INT56159

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Context Info
Confidence 0.51
First Reported 1994
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 3.23
Pain Relevance 4.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Scn2a1)
Anatomy Link Frequency
neurons 4
SCN 3
IGL 3
shell 1
Scn2a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 81 99.64 Very High Very High Very High
Serotonin 26 99.64 Very High Very High Very High
gABA 126 98.60 Very High Very High Very High
agonist 54 98.32 Very High Very High Very High
Spinal cord 18 97.44 Very High Very High Very High
5HT 24 97.24 Very High Very High Very High
Raphe 112 95.44 Very High Very High Very High
tetrodotoxin 7 91.96 High High
Eae 54 91.76 High High
antagonist 56 90.68 High High
Disease Link Frequency Relevance Heat
Injury 27 98.40 Very High Very High Very High
Urological Neuroanatomy 15 97.44 Very High Very High Very High
Stroke 219 93.00 High High
Congenital Anomalies 10 91.60 High High
Infarction 15 79.68 Quite High
Disease 49 77.36 Quite High
Brain Hemorrhage 6 77.12 Quite High
Ganglion Cysts 25 70.64 Quite High
Aging 37 64.08 Quite High
Targeted Disruption 27 56.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, the circadian rhythm of arginine vasopressin and vasoactive intestinal polypeptide release in cultured SCN is regulated by different populations that can desynchronize from each other [19,20].
Regulation (regulated) of SCN
1) Confidence 0.51 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1456999 Disease Relevance 0 Pain Relevance 0.05
A recent study [264] demonstrated that the molecular rhythm of PK2 in the SCN is regulated by both circadian clock and light, with the clock having a predominant role and light having a modulatory role.
Regulation (regulated) of SCN
2) Confidence 0.38 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.29
This suggests that an intrinsic, spontaneously active neuronal mechanism in the SCN is responsible for the cAMP- and depolarization-dependent pathways involved in maintaining peak VP gene transcription.
Regulation (responsible) of SCN in SCN
3) Confidence 0.29 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17202481 Disease Relevance 0 Pain Relevance 0.39
Finally, novel genetic polymorphisms in outbred Wistar rats may impact the responses of SCN neurons to cortical and basal ganglial injury.
Regulation (responses) of SCN in neurons associated with injury
4) Confidence 0.29 Published 2008 Journal J Circadian Rhythms Section Body Doc Link PMC2584098 Disease Relevance 0.91 Pain Relevance 0.27
Serotonin is also found to regulate SCN neurons by both pre- and post synaptic inhibitory mechanisms [135]. 5HT and 5HT agonists are also found to inhibit optic nerve-induced field potentials in the SCN brain slice preparation, and light-induced Fos expression and phase shifts of the circadian rhythm of wheel-running activity [136].
Regulation (regulate) of SCN in neurons associated with agonist, 5ht and serotonin
5) Confidence 0.28 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.62
The possibility that endogenous little SAAS levels might modulate SCN susceptibility to phase resetting deserves further evaluation.
Spec (might) Regulation (modulate) of SCN
6) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935382 Disease Relevance 0 Pain Relevance 0.10
Here, we show that several agents administered in a profile consistent with activity at the 5-HT7 receptor produce significant functional Fos immunoreactivity in the suprachiasmatic nucleus (SCN), an effect reduced upon chronic exposure.
Regulation (immunoreactivity) of SCN in SCN
7) Confidence 0.23 Published 1999 Journal Neuropsychopharmacology Section Abstract Doc Link 10457532 Disease Relevance 0 Pain Relevance 0.28
Together these data support the hypothesis that SCN clock sensitivity to serotonergic phase modulation is affected by the amount of prior serotonin signaling present in the SCN, and that this signaling alters the density of surface 5-HT receptors on SCN clock neurons.
Regulation (affected) of SCN in SCN associated with serotonin
8) Confidence 0.23 Published 2006 Journal Neuroscience Section Abstract Doc Link 16876330 Disease Relevance 0 Pain Relevance 0.29
The organization of the IGL and its connections as revealed in this analysis is in accord with its role in the integration of visual input with other information to provide feedback regulation of the SCN pacemaker.
Regulation (regulation) of SCN in IGL
9) Confidence 0.20 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 8063960 Disease Relevance 0.07 Pain Relevance 0.33
In addition, the thalamic intergeniculate leaflet (IGL) [20] modulates SCN activity, which may affect melatonin output.
Regulation (modulates) of SCN in IGL
10) Confidence 0.17 Published 2008 Journal J Circadian Rhythms Section Body Doc Link PMC2584098 Disease Relevance 0.93 Pain Relevance 0.12
In addition, the thalamic intergeniculate leaflet (IGL) [20] modulates SCN activity, which may affect melatonin output.
Spec (may) Regulation (affect) of SCN in IGL
11) Confidence 0.17 Published 2008 Journal J Circadian Rhythms Section Body Doc Link PMC2584098 Disease Relevance 0.99 Pain Relevance 0.12
Use of the acetylcholine receptor agonist carbachol, a non-specific agonist, to mimic the effects of light [109] also added to the supporting evidence for the role of acetylcholine in the SCN.
Regulation (role) of SCN associated with agonist
12) Confidence 0.17 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.37
Presence of neurons showing nitric oxide synthase (nNOS) immunoreactivity in the SCN of dwarf hamster and rat [58,59] were further confirmed by the studies of Chen and co-workers [60] and Caillol and co-workers [61].
Regulation (immunoreactivity) of SCN in neurons
13) Confidence 0.17 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0.07 Pain Relevance 0.49
Together, the alteration in SCN input results in a disinhibition of orexin neurons leading to arousal and priming of the animals behavior for waking.
Regulation (alteration) of SCN in neurons
14) Confidence 0.14 Published 2008 Journal Mol Brain Section Body Doc Link PMC2632999 Disease Relevance 0 Pain Relevance 0.04
A PCR analys is of the mRNA isolated from the rat SCN found evidence for the expression of two PAC1 isoforms including the PAC1null splice variant [47].
Regulation (isolated) of SCN
15) Confidence 0.13 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0 Pain Relevance 0.16
Thus, neuropeptides are predicted to participate in SCN functions to an unusual degree [3].
Regulation (participate) of SCN associated with neuropeptide
16) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935382 Disease Relevance 0.14 Pain Relevance 0.09
Qualitatively, the area most prominently suppressed by the dark pulse appeared to be the rostral SCN and preliminary inspections indicated both 'core' and 'shell' regions [23] of the mid-rostrocaudal SCN were similarly affected by the dark pulse (data not shown).
Regulation (affected) of SCN in shell
17) Confidence 0.06 Published 2008 Journal Mol Brain Section Body Doc Link PMC2632999 Disease Relevance 0 Pain Relevance 0.26
Earlier studies already reported that the photoperiod [32] and the feeding-fasting rhythm [15], [16], [17] differentially regulate peripheral clocks and the central SCN pacemaker.
Regulation (regulate) of SCN
18) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3002272 Disease Relevance 0.06 Pain Relevance 0
Age alters the 24-h expression profile of CLOCK and its binding partner BMAL1 in the hamster SCN, but there is no effect of age on the 24-h profile of either Per1 or Per2 proteins when hamsters are housed in constant darkness.
Regulation (alters) of SCN
19) Confidence 0.03 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC2995617 Disease Relevance 0.05 Pain Relevance 0

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