INT5618

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Context Info
Confidence 0.62
First Reported 1986
Last Reported 2008
Negated 4
Speculated 13
Reported most in Abstract
Documents 36
Total Number 50
Disease Relevance 13.42
Pain Relevance 17.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
neurons 10
plasma 6
blood 6
lung 6
heart 6
Nppa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 77 100.00 Very High Very High Very High
agonist 49 100.00 Very High Very High Very High
Dynorphin 21 100.00 Very High Very High Very High
cva 4 100.00 Very High Very High Very High
opiate 1 100.00 Very High Very High Very High
dexamethasone 40 99.96 Very High Very High Very High
opioid receptor 19 99.84 Very High Very High Very High
Opioid 7 99.84 Very High Very High Very High
Endogenous opioid 6 99.84 Very High Very High Very High
anesthesia 11 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 100 100.00 Very High Very High Very High
Hypertension 42 99.84 Very High Very High Very High
Heart Rate Under Development 10 99.60 Very High Very High Very High
Schizophrenia 6 99.50 Very High Very High Very High
Sprains And Strains 6 99.04 Very High Very High Very High
Hypotension 1 97.84 Very High Very High Very High
Diuresis 7 96.64 Very High Very High Very High
Myocardial Infarction 6 96.28 Very High Very High Very High
Shock 2 96.16 Very High Very High Very High
Cv General 3 Under Development 3 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After blockade of alpha 2-receptor with yohimbine, the hypotensive effect of clonidine was blocked completely in WKY rats, but only partially in SHRsp, while the suppression effect on ANF release was eliminated in both strains.
Regulation (effect) of Localization (release) of ANF associated with hypotension, sprains and strains and clonidine
1) Confidence 0.62 Published 1991 Journal Sheng Li Xue Bao Section Abstract Doc Link 1836674 Disease Relevance 0.56 Pain Relevance 0.63
The aim of this study was to define the possible role of I(1)-imidazoline receptors in the regulation of atrial natriuretic peptide (ANP) release in hypertrophied atria.
Spec (possible) Regulation (regulation) of Localization (release) of ANP associated with natriuresis
2) Confidence 0.62 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 14975931 Disease Relevance 0.46 Pain Relevance 0.21
Moreover, the decrease of basal plasma IR-ANF suggests the possible implication of endogenous opioids in the regulation of basal ANF secretion.
Regulation (regulation) of Localization (secretion) of ANF in plasma associated with endogenous opioid
3) Confidence 0.62 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2949987 Disease Relevance 0.15 Pain Relevance 0.71
Recent studies have led to the suggestion that the peptidergic innervation of the heart, through the release of peptides, may be involved in the control of ANF secretion.
Regulation (control) of Localization (secretion) of ANF in heart
4) Confidence 0.62 Published 1990 Journal Regul. Pept. Section Abstract Doc Link 1703316 Disease Relevance 0.17 Pain Relevance 0.35
Capsaicin-sensitive nerves influence the release of atrial natriuretic factor by atrial stretch in the rat.
Regulation (influence) of Localization (release) of atrial natriuretic factor in nerves associated with natriuresis and qutenza
5) Confidence 0.62 Published 1990 Journal Regul. Pept. Section Title Doc Link 1703316 Disease Relevance 0.20 Pain Relevance 0.48
Although many factors may modulate the release of atrial natriuretic factor (ANF), the primary mechanism has been demonstrated to be atrial stretch.
Regulation (modulate) of Localization (release) of atrial natriuretic factor associated with natriuresis
6) Confidence 0.62 Published 1990 Journal Regul. Pept. Section Abstract Doc Link 1703316 Disease Relevance 0.17 Pain Relevance 0.15
To determine the effect of clonidine, an alpha 2-adrenergic agonist, on atrial natriuretic factor (ANF) release during water deprivation, plasma immunoreactive ANF (IR-ANF) arginine vasopressin, diuresis and natriuresis were measured in rats which had been deprived of water for 24 and 48 hr after intravenous (IV) administration of 50 micrograms clonidine.
Spec (determine) Regulation (effect) of Localization (release) of ANF in plasma associated with diuresis, natriuresis, agonist and clonidine
7) Confidence 0.62 Published 1988 Journal Peptides Section Abstract Doc Link 2856643 Disease Relevance 0.37 Pain Relevance 0.46
The clonidine's effect on ANF release may be mediated via activation of opioid receptors besides stimulation of alpha 2-adrenergic receptors.
Regulation (effect) of Localization (release) of ANF associated with opioid receptor and clonidine
8) Confidence 0.62 Published 1987 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3030313 Disease Relevance 0.07 Pain Relevance 0.66
The suppression of sodium and calcium channels and the resultant depressed excitability of the atrial cells may help to regulate ANP secretion.
Regulation (regulate) of Localization (secretion) of ANP associated with calcium channel
9) Confidence 0.62 Published 1990 Journal Science Section Abstract Doc Link 2154853 Disease Relevance 0.07 Pain Relevance 0.26
The presence of lidocaine (5 x 10(-4) M) had no effect on rate-induced ANF secretion.
Neg (no) Regulation (effect) of Localization (secretion) of ANF associated with lidocaine
10) Confidence 0.62 Published 1989 Journal Circ. Res. Section Abstract Doc Link 2522835 Disease Relevance 0.07 Pain Relevance 0.15
Neither isoproterenol (beta 1 + beta 2 agonist) nor clonidine (alpha 2 agonist) had any effect on ANF release in the heart-lung preparation.
Regulation (effect) of Localization (release) of ANF in lung associated with agonist and clonidine
11) Confidence 0.61 Published 1988 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2971217 Disease Relevance 0.41 Pain Relevance 0.25
Our findings suggest that the opioid system affects ANF release in acute CHF.
Regulation (affects) of Localization (release) of ANF associated with heart rate under development and opioid
12) Confidence 0.59 Published 1993 Journal Eur. Heart J. Section Abstract Doc Link 8095454 Disease Relevance 0.73 Pain Relevance 0.92
The influence of anaesthesia and major vascular surgery on the release and circulation of ANF is unknown.
Regulation (influence) of Localization (release) of ANF
13) Confidence 0.55 Published 1993 Journal Minerva Anestesiol Section Abstract Doc Link 8515849 Disease Relevance 0.18 Pain Relevance 0.12
Dynorphin, an endogenous opioid peptide, acts on specific kappa-opioid receptors in the rat heart for the local regulation of atrial natriuretic peptide release.
Regulation (regulation) of Localization (release) of atrial natriuretic peptide in heart associated with natriuresis, dynorphin, kappa opioid receptor and endogenous opioid
14) Confidence 0.54 Published 1993 Journal Clin. Sci. Section Abstract Doc Link 7908617 Disease Relevance 0.16 Pain Relevance 0.35
A long-term effect of pentobarbital treatment on the storage and release of atrial natriuretic peptide (ANP) was investigated in rats.
Regulation (effect) of Localization (release) of atrial natriuretic peptide associated with natriuresis
15) Confidence 0.45 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 8115351 Disease Relevance 0.23 Pain Relevance 0.07
A long-term effect of pentobarbital treatment on the storage and release of atrial natriuretic peptide (ANP) was investigated in rats.
Regulation (effect) of Localization (release) of ANP associated with natriuresis
16) Confidence 0.45 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 8115351 Disease Relevance 0.23 Pain Relevance 0.07
[Changes of the release of atrial natriuretic factor (ANF) and its gene transcription in morphine tolerance rat atrium].
Regulation ([Changes) of Localization (release) of atrial natriuretic factor in atrium associated with natriuresis, tolerance and morphine
17) Confidence 0.45 Published 1989 Journal Sheng Li Xue Bao Section Title Doc Link 2533995 Disease Relevance 0.10 Pain Relevance 0.40
[Changes of the release of atrial natriuretic factor (ANF) and its gene transcription in morphine tolerance rat atrium].
Regulation ([Changes) of Localization (release) of ANF in atrium associated with natriuresis, tolerance and morphine
18) Confidence 0.45 Published 1989 Journal Sheng Li Xue Bao Section Title Doc Link 2533995 Disease Relevance 0.10 Pain Relevance 0.40
The aim of this study was to define the possible role of I(1)-imidazoline receptors in the regulation of atrial natriuretic peptide (ANP) release in hypertrophied atria.
Spec (possible) Regulation (regulation) of Localization (release) of atrial natriuretic peptide associated with natriuresis
19) Confidence 0.45 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 14975931 Disease Relevance 0.46 Pain Relevance 0.21
Although many factors may modulate the release of atrial natriuretic factor (ANF), the primary mechanism has been demonstrated to be atrial stretch.
Regulation (modulate) of Localization (release) of ANF associated with natriuresis
20) Confidence 0.45 Published 1990 Journal Regul. Pept. Section Abstract Doc Link 1703316 Disease Relevance 0.17 Pain Relevance 0.15

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