INT56150

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Context Info
Confidence 0.45
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.74
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL2RG) plasma membrane (IL2RG)
Anatomy Link Frequency
lymphocytes 2
blood 1
HGF 1
T cells 1
IL2RG (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 62 99.12 Very High Very High Very High
Inflammation 17 98.90 Very High Very High Very High
anesthesia 16 97.16 Very High Very High Very High
chemokine 34 96.48 Very High Very High Very High
Opioid 2 91.48 High High
bradykinin 66 90.24 High High
agonist 10 72.48 Quite High
abdominal pain 2 71.44 Quite High
Kinase C 13 68.52 Quite High
Inflammatory response 6 65.92 Quite High
Disease Link Frequency Relevance Heat
Infection 50 99.08 Very High Very High Very High
INFLAMMATION 23 98.90 Very High Very High Very High
Stupor 2 97.08 Very High Very High Very High
Stress 2 95.36 Very High Very High Very High
Pancreatitis 20 84.16 Quite High
Fever 34 73.96 Quite High
Arthralgia 20 73.76 Quite High
Abdominal Pain 2 71.44 Quite High
Congenital Anomalies 2 64.16 Quite High
Rheumatoid Arthritis 6 63.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found a significant enhancement of interferon-gamma (IFN-gamma) and soluble interleukin-2 receptor (sIL-2R) release in lipopolysaccharide (LPS)-stimulated whole blood cultures after induction of anesthesia.
Localization (release) of soluble interleukin-2 receptor in blood associated with anesthesia
1) Confidence 0.45 Published 2001 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 11710990 Disease Relevance 0.25 Pain Relevance 0.75
Upregulation of IFN-gamma and soluble interleukin-2 receptor release and altered serum cortisol and prolactin concentration during general anesthesia.
Localization (release) of soluble interleukin-2 receptor associated with anesthesia
2) Confidence 0.45 Published 2001 Journal J. Interferon Cytokine Res. Section Title Doc Link 11710990 Disease Relevance 0.23 Pain Relevance 0.72
When activated, lymphocytes secrete glycoproteins related to particular surface proteins, including soluble forms of the interleukin-2 receptor (sIL-2R) and of the surface proteins CD4 (sCD4) and CD8 (sCD8).
Localization (secrete) of interleukin-2 receptor in lymphocytes
3) Confidence 0.02 Published 1994 Journal Digestion Section Abstract Doc Link 8063032 Disease Relevance 0.54 Pain Relevance 0.10
Detection of soluble IL-2R in the plasma suggests T cell activation since this molecule is secreted by activated T cells [38].
Localization (secreted) of IL-2R in T cells
4) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 0.94 Pain Relevance 0.33
When activated, lymphocytes secrete glycoproteins related to particular surface proteins, including soluble forms of the interleukin-2 receptor (sIL-2R) and of the surface proteins CD4 (sCD4) and CD8 (sCD8).
Localization (forms) of interleukin-2 receptor in lymphocytes
5) Confidence 0.02 Published 1994 Journal Digestion Section Abstract Doc Link 8063032 Disease Relevance 0.54 Pain Relevance 0.10
PI3K has been found to mediate phosphorylation and translocation of phospholipase C-gamma and resultant IP3 production in response to activation of P2Y purinergic receptors - this could be one mechanism by which PI3 kinase inhibitors inhibit both the initial response to ATP and the resensitization of P2Y purinergic receptors [38].
Localization (translocation) of C-gamma
6) Confidence 0.01 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0 Pain Relevance 0.39
The following groups of cytokines were: inflammatory (GM-CSF, IL-1beta, IL-1RA, IL-6, IL-8, TNF-alpha); Th1/Th2 (IFN-gamma, IL-2, IL-2R, IL-4, IL-5, IL-10); Cytokine II (IFN-alpha, IL-7, IL-12p40/p70, IL-13, IL-15, IL-17); Chemokines (Eotaxin, IP-10, MCP-1, MIG, MIP-1alpha, MIP-1beta, RANTES); and Growth Factors (EGF, HGF, FGF-basic, G-CSF, VEGF).
Localization (/) of IL-2R in HGF associated with chemokine, inflammation and cytokine
7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 0.23 Pain Relevance 0.29

General Comments

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