General 1 2 97.28 Very High Very High Very High
INFLAMMATION 17 96.88 Very High Very High Very High
Apoptosis 65 96.64 Very High Very High Very High
Prostate Cancer 39 92.64 High High
Low Back Pain 11 86.72 High High
Congenital Anomalies 3 82.80 Quite High
Toxicity 16 80.24 Quite High
Injury 15 78.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PURPOSE: Previously, we reported in vitro observations suggesting that ibuprofen is an effective non-prescription non-steroidal anti-inflammatory drug (NSAID) to reduce the survival of human prostate cancer cells (Andrews et al. in Cancer Chemother Pharmacol 502:77-284, 2002), and that this observed effectiveness is mediated by an up-regulation of the p75 NTR tumor suppressor (Khwaja et al. in Cancer Res 646:207-6213, 2004).
Positive_regulation (up-regulation) of p75 NTR associated with inflammation, cancer, cinod and reprotox - general 1
1) Confidence 0.49 Published 2008 Journal Cancer Chemother. Pharmacol. Section Abstract Doc Link 17447067 Disease Relevance 0.87 Pain Relevance 0.39
We also evaluated whether, like ibuprofen, an up-regulation of p75 NTR is a molecular mechanism that mediates the anti-growth effectiveness of these drugs.
Positive_regulation (up-regulation) of p75 NTR
2) Confidence 0.49 Published 2008 Journal Cancer Chemother. Pharmacol. Section Abstract Doc Link 17447067 Disease Relevance 0.78 Pain Relevance 0.35
A certain expression of CD271 was maintained but cells positive for both CD271 and CD34 were not longer detected (Table 5).


Positive_regulation (positive) of CD271
3) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.06 Pain Relevance 0.03
First, zinc-exposed neurons show an induction of the neutrophin receptor p75NTR and p75NTR-associated death executor (NADE) [157], a combination that can trigger caspase activation and apoptosis [158].
Positive_regulation (induction) of p75NTR-associated in neurons associated with apoptosis and death
4) Confidence 0.15 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872358 Disease Relevance 1.42 Pain Relevance 0
has been shown to result in the sensitisation of nerve roots and stimulation of nerve growth factor [15,26,27].
Positive_regulation (stimulation) of nerve growth factor in nerve associated with nerve growth factor
5) Confidence 0.14 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206382 Disease Relevance 0.25 Pain Relevance 0.28
First, zinc-exposed neurons show an induction of the neutrophin receptor p75NTR and p75NTR-associated death executor (NADE) [157], a combination that can trigger caspase activation and apoptosis [158].
Positive_regulation (induction) of p75NTR in neurons associated with apoptosis and death
6) Confidence 0.13 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872358 Disease Relevance 1.41 Pain Relevance 0
Although the etiology of autonomic nerve disturbances in these cases remains to be elucidated, a positive immunoreactivity of nerve growth factor receptor (NGFR) implies the possibility of some unknown sympathetic neurovascular disorder involving muscle degeneration.
Positive_regulation (immunoreactivity) of NGFR in sympathetic associated with nerve growth factor
7) Confidence 0.13 Published 1994 Journal Brain Dev. Section Abstract Doc Link 8059932 Disease Relevance 0.22 Pain Relevance 0.19
Our network model included: nuclear hormone and transmembrane growth factor receptor activation; transcriptional activity via the MAPK subsystem [28]–[30] together with outlaw activation of AR via MAPK [15], [18]; PI3K/AKT/TOR mediated translation initiation [31], [32]; the transcriptional and translational regulation of PSA, cyclin D and PAcP expression [14], [20]; and the regulation of Her2 activity by PAcP [26] (Fig. 1).
Positive_regulation (activation) of transmembrane growth factor receptor
8) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.29 Pain Relevance 0.04

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