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Context Info
Confidence 0.71
First Reported 1993
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.72
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell-cell signaling (CALCA, POMC) cytoplasm (CALCA, POMC) extracellular space (CALCA, POMC)
extracellular region (CALCA, POMC) small molecule metabolic process (POMC) aging (CALCA)
Anatomy Link Frequency
plasma 1
pituitary 1
CALCA (Homo sapiens)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
analgesia 2 99.66 Very High Very High Very High
Morphine 1 99.30 Very High Very High Very High
opiate 1 97.60 Very High Very High Very High
Opioid 1 96.84 Very High Very High Very High
Analgesic 9 96.36 Very High Very High Very High
monoamine 1 95.76 Very High Very High Very High
Neurotransmitter 1 95.20 Very High Very High Very High
Pain 7 93.24 High High
Parenteral administration 1 83.08 Quite High
Central nervous system 1 72.48 Quite High
Disease Link Frequency Relevance Heat
Pain 5 93.24 High High
Hypercalcemia 1 86.00 High High
Osteoporosis 2 76.48 Quite High
Nociception 1 74.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several studies in animals and in humans demonstrate that calcitonin increases plasma beta-endorphin levels, acting at the hypothalamic and/or at the pituitary level, either directly or indirectly, through monoaminergic neurotransmitters.
calcitonin Positive_regulation (increases) of beta-endorphin in pituitary associated with neurotransmitter and monoamine
1) Confidence 0.71 Published 1993 Journal Biomed. Pharmacother. Section Abstract Doc Link 8061253 Disease Relevance 0.18 Pain Relevance 0.45
In humans, similarities between calcitonin and morphine-induced analgesia, and reports of calcitonin-induced elevation of plasma beta-endorphin levels, suggest the possible involvement of the endogenous opiate system in mediating the analgesic action of calcitonin.
calcitonin Positive_regulation (elevation) of beta-endorphin in plasma associated with analgesic, opiate, analgesia and morphine
2) Confidence 0.18 Published 2002 Journal Bone Section Abstract Doc Link 12008161 Disease Relevance 0.55 Pain Relevance 1.23

General Comments

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