INT56148

Context Info Confidence 0.78 First Reported 1994 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 5 Total Number 7 Disease Relevance 1.87 Pain Relevance 0.93

endosome (PMEL) extracellular region (PMEL) Golgi apparatus (PMEL) endoplasmic reticulum (PMEL) plasma membrane (PMEL)

Anatomy Link Frequency T cells 2 blood 1 lymphocytes 1 PMEL (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 8 96.80 Opioid 5 91.44 Inflammation 8 75.20 cytokine 16 74.16 abdominal pain 1 71.84 alcohol 1 51.52 cva 32 50.00 corticosteroid 3 5.00 cINOD 3 5.00 tolerance 3 5.00

Disease Link Frequency Relevance Heat Hemorrhage 60 98.32 Stupor 1 95.80 Influenza Virus Infection 6 89.96 Cancer 134 84.76 Pancreatitis 10 84.56 Alagille Syndrome 69 83.60 Stress 1 78.24 INFLAMMATION 8 75.20 Abdominal Pain 1 71.84 Congenital Anomalies 3 64.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We found a significant enhancement of interferon-gamma (IFN-gamma) and soluble interleukin-2 receptor (sIL-2R) release in lipopolysaccharide (LPS)-stimulated whole blood cultures after induction of anesthesia.

Localization (release) of sIL in blood associated with anesthesia

1) Confidence 0.78 Published 2001 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 11710990 Disease Relevance 0.25 Pain Relevance 0.74

When activated, lymphocytes secrete glycoproteins related to particular surface proteins, including soluble forms of the interleukin-2 receptor (sIL-2R) and of the surface proteins CD4 (sCD4) and CD8 (sCD8).

Localization (secrete) of sIL in lymphocytes

2) Confidence 0.73 Published 1994 Journal Digestion Section Abstract Doc Link 8063032 Disease Relevance 0.55 Pain Relevance 0.10

secreting CD8+ clones specific for gp100 and Melan A/MART-1 even before vaccination, and this high frequency did not change (gp100) or slightly decreased (Melan A/MART-1) after vaccination.

Localization (secreting) of gp100

3) Confidence 0.30 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.20 Pain Relevance 0

For gp100, frequencies of 70 × 10-5 and 35 × 10-5 CD8+ T cells secreting IFN-?

Localization (secreting) of gp100 in T cells

4) Confidence 0.30 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.22 Pain Relevance 0

i) For five patients enough PBMC were obtained before and 14 days after the fourth vaccination to analyze the presence of gp100 and Melan A/MART-1 specific CD8+T cells by tetramer staining.

Spec (analyze) Localization (presence) of gp100 in T cells

5) Confidence 0.28 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.44 Pain Relevance 0

To avoid this, Ethics Committees in certain countries (Austria, Denmark and Germany) specified that consent must be obtained after surgery, in order to prove that surgeons' were not influenced in their decision to use TachoSil.

Localization (use) of TachoSil

6) Confidence 0.05 Published 2009 Journal Patient Saf Surg Section Body Doc Link PMC2711964 Disease Relevance 0 Pain Relevance 0

This prospective, non-interventional European surveillance study, conducted in a real-world clinical setting, suggests that patients undergoing surgery who receive TachoSil are not at increased risk of TEEs, major bleeding or immunological events.

Localization (receive) of TachoSil associated with hemorrhage

7) Confidence 0.05 Published 2009 Journal Patient Saf Surg Section Body Doc Link PMC2711964 Disease Relevance 0.22 Pain Relevance 0.09

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