INT56150

Context Info Confidence 0.45 First Reported 1994 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 7 Total Number 7 Disease Relevance 2.74 Pain Relevance 2.68

signal transduction (IL2RG) plasma membrane (IL2RG)

Anatomy Link Frequency lymphocytes 2 blood 1 HGF 1 T cells 1 IL2RG (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 62 99.12 Inflammation 17 98.90 anesthesia 16 97.16 chemokine 34 96.48 Opioid 2 91.48 bradykinin 66 90.24 agonist 10 72.48 abdominal pain 2 71.44 Kinase C 13 68.52 Inflammatory response 6 65.92

Disease Link Frequency Relevance Heat Infection 50 99.08 INFLAMMATION 23 98.90 Stupor 2 97.08 Stress 2 95.36 Pancreatitis 20 84.16 Fever 34 73.96 Arthralgia 20 73.76 Abdominal Pain 2 71.44 Congenital Anomalies 2 64.16 Rheumatoid Arthritis 6 63.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We found a significant enhancement of interferon-gamma (IFN-gamma) and soluble interleukin-2 receptor (sIL-2R) release in lipopolysaccharide (LPS)-stimulated whole blood cultures after induction of anesthesia.

Localization (release) of soluble interleukin-2 receptor in blood associated with anesthesia

1) Confidence 0.45 Published 2001 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 11710990 Disease Relevance 0.25 Pain Relevance 0.75

Upregulation of IFN-gamma and soluble interleukin-2 receptor release and altered serum cortisol and prolactin concentration during general anesthesia.

Localization (release) of soluble interleukin-2 receptor associated with anesthesia

2) Confidence 0.45 Published 2001 Journal J. Interferon Cytokine Res. Section Title Doc Link 11710990 Disease Relevance 0.23 Pain Relevance 0.72

When activated, lymphocytes secrete glycoproteins related to particular surface proteins, including soluble forms of the interleukin-2 receptor (sIL-2R) and of the surface proteins CD4 (sCD4) and CD8 (sCD8).

Localization (secrete) of interleukin-2 receptor in lymphocytes

3) Confidence 0.02 Published 1994 Journal Digestion Section Abstract Doc Link 8063032 Disease Relevance 0.54 Pain Relevance 0.10

Detection of soluble IL-2R in the plasma suggests T cell activation since this molecule is secreted by activated T cells [38].

Localization (secreted) of IL-2R in T cells

4) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 0.94 Pain Relevance 0.33

When activated, lymphocytes secrete glycoproteins related to particular surface proteins, including soluble forms of the interleukin-2 receptor (sIL-2R) and of the surface proteins CD4 (sCD4) and CD8 (sCD8).

Localization (forms) of interleukin-2 receptor in lymphocytes

5) Confidence 0.02 Published 1994 Journal Digestion Section Abstract Doc Link 8063032 Disease Relevance 0.54 Pain Relevance 0.10

PI3K has been found to mediate phosphorylation and translocation of phospholipase C-gamma and resultant IP3 production in response to activation of P2Y purinergic receptors - this could be one mechanism by which PI3 kinase inhibitors inhibit both the initial response to ATP and the resensitization of P2Y purinergic receptors [38].

Localization (translocation) of C-gamma

6) Confidence 0.01 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0 Pain Relevance 0.39

The following groups of cytokines were: inflammatory (GM-CSF, IL-1beta, IL-1RA, IL-6, IL-8, TNF-alpha); Th1/Th2 (IFN-gamma, IL-2, IL-2R, IL-4, IL-5, IL-10); Cytokine II (IFN-alpha, IL-7, IL-12p40/p70, IL-13, IL-15, IL-17); Chemokines (Eotaxin, IP-10, MCP-1, MIG, MIP-1alpha, MIP-1beta, RANTES); and Growth Factors (EGF, HGF, FGF-basic, G-CSF, VEGF).

Localization (/) of IL-2R in HGF associated with chemokine, inflammation and cytokine

7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 0.23 Pain Relevance 0.29

General Comments

This test has worked.