INT5619

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Context Info
Confidence 0.70
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 11.95
Pain Relevance 4.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
plasma 8
heart 6
olfactory bulb 4
BNP 2
EPI 2
Nppa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 8 99.96 Very High Very High Very High
anesthesia 12 99.90 Very High Very High Very High
halothane 4 99.68 Very High Very High Very High
Inflammatory response 3 99.52 Very High Very High Very High
Angina 7 99.28 Very High Very High Very High
Catecholamine 3 99.24 Very High Very High Very High
Morphine 9 98.36 Very High Very High Very High
Dopamine 1 96.24 Very High Very High Very High
agonist 19 95.32 Very High Very High Very High
Neurotransmitter 2 94.40 High High
Disease Link Frequency Relevance Heat
Natriuresis 66 100.00 Very High Very High Very High
Coronary Artery Disease 32 100.00 Very High Very High Very High
Body Weight 5 100.00 Very High Very High Very High
Heart Rate Under Development 19 99.96 Very High Very High Very High
INFLAMMATION 15 99.52 Very High Very High Very High
Left Ventricular Hypertrophy 1 99.52 Very High Very High Very High
Cv General 3 Under Development 6 99.28 Very High Very High Very High
Myocardial Infarction 199 99.24 Very High Very High Very High
Congenital Anomalies 15 97.84 Very High Very High Very High
Hypertrophy 37 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that the biosynthesis and storage of ANF in atria be increased and its release from atria decreased in morphine tolerant rats.
Positive_regulation (increased) of Gene_expression (biosynthesis) of ANF associated with morphine
1) Confidence 0.70 Published 1989 Journal Sheng Li Xue Bao Section Abstract Doc Link 2533995 Disease Relevance 0.07 Pain Relevance 0.40
These data suggest that these stimuli can change ANP gene expression in the auricles and that the changes are induced differentially in both auricles.
Positive_regulation (change) of Gene_expression (expression) of ANP in auricles
2) Confidence 0.70 Published 1991 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1839321 Disease Relevance 0.15 Pain Relevance 0.34
Consequently, the estimated cardiac release and cardiac production of immunoreactive atrial natriuretic factor were strikingly increased in cirrhotics (13,334 +/- 2,007 and 5,484 +/- 1,734 fmoles per min, respectively) as compared to control subjects (1,669 +/- 338 and 1,431 +/- 350 fmoles per min, respectively; p less than 0.01).
Positive_regulation (increased) of Gene_expression (production) of atrial natriuretic factor associated with natriuresis
3) Confidence 0.55 Published 1988 Journal Hepatology Section Abstract Doc Link 2967242 Disease Relevance 0.83 Pain Relevance 0.06
We report here that norepinephrine or epinephrine (NE/EPI) facilitates irANP secretion and pro-ANP mRNA expression in long term cultures of rat hypothalamic neurons through their effects on alpha 2-adrenoceptors.
Positive_regulation (facilitates) of Gene_expression (expression) of ANP in EPI
4) Confidence 0.48 Published 1992 Journal Endocrinology Section Abstract Doc Link 1312457 Disease Relevance 0.07 Pain Relevance 0.10
Compared with control subjects, on admission patients showed increased plasma levels of ANP, as well as increased plasma renin activity (PRA), aldosterone, norepinephrine, epinephrine, dopamine, and antidiuretic hormone (ADH).
Positive_regulation (increased) of Gene_expression (levels) of ANP in plasma associated with dopamine
5) Confidence 0.40 Published 1991 Journal Eur. Heart J. Section Abstract Doc Link 1829681 Disease Relevance 0.77 Pain Relevance 0.19
Aortic banding increased left ventricular expression of NPR-A and NPR-C mRNA by 110% (P < 0.001) and 520% (P < 0.01), respectively, after 8 wk; as expected, it also increased the expression of ANP and BNP mRNAs.
Positive_regulation (increased) of Gene_expression (expression) of ANP in BNP
6) Confidence 0.39 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.79 Pain Relevance 0.24
ANP levels in patients with CAD are increased, even if clinical heart failure symptoms are absent. 2.
Positive_regulation (increased) of Gene_expression (levels) of ANP in heart associated with coronary artery disease and myocardial infarction
7) Confidence 0.36 Published 1992 Journal Anaesthesist Section Abstract Doc Link 1489072 Disease Relevance 0.43 Pain Relevance 0.07
In contrast, during 2.2% halothane anesthesia the increase in plasma ANP produced by volume loading was greater and the decrease in AII was abolished.
Positive_regulation (increase) of Gene_expression (produced) of ANP in plasma associated with anesthesia and halothane
8) Confidence 0.35 Published 1989 Journal Anesth. Analg. Section Abstract Doc Link 2521280 Disease Relevance 0.24 Pain Relevance 0.68
Left ventricular hypertrophy was associated with an increase in ANP expression and low plasma renin activity, indicative of a volume overload in post-infarct GK rats, a feature that was not present in non-diabetic Wistar rats.
Positive_regulation (increase) of Gene_expression (expression) of ANP in plasma associated with left ventricular hypertrophy and diabetes mellitus
9) Confidence 0.33 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.10 Pain Relevance 0.04
Their injection also induced a significant increase in plasma ANP concentration and in ANP content in the olfactory bulb (OB), AV3V, medial basal hypothalamus (MBH) and median eminence (ME).
Positive_regulation (increase) of Gene_expression (content) of ANP in olfactory bulb
10) Confidence 0.30 Published 2001 Journal Brain Res. Section Abstract Doc Link 11259763 Disease Relevance 0.20 Pain Relevance 0.34
Their injection also induced a significant increase in plasma ANP concentration and in ANP content in the olfactory bulb (OB), AV3V, medial basal hypothalamus (MBH) and median eminence (ME).
Positive_regulation (increase) of Gene_expression (content) of ANP in olfactory bulb
11) Confidence 0.30 Published 2001 Journal Brain Res. Section Abstract Doc Link 11259763 Disease Relevance 0.20 Pain Relevance 0.34
Constriction of the ascending aorta of rats resulted in an increase in the heart weight to body weight ratio, increased myocyte diameter, re-expression of the fetal genes ANF, MHCbeta and skeletal alpha-actin, and decreased expression of the adult genes GLUT4 and SERCA2a.
Positive_regulation (increase) of Gene_expression (expression) of ANF in body associated with body weight
12) Confidence 0.28 Published 2001 Journal Mol. Cell. Biochem. Section Abstract Doc Link 11716363 Disease Relevance 0.42 Pain Relevance 0.35
Atrial natriuretic peptide (ANP) is primarily produced in both atria; production and release of ANP is typically triggered by increased atrial-wall tension typically following an increase of intravascular volume or pressure.
Positive_regulation (triggered) of Gene_expression (production) of ANP associated with natriuresis
13) Confidence 0.27 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716780 Disease Relevance 1.23 Pain Relevance 0
Plasma levels of ANP and BNP are elevated in patients with unstable angina, acute myocardial infarction, and with congestive heart failure.
Positive_regulation (elevated) of Gene_expression (levels) of ANP in heart associated with heart rate under development, angina and myocardial infarction
14) Confidence 0.18 Published 2000 Journal Ther Umsch Section Abstract Doc Link 10859990 Disease Relevance 1.06 Pain Relevance 0.10
Interleukin-18 in patients with congestive heart failure: induction of atrial natriuretic peptide gene expression.
Positive_regulation (induction) of Gene_expression (expression) of atrial natriuretic peptide in heart associated with natriuresis and heart rate under development
15) Confidence 0.14 Published 2000 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Title Doc Link 11758978 Disease Relevance 0.91 Pain Relevance 0.19
Very modest increases in TSH were detected on PND21 but were more variable and failed to reach statistically significant levels [F(3, 87) = 1.23; p > 0.30].
Positive_regulation (increases) of Gene_expression (detected) of PND21
16) Confidence 0.14 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430231 Disease Relevance 0 Pain Relevance 0
Here, we report that dexamethasone (DM) modulates irANP secretion and pro-ANP mRNA expression from hypothalamic neurons in culture by switching the adrenoceptor responsiveness of the cells from alpha 2- to that of beta-AR.
Positive_regulation (modulates) of Gene_expression (expression) of irANP in neurons associated with dexamethasone
17) Confidence 0.13 Published 1992 Journal Endocrinology Section Abstract Doc Link 1324165 Disease Relevance 0.08 Pain Relevance 0.46
Increased expression of ANP mRNA was demonstrated in IL-18 treated myocytes.
Positive_regulation (Increased) of Gene_expression (expression) of ANP in myocytes
18) Confidence 0.12 Published 2000 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 11758978 Disease Relevance 0.78 Pain Relevance 0.15
A decrease of fractional shortening and increased levels of IrANP are late phenomena.
Positive_regulation (increased) of Gene_expression (levels) of IrANP
19) Confidence 0.07 Published 1987 Journal Acta Med. Scand. Suppl. Section Abstract Doc Link 2962421 Disease Relevance 1.12 Pain Relevance 0.07
Atrial natriuretic peptide expression was increased in CERA-treated mice.
Positive_regulation (increased) of Gene_expression (expression) of Atrial natriuretic peptide associated with natriuresis
20) Confidence 0.05 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 1.30 Pain Relevance 0.04

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