INT56130

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Context Info
Confidence 0.78
First Reported 1994
Last Reported 2011
Negated 7
Speculated 9
Reported most in Abstract
Documents 259
Total Number 269
Disease Relevance 62.70
Pain Relevance 97.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (MC1R) plasma membrane (MC1R) signal transducer activity (MC1R)
Anatomy Link Frequency
melanocytes 50
skin 34
pigmentation 17
keratinocytes 14
hair 11
MC1R (Homo sapiens)
MC1R - V92M (1) MC1R - R151C (1)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 2522 100.00 Very High Very High Very High
antagonist 42 100.00 Very High Very High Very High
Inflammatory response 13 99.92 Very High Very High Very High
Central grey 2 99.48 Very High Very High Very High
ischemia 4 99.40 Very High Very High Very High
Potency 21 98.82 Very High Very High Very High
Enkephalin 3 98.76 Very High Very High Very High
agonist 141 98.52 Very High Very High Very High
Inflammation 120 97.32 Very High Very High Very High
adenocard 17 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Skin Cancer 314 100.00 Very High Very High Very High
Keratosis 1 100.00 Very High Very High Very High
Melanoma 1347 99.98 Very High Very High Very High
Amelanotic Melanoma 1 99.84 Very High Very High Very High
Nevus 259 99.80 Very High Very High Very High
Obesity 152 99.60 Very High Very High Very High
Acne 58 99.60 Very High Very High Very High
INFLAMMATION 147 99.52 Very High Very High Very High
Urological Neuroanatomy 4 99.48 Very High Very High Very High
Cv Unclassified Under Development 4 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The MC1R was found to be present in Leydig's cells in testis, in lutein cells in the corpus luteum and in the nucleus of the trophoblastic cells of the placenta.
Gene_expression (present) of MC1R in nucleus associated with melanocortin 1 receptor
1) Confidence 0.78 Published 1997 Journal Horm. Res. Section Abstract Doc Link 9362391 Disease Relevance 0 Pain Relevance 0.53
We describe the immunohistochemical detection of the melanocortin 1 receptor (MC1R) protein in human gonadal tissues using a specific monoclonal antibody.
Gene_expression (detection) of melanocortin 1 receptor in gonadal associated with melanocortin 1 receptor
2) Confidence 0.78 Published 1997 Journal Horm. Res. Section Abstract Doc Link 9362391 Disease Relevance 0 Pain Relevance 0.52
We describe the immunohistochemical detection of the melanocortin 1 receptor (MC1R) protein in human gonadal tissues using a specific monoclonal antibody.
Gene_expression (detection) of MC1R in gonadal associated with melanocortin 1 receptor
3) Confidence 0.78 Published 1997 Journal Horm. Res. Section Abstract Doc Link 9362391 Disease Relevance 0 Pain Relevance 0.52
The melanocortin 1 receptor, a Gs protein-coupled receptor expressed in epidermal melanocytes, is a major determinant of skin pigmentation and phototype and an important contributor to melanoma risk.
Gene_expression (expressed) of melanocortin 1 receptor in pigmentation associated with melanocortin 1 receptor and skin cancer
4) Confidence 0.78 Published 2009 Journal Hum. Mutat. Section Abstract Doc Link 19338054 Disease Relevance 0.24 Pain Relevance 0.17
We found that total melanin and eumelanin contents (MC and EC) correlated inversely with the extent of UVR-induced growth arrest, apoptosis and induction of cyclobutane pyrimidine dimers (CPD), but not with hydrogen peroxide release in melanocytes expressing functional MC1R.
Gene_expression (expressing) of MC1R in melanocytes associated with melanocortin 1 receptor and apoptosis
5) Confidence 0.78 Published 2006 Journal Pigment Cell Res. Section Abstract Doc Link 16827749 Disease Relevance 0.72 Pain Relevance 0.58
Melanocortin-1 receptor B is expressed in testis, fetal heart and melanomas.
Gene_expression (expressed) of Melanocortin-1 receptor B in heart associated with melanocortin 1 receptor and melanoma
6) Confidence 0.78 Published 1999 Journal FEBS Lett. Section Abstract Doc Link 10371153 Disease Relevance 0.10 Pain Relevance 0.72
Both saturation and competition analysis, using alpha-, beta-, and gamma 1-MSH on the tagged MC1R expressed in the insect cells, gave binding constants and potency orders that were undistinguishable from those obtained on MC1R expressed in COS cells.
Gene_expression (expressed) of MC1R associated with melanocortin 1 receptor and potency
7) Confidence 0.78 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8630043 Disease Relevance 0 Pain Relevance 0.54
We expressed epitope-tagged human melanocortin 1 receptor (MC1R) in insect cells using two different recombinant baculovirus constructs; one of which encoded MC1R with an N-terminal Flag epitope and a C-terminal polyHis tag, while the other encoded the MC1R with a C-terminal Myc tag.
Gene_expression (expressed) of MC1R associated with melanocortin 1 receptor
8) Confidence 0.78 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8630043 Disease Relevance 0 Pain Relevance 0.44
Both saturation and competition analysis, using alpha-, beta-, and gamma 1-MSH on the tagged MC1R expressed in the insect cells, gave binding constants and potency orders that were undistinguishable from those obtained on MC1R expressed in COS cells.
Gene_expression (expressed) of MC1R associated with melanocortin 1 receptor and potency
9) Confidence 0.78 Published 1996 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8630043 Disease Relevance 0 Pain Relevance 0.56
Activation by melanocortins of the melanocortin 1 receptor (MC1R), expressed in epidermal melanocytes, stimulates melanogenesis.
Gene_expression (expressed) of melanocortin 1 receptor in melanocytes associated with melanocortin 1 receptor
10) Confidence 0.78 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11707265 Disease Relevance 0.09 Pain Relevance 0.37
Activation by melanocortins of the melanocortin 1 receptor (MC1R), expressed in epidermal melanocytes, stimulates melanogenesis.
Gene_expression (expressed) of MC1R in melanocytes associated with melanocortin 1 receptor
11) Confidence 0.78 Published 2001 Journal FEBS Lett. Section Abstract Doc Link 11707265 Disease Relevance 0.09 Pain Relevance 0.37
The melanocortin 1 receptor (MC1R) is a dimeric G protein-coupled receptor expressed in melanocytes, where it regulates the amount and type of melanins produced and determines the tanning response to ultraviolet radiation.
Gene_expression (expressed) of MC1R in melanocytes associated with melanocortin 1 receptor
12) Confidence 0.78 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18222116 Disease Relevance 0 Pain Relevance 0.41
The melanocortin 1 receptor (MC1R) is a dimeric G protein-coupled receptor expressed in melanocytes, where it regulates the amount and type of melanins produced and determines the tanning response to ultraviolet radiation.
Gene_expression (expressed) of melanocortin 1 receptor in melanocytes associated with melanocortin 1 receptor
13) Confidence 0.78 Published 2008 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 18222116 Disease Relevance 0 Pain Relevance 0.41
Expression of melanocortin-1 receptor in normal, malformed and neoplastic skin glands and hair follicles.
Gene_expression (Expression) of melanocortin-1 receptor in skin glands associated with melanocortin 1 receptor
14) Confidence 0.78 Published 2002 Journal Exp. Dermatol. Section Title Doc Link 11952827 Disease Relevance 0.47 Pain Relevance 0.19
MC-1R expression was widely preserved in various adnexal malformations and neoplasms as compared with normal skin and did not show major differences with regard to maturation of the neoplasms.
Gene_expression (expression) of MC-1R in skin associated with cancer
15) Confidence 0.78 Published 2002 Journal Exp. Dermatol. Section Abstract Doc Link 11952827 Disease Relevance 0.65 Pain Relevance 0.15
Reduced expression of the melanocortin-1 receptor in human liver during brain death.
Gene_expression (expression) of melanocortin-1 receptor in liver associated with brain death and melanocortin 1 receptor
16) Confidence 0.78 Published 2006 Journal Neuroimmunomodulation Section Title Doc Link 16864968 Disease Relevance 0.64 Pain Relevance 0.36
More than 120 genes have been identified and shown to regulate pigmentation, one of the key genes being melanocortin 1 receptor (MC1R) that encodes the melanocortin 1 receptor (MC1R), a seven-transmembrane G protein-coupled receptor expressed on the surface of melanocytes.
Gene_expression (expressed) of melanocortin 1 receptor in pigmentation associated with melanocortin 1 receptor
17) Confidence 0.78 Published 2005 Journal Mutat. Res. Section Abstract Doc Link 15748644 Disease Relevance 0.09 Pain Relevance 0.77
More than 120 genes have been identified and shown to regulate pigmentation, one of the key genes being melanocortin 1 receptor (MC1R) that encodes the melanocortin 1 receptor (MC1R), a seven-transmembrane G protein-coupled receptor expressed on the surface of melanocytes.
Gene_expression (expressed) of MC1R in pigmentation associated with melanocortin 1 receptor
18) Confidence 0.78 Published 2005 Journal Mutat. Res. Section Abstract Doc Link 15748644 Disease Relevance 0.09 Pain Relevance 0.77
Epidermal melanocytes and keratinocytes respond to UVR by increasing their expression of alphaMSH and ACTH, which up-regulate the expression of MC1R, and consequently enhance the response of melanocytes to melanocortins.
Gene_expression (expression) of MC1R in melanocytes associated with melanocortin 1 receptor
19) Confidence 0.78 Published 2005 Journal Mutat. Res. Section Abstract Doc Link 15748644 Disease Relevance 0.38 Pain Relevance 0.85
Several observations such as induction of constitutive pigmentation in amelanotic mouse melanoma cells following expression of MC1R indicate that the receptor might display agonist-independent activity.
Gene_expression (expression) of MC1R in pigmentation associated with melanocortin 1 receptor, agonist and skin cancer
20) Confidence 0.78 Published 2004 Journal Pigment Cell Res. Section Abstract Doc Link 15250941 Disease Relevance 0.35 Pain Relevance 1.11

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