INT56151

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Context Info
Confidence 0.34
First Reported 1994
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 9.74
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD8A) plasma membrane (CD8A)
Anatomy Link Frequency
T cell 12
lymphocytes 2
skin 2
CD8A (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 25 99.28 Very High Very High Very High
cytokine 138 96.04 Very High Very High Very High
Inflammation 113 94.64 High High
Central nervous system 22 78.84 Quite High
alcohol 1 67.32 Quite High
abdominal pain 1 57.44 Quite High
Biofeedback 3 48.84 Quite Low
Inflammatory response 8 9.68 Low Low
imagery 27 5.00 Very Low Very Low Very Low
Pain 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 193 99.96 Very High Very High Very High
Diffuse Cutaneous Leishmaniasis 222 99.76 Very High Very High Very High
Disease 148 99.74 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 136 99.32 Very High Very High Very High
Anxiety Disorder 18 98.86 Very High Very High Very High
Pancreatitis 12 98.78 Very High Very High Very High
Coronary Artery Disease 2 95.84 Very High Very High Very High
Leishmaniasis 150 95.60 Very High Very High Very High
Hyperplasia 3 94.88 High High
INFLAMMATION 129 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum sIL-2R concentrations were significantly higher in patients with severe pancreatitis than in those with the mild form of the disease, whereas no differences in serum concentrations of sCD8 and sCD4 were found between patients with mild pancreatitis and those with severe disease.
Neg (no) Positive_regulation (differences) of Positive_regulation (concentrations) of sCD8 associated with pancreatitis and disease
1) Confidence 0.34 Published 1994 Journal Digestion Section Abstract Doc Link 8063032 Disease Relevance 1.28 Pain Relevance 0.09
We show that stimulation with TLR2-specific agonists Pam3CyS or with Leishmania LPG can restore the effector functions of CD8 from DCL patients, including IFN?
Positive_regulation (restore) of Positive_regulation (functions) of CD8 associated with agonist and diffuse cutaneous leishmaniasis
2) Confidence 0.34 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.75 Pain Relevance 0.17
Prior to the cytotoxic experiments, the optimal CD8: MOi ratio had been established as 10?
Positive_regulation (established) of Positive_regulation (optimal) of CD8
3) Confidence 0.34 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 1.00 Pain Relevance 0
Interestingly, the leishmanicidal treatment of the DCL patients not only reduced the parasite load but also led to an increase in CD8 during the healing process of the skin lesions of these DCL patients [11].
Positive_regulation (led) of Positive_regulation (increase) of CD8 in skin associated with diffuse cutaneous leishmaniasis
4) Confidence 0.31 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 1.07 Pain Relevance 0.03
CD4+ and CD8+ T cell activation as measured by CD69 expression
Positive_regulation (by) of Positive_regulation (activation) of CD8 in T cell
5) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488375 Disease Relevance 0.07 Pain Relevance 0
CD4+ and CD8+ T cell activation as measured by CD69 expression
Positive_regulation (measured) of Positive_regulation (activation) of CD8 in T cell
6) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2488375 Disease Relevance 0.07 Pain Relevance 0
In vitro, DCs incubated with HIV gag24 coupled to anti-DEC205 mAb induced efficient activation of gag-specific CD8+ and CD4+ T cells [13] (R Steinman).
Positive_regulation (induced) of Positive_regulation (activation) of CD8 in T cells associated with acquired immune deficiency syndrome or hiv infection
7) Confidence 0.23 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.38 Pain Relevance 0
In our preliminary study, both aromatherapy massage and control massage decreased state anxiety significantly, and only aromatherapy massage (P < 0.05) increased PBLs, possibly due to an increase in CD8+ and CD16+ lymphocytes.
Positive_regulation (increased) of Positive_regulation (increase) of CD8 in lymphocytes associated with anxiety disorder
8) Confidence 0.21 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1142199 Disease Relevance 0.42 Pain Relevance 0
However, the circulating CD8+ T cell concentrations were increased significantly when IL-2 was coadministered with vaccine (group D) (p < 0.002) (Figure 4A).
Positive_regulation (increased) of Positive_regulation (circulating) of CD8 in T cell
9) Confidence 0.16 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1783674 Disease Relevance 0.05 Pain Relevance 0
However, recent reports suggest that changes occurring in immunosenescence including the accumulation of anergic CD8+ CD28?
Positive_regulation (immunosenescence) of Positive_regulation (accumulation) of CD8
10) Confidence 0.14 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 1.25 Pain Relevance 0.21
However, recent reports suggest that changes occurring in immunosenescence including the accumulation of anergic CD8+ CD28?
Positive_regulation (accumulation) of Positive_regulation (anergic) of CD8
11) Confidence 0.14 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 1.24 Pain Relevance 0.21
The virus R3616 with the deletion of both ICP34.5 genes causes differences in the splenocyte subsets in comparison to the wild-type infection, inducing a stronger proliferation of CD4+ and CD8+T cells, as well as of the CD11c+ antigen presenting cells [334].
Positive_regulation (inducing) of Positive_regulation (proliferation) of CD8 in T cells associated with infection
12) Confidence 0.12 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.71 Pain Relevance 0.22
IRF-7 is essential for the induction of a systemic type-I Interferon (IFN-alpha/beta) response for innate antiviral immunity as well as the induction of a CD8+ T-cell response in adaptive immunity [31].
Positive_regulation (response) of Positive_regulation (induction) of CD8 in T-cell
13) Confidence 0.09 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.47 Pain Relevance 0.03

General Comments

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