INT56149

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Context Info
Confidence 0.74
First Reported 1994
Last Reported 2010
Negated 0
Speculated 5
Reported most in Body
Documents 56
Total Number 62
Disease Relevance 30.41
Pain Relevance 5.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD8A) plasma membrane (CD8A)
Anatomy Link Frequency
T cells 34
lymphocytes 6
lung 3
monocytes 1
NK cells 1
CD8A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 268 99.98 Very High Very High Very High
spinal inflammation 98 99.92 Very High Very High Very High
psoriasis 50 99.14 Very High Very High Very High
Inflammation 399 98.96 Very High Very High Very High
Catecholamine 1 98.82 Very High Very High Very High
agonist 22 96.68 Very High Very High Very High
rheumatoid arthritis 154 95.20 Very High Very High Very High
abdominal pain 6 92.72 High High
Arthritis 79 89.88 High High
lidocaine 8 89.76 High High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1212 100.00 Very High Very High Very High
Low Back Pain 111 99.92 Very High Very High Very High
Leishmaniasis 50 99.84 Very High Very High Very High
Infection 453 99.76 Very High Very High Very High
Diffuse Cutaneous Leishmaniasis 74 99.52 Very High Very High Very High
Psoriasis 61 99.14 Very High Very High Very High
Necrosis 36 99.12 Very High Very High Very High
Leukocytosis 4 99.12 Very High Very High Very High
Mycobacterial Infection 123 99.04 Very High Very High Very High
INFLAMMATION 422 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both types of stress evoke - mainly by release of catecholamines - leukocytosis resulting from a release of natural killer cells (NK-cells), of CD8+ T-cells, of monocytes and of neutrophils.
Localization (release) of CD8 in monocytes associated with catecholamine and leukocytosis
1) Confidence 0.74 Published 2001 Journal Eur J Anaesthesiol Section Abstract Doc Link 11473556 Disease Relevance 0.73 Pain Relevance 0.20
Although still not completely understood, emerging data indicate that the generation of CD4(+) and CD8(+) T cells are important for the clearance of HCV.
Localization (generation) of CD8 in T cells associated with hepatitis c virus infection
2) Confidence 0.74 Published 2009 Journal Human vaccines Section Abstract Doc Link 19246990 Disease Relevance 0.90 Pain Relevance 0
CD8+CD28- T cells have been reported to be effector cells, producing perforin, granzyme B, tumour necrosis factor-?
Localization (reported) of CD8 in T cells associated with necrosis and cancer
3) Confidence 0.71 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 1.29 Pain Relevance 0.42
Cells were then stained for their surface antigens CD28 and CD8 and, after permeabilization, with FITC-conjugated anti-perforin, anti-IFN-?
Localization (permeabilization) of CD8
4) Confidence 0.71 Published 2002 Journal Arthritis Res Section Body Doc Link PMC64855 Disease Relevance 0.35 Pain Relevance 0.18
The uninfected CD8-depleted cohort was chosen to detect the effect of minocycline on SIV infection and not on CD8 depletion.
Localization (depletion) of CD8 associated with infection
5) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.56 Pain Relevance 0
METHODS: Interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) secreted by CD3+ CD8(-)T cells were detected by flow cytometry in 35 patients with CAP/CPPS and 12 healthy volunteers, and significance of Th1/Th2 cells ratio in the etiology of CAP/CPPS was analyzed.
Spec (analyzed) Localization (secreted) of CD8 in T cells
6) Confidence 0.68 Published 2006 Journal Zhonghua Nan Ke Xue Section Body Doc Link 16683566 Disease Relevance 0 Pain Relevance 0
In our experimental conditions, expansion of CD8+ T-cells specific for Tat, Env, and Gag occurred to a comparable extent in most tissues and was highest in the blood of animal 819 (Fig. 5B).
Localization (specific) of CD8 in T-cells
7) Confidence 0.64 Published 2001 Journal BMC Infect Dis Section Body Doc Link PMC37356 Disease Relevance 0.08 Pain Relevance 0
-secreting CD8+ T-cell responses.
Localization (secreting) of CD8 in T-cell
8) Confidence 0.64 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1942115 Disease Relevance 0.23 Pain Relevance 0
In the present work, both CD8 (against short HIV peptides) and CD4 (against TT830-843) response were investigated.


Localization (response) of CD8 associated with acquired immune deficiency syndrome or hiv infection
9) Confidence 0.64 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1942115 Disease Relevance 0.37 Pain Relevance 0.08
secretion by their CD8+ T cells generated against one, two or more peptides, for 8, 3 and 2 of them, respectively.
Localization (secretion) of CD8 in T cells
10) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1942115 Disease Relevance 0.70 Pain Relevance 0.07
Cumulative percentages (95% CI) of CD8+ T cells secreting IFN?
Localization (secreting) of CD8 in T cells
11) Confidence 0.60 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1942115 Disease Relevance 0.71 Pain Relevance 0.07
To examine if there are differences in the cytokine secretion of between CD8 of LCL and DCL patients when they are stimulated with autologous MOi, a 24-h in vitro assay was performed after which lymphocytes were labeled for intracellular IFN?.
Localization (secretion) of CD8 in lymphocytes associated with leishmaniasis, diffuse cutaneous leishmaniasis and cytokine
12) Confidence 0.54 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 1.56 Pain Relevance 0.05
Selective amplification of CD8 T cell responses after TC compared with IM vaccination in healthy individuals
Localization (amplification) of CD8 in T cell
13) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877091 Disease Relevance 0.58 Pain Relevance 0.03
In addition, effector CD4 and CD8 cells both provide cellular immune responses and can secrete multiple cytokines that reflect the quality of the effector-cell compartment of the immune responses.
Localization (secrete) of CD8 associated with cytokine
14) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877091 Disease Relevance 0.70 Pain Relevance 0.05
When activated, lymphocytes secrete glycoproteins related to particular surface proteins, including soluble forms of the interleukin-2 receptor (sIL-2R) and of the surface proteins CD4 (sCD4) and CD8 (sCD8).
Localization (secrete) of CD8 in lymphocytes
15) Confidence 0.51 Published 1994 Journal Digestion Section Abstract Doc Link 8063032 Disease Relevance 0.63 Pain Relevance 0.10
Many accessory molecules involved in the so-called immunologic synapse, have been targeted by biologic therapies (alefacept and efalizumab) which showed a significant efficacy in psoriasis by interfering with the effector CD4+ and CD8+ T lymphocyte activation and secretion of the cytokines (eg, IFN-?
Localization (secretion) of CD8 in T lymphocyte associated with psoriasis and cytokine
16) Confidence 0.45 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721342 Disease Relevance 0.93 Pain Relevance 0.42
Indeed, 4 of the 6 subjects tested had a statistically significant increase in repertoire diversity by 1 wk after the end of treatment (day 21) compared with baseline in CD4+, CD8+, or both T cell populations (Fig. 4).
Localization (baseline) of CD8 in T cell
17) Confidence 0.44 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0 Pain Relevance 0
By ICS analysis, both CD4+ and CD8+ T cell responses were detectable (representative high and low positive samples shown in Figure 4).
Localization (responses) of CD8 in T cell
18) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965084 Disease Relevance 0.33 Pain Relevance 0.04
Antigenic stimulation leads to massive clonal expansion of naïve CD8 T cells and to the acquisition of effector functions, including IFN-?
Localization (expansion) of CD8 in T cells
19) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817732 Disease Relevance 0.38 Pain Relevance 0
Cohort 5 animal groups underwent thymectomy or CD8 depletion or both; the profound CD8 depletion in these animals is depicted in Figure 6.
Localization (depletion) of CD8
20) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2996299 Disease Relevance 0.67 Pain Relevance 0.04

General Comments

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