INT5617

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Context Info
Confidence 0.81
First Reported 1985
Last Reported 2010
Negated 3
Speculated 8
Reported most in Abstract
Documents 266
Total Number 274
Disease Relevance 83.51
Pain Relevance 83.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
heart 23
plasma 16
cardiomyocytes 11
blood 9
neurons 8
Nppa (Rattus norvegicus)
Nppa - S99Y (1)
Pain Link Frequency Relevance Heat
Somatostatin 143 100.00 Very High Very High Very High
Enkephalin 75 100.00 Very High Very High Very High
Opioid 31 100.00 Very High Very High Very High
Neuropeptide 26 100.00 Very High Very High Very High
substance P 22 100.00 Very High Very High Very High
Calcitonin gene-related peptide 22 100.00 Very High Very High Very High
Spinal cord 14 100.00 Very High Very High Very High
calcitonin gene related peptide 9 100.00 Very High Very High Very High
agonist 251 99.90 Very High Very High Very High
Dynorphin 118 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 625 100.00 Very High Very High Very High
Pressure And Volume Under Development 27 100.00 Very High Very High Very High
Cirrhosis 6 100.00 Very High Very High Very High
Hypertension 158 99.84 Very High Very High Very High
Heart Rate Under Development 63 99.84 Very High Very High Very High
Aging 6 99.84 Very High Very High Very High
Myocardial Infarction 146 99.76 Very High Very High Very High
Injury 4 99.76 Very High Very High Very High
Sprains And Strains 21 99.60 Very High Very High Very High
Hypertrophy 22 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A long-term effect of pentobarbital treatment on the storage and release of atrial natriuretic peptide (ANP) was investigated in rats.
Localization (release) of ANP associated with natriuresis
1) Confidence 0.81 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 8115351 Disease Relevance 0.23 Pain Relevance 0.07
A long-term effect of pentobarbital treatment on the storage and release of atrial natriuretic peptide (ANP) was investigated in rats.
Localization (release) of atrial natriuretic peptide associated with natriuresis
2) Confidence 0.81 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 8115351 Disease Relevance 0.23 Pain Relevance 0.07
These results indicate that pentobarbital may have a long-term effect on the storage and release of ANP.
Localization (release) of ANP
3) Confidence 0.81 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 8115351 Disease Relevance 0.40 Pain Relevance 0.07
A decrease of blood pressure and heart rate and a suppression of ANF release elicited by clonidine were significantly greater in SHRsp than in WKY rats.
Localization (release) of ANF in blood associated with clonidine
4) Confidence 0.81 Published 1991 Journal Sheng Li Xue Bao Section Abstract Doc Link 1836674 Disease Relevance 0.58 Pain Relevance 0.60
After blockade of alpha 2-receptor with yohimbine, the hypotensive effect of clonidine was blocked completely in WKY rats, but only partially in SHRsp, while the suppression effect on ANF release was eliminated in both strains.
Localization (release) of ANF associated with hypotension, sprains and strains and clonidine
5) Confidence 0.81 Published 1991 Journal Sheng Li Xue Bao Section Abstract Doc Link 1836674 Disease Relevance 0.56 Pain Relevance 0.63
[Changes of the release of atrial natriuretic factor (ANF) and its gene transcription in morphine tolerance rat atrium].
Localization (release) of ANF in atrium associated with natriuresis, tolerance and morphine
6) Confidence 0.81 Published 1989 Journal Sheng Li Xue Bao Section Title Doc Link 2533995 Disease Relevance 0.10 Pain Relevance 0.40
[Changes of the release of atrial natriuretic factor (ANF) and its gene transcription in morphine tolerance rat atrium].
Localization (release) of atrial natriuretic factor in atrium associated with natriuresis, tolerance and morphine
7) Confidence 0.81 Published 1989 Journal Sheng Li Xue Bao Section Title Doc Link 2533995 Disease Relevance 0.10 Pain Relevance 0.40
In the presence of EGTA, 100 nM 12-O-tetradecanoylphorbol 13-acetate (TPA) significantly increased ANP secretion; this increment was unaffected by 100 microM ryanodine.
Localization (secretion) of ANP
8) Confidence 0.81 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2466408 Disease Relevance 0.14 Pain Relevance 0.17
Raising external Ca2+ concentration from 0.2 to 1.2 mM in the presence of tetrodotoxin did not increase ANP secretion.
Localization (secretion) of ANP in external associated with tetrodotoxin
9) Confidence 0.81 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2466408 Disease Relevance 0.16 Pain Relevance 0.19
Substantial ANP secretion persisted in a nominally Ca2+-free medium containing 10 mM ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA) and was not diminished by 100 microM ryanodine.
Localization (secretion) of ANP
10) Confidence 0.81 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2466408 Disease Relevance 0.16 Pain Relevance 0.19
Atrial natriuretic peptide (ANP) secretion by atrial myocytes in 7- to 8-day primary cultures from adult rats was measured by radioimmunoassay under conditions designed to separate primary effects on secretion from effects caused by contractions.
Localization (secretion) of Atrial natriuretic peptide in myocytes associated with natriuresis
11) Confidence 0.81 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2466408 Disease Relevance 0.17 Pain Relevance 0.15
These experiments suggest 1) that in absence of contractions, ANP secretion requires neither transplasmalemmal Ca2+ influx nor ryanodine-inhibitable Ca2+ release by sarcoplasmic reticulum (SR) and 2) that TPA stimulates ANP secretion without requiring Ca influx or ryanodine-inhibitable SR Ca release.
Localization (secretion) of ANP in reticulum
12) Confidence 0.81 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2466408 Disease Relevance 0.14 Pain Relevance 0.16
Atrial natriuretic peptide (ANP) secretion by atrial myocytes in 7- to 8-day primary cultures from adult rats was measured by radioimmunoassay under conditions designed to separate primary effects on secretion from effects caused by contractions.
Localization (secretion) of ANP in myocytes associated with natriuresis
13) Confidence 0.81 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2466408 Disease Relevance 0.17 Pain Relevance 0.15
These experiments suggest 1) that in absence of contractions, ANP secretion requires neither transplasmalemmal Ca2+ influx nor ryanodine-inhibitable Ca2+ release by sarcoplasmic reticulum (SR) and 2) that TPA stimulates ANP secretion without requiring Ca influx or ryanodine-inhibitable SR Ca release.
Localization (secretion) of ANP in reticulum
14) Confidence 0.81 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2466408 Disease Relevance 0.13 Pain Relevance 0.14
Incubation of spontaneously beating ventricular cardiomyocytes from neonatal rats with prostaglandin E(2) (0.1 microM) or forskolin (0.1 microM) simultaneously increased the rate of cellular contraction and atrial natriuretic peptide (ANP) secretion.
Localization (secretion) of ANP in cardiomyocytes associated with natriuresis
15) Confidence 0.81 Published 2000 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 10644591 Disease Relevance 0.17 Pain Relevance 0.05
Moreover, in quiescent cultures that were pretreated with ryanodine, tetrodotoxin, nifedipine, or butanedione monoxime, prostaglandin E(2) (0.1 microM) and forskolin (0.1 microM) failed to elicit significant ANP secretion, suggesting that cAMP-elevating agents promote ANP secretion to a great extent via an increase in cellular contraction frequency in ventricular cardiomyocytes.
Localization (secretion) of ANP in cardiomyocytes associated with tetrodotoxin
16) Confidence 0.81 Published 2000 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 10644591 Disease Relevance 0.14 Pain Relevance 0.10
Incubation of spontaneously beating ventricular cardiomyocytes from neonatal rats with prostaglandin E(2) (0.1 microM) or forskolin (0.1 microM) simultaneously increased the rate of cellular contraction and atrial natriuretic peptide (ANP) secretion.
Localization (secretion) of atrial natriuretic peptide in cardiomyocytes associated with natriuresis
17) Confidence 0.81 Published 2000 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 10644591 Disease Relevance 0.17 Pain Relevance 0.05
Although distension of the venoatrial junction increased ANF secretion from the control atria, there was no such response in the denervated atria.
Localization (secretion) of ANF
18) Confidence 0.81 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 14749037 Disease Relevance 0.07 Pain Relevance 0.25
Capsaicin-sensitive neural pathway mediates atrial natriuretic factor (ANF) release in response to physiological stimuli.
Localization (release) of atrial natriuretic factor in neural associated with natriuresis and qutenza
19) Confidence 0.81 Published 2004 Journal Regul. Pept. Section Title Doc Link 14749037 Disease Relevance 0.10 Pain Relevance 0.33
Capsaicin-sensitive neural pathway mediates atrial natriuretic factor (ANF) release in response to physiological stimuli.
Localization (release) of ANF in neural associated with natriuresis and qutenza
20) Confidence 0.81 Published 2004 Journal Regul. Pept. Section Title Doc Link 14749037 Disease Relevance 0.10 Pain Relevance 0.33

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