INT5620

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Context Info
Confidence 0.70
First Reported 1987
Last Reported 2010
Negated 7
Speculated 6
Reported most in Abstract
Documents 105
Total Number 111
Disease Relevance 30.23
Pain Relevance 36.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
heart 16
plasma 12
cardiac myocytes 10
sympathetic 8
neural 6
Nppa (Rattus norvegicus)
Nppa - S99Y (1)
Pain Link Frequency Relevance Heat
antagonist 100 100.00 Very High Very High Very High
Morphine 38 100.00 Very High Very High Very High
Kappa opioid receptor 27 100.00 Very High Very High Very High
anesthesia 14 100.00 Very High Very High Very High
opiate 8 100.00 Very High Very High Very High
Clonidine 159 99.98 Very High Very High Very High
Dynorphin 54 99.98 Very High Very High Very High
agonist 137 99.96 Very High Very High Very High
Catecholamine 16 99.92 Very High Very High Very High
tetrodotoxin 14 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 251 100.00 Very High Very High Very High
Aging 2 99.84 Very High Very High Very High
Sprains And Strains 10 99.60 Very High Very High Very High
Hypertrophy 16 99.56 Very High Very High Very High
Diuresis 38 99.00 Very High Very High Very High
Pressure And Volume Under Development 12 98.80 Very High Very High Very High
Coronary Artery Disease 4 98.80 Very High Very High Very High
Heart Rate Under Development 22 98.58 Very High Very High Very High
Hypertension 59 98.48 Very High Very High Very High
Overactive Bladder 52 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the presence of EGTA, 100 nM 12-O-tetradecanoylphorbol 13-acetate (TPA) significantly increased ANP secretion; this increment was unaffected by 100 microM ryanodine.
Positive_regulation (increased) of Localization (secretion) of ANP
1) Confidence 0.70 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2466408 Disease Relevance 0.15 Pain Relevance 0.17
Raising external Ca2+ concentration from 0.2 to 1.2 mM in the presence of tetrodotoxin did not increase ANP secretion.
Neg (not) Positive_regulation (increase) of Localization (secretion) of ANP in external associated with tetrodotoxin
2) Confidence 0.70 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2466408 Disease Relevance 0.16 Pain Relevance 0.19
These experiments suggest 1) that in absence of contractions, ANP secretion requires neither transplasmalemmal Ca2+ influx nor ryanodine-inhibitable Ca2+ release by sarcoplasmic reticulum (SR) and 2) that TPA stimulates ANP secretion without requiring Ca influx or ryanodine-inhibitable SR Ca release.
Positive_regulation (stimulates) of Localization (secretion) of ANP in reticulum
3) Confidence 0.70 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2466408 Disease Relevance 0.13 Pain Relevance 0.14
Incubation of spontaneously beating ventricular cardiomyocytes from neonatal rats with prostaglandin E(2) (0.1 microM) or forskolin (0.1 microM) simultaneously increased the rate of cellular contraction and atrial natriuretic peptide (ANP) secretion.
Positive_regulation (increased) of Localization (secretion) of atrial natriuretic peptide in cardiomyocytes associated with natriuresis
4) Confidence 0.70 Published 2000 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 10644591 Disease Relevance 0.17 Pain Relevance 0.05
Although distension of the venoatrial junction increased ANF secretion from the control atria, there was no such response in the denervated atria.
Positive_regulation (increased) of Localization (secretion) of ANF
5) Confidence 0.70 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 14749037 Disease Relevance 0.07 Pain Relevance 0.25
We conclude (A) that local application of capsaicin to the heart of adult rats induces selective functional neural deficits and (B) that information regarding distension of the junction of the great veins and the atria is normally transmitted across the atrium via these nerves to stimulate ANF secretion from peptide stores located in the atrial appendage.
Positive_regulation (stimulate) of Localization (secretion) of ANF in heart associated with qutenza
6) Confidence 0.70 Published 2004 Journal Regul. Pept. Section Abstract Doc Link 14749037 Disease Relevance 0.07 Pain Relevance 0.24
Capsaicin-sensitive neural pathway mediates atrial natriuretic factor (ANF) release in response to physiological stimuli.
Positive_regulation (mediates) of Localization (release) of ANF in neural associated with natriuresis and qutenza
7) Confidence 0.70 Published 2004 Journal Regul. Pept. Section Title Doc Link 14749037 Disease Relevance 0.10 Pain Relevance 0.33
Augmentation of moxonidine-induced increase in ANP release by atrial hypertrophy.
Positive_regulation (increase) of Localization (release) of ANP associated with hypertrophy
8) Confidence 0.70 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Title Doc Link 14975931 Disease Relevance 0.45 Pain Relevance 0.21
These results show that moxonidine increases ANP release through (preferentially) the activation of atrial I(1)-imidazoline receptors and also via different mechanisms from clonidine, and this effect is augmented in hypertrophied atria.
Positive_regulation (increases) of Localization (release) of ANP associated with clonidine
9) Confidence 0.70 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 14975931 Disease Relevance 0.22 Pain Relevance 0.29
Pretreatment with efaroxan (a selective I(1)-imidazoline receptor antagonist) or rauwolscine (a selective alpha(2)-adrenoceptor antagonist) inhibited the moxonidine-induced increases in ANP secretion and interstitial ANP concentration and decrease in pulse pressure.
Positive_regulation (increases) of Localization (secretion) of ANP associated with antagonist
10) Confidence 0.70 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 14975931 Disease Relevance 0.43 Pain Relevance 0.28
Moxonidine (3, 10, and 30 micromol/l) also caused dose-dependent increases in ANP secretion, but clonidine (an alpha(2)-adrenoceptor agonist) did not.
Positive_regulation (increases) of Localization (secretion) of ANP associated with agonist and clonidine
11) Confidence 0.70 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 14975931 Disease Relevance 0.42 Pain Relevance 0.28
However, the antagonistic effect of efaroxan on moxonidine-induced ANP secretion was greater than that of rauwolscine.
Positive_regulation (induced) of Localization (secretion) of ANP
12) Confidence 0.70 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 14975931 Disease Relevance 0.42 Pain Relevance 0.26
We conclude that the diuresis induced by i.c.v. administration of morphine is due to enhanced release of ANF.
Positive_regulation (enhanced) of Localization (release) of ANF associated with diuresis and morphine
13) Confidence 0.70 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8223938 Disease Relevance 0.45 Pain Relevance 0.64
These results indicate the important role played by alpha 2-adrenergic receptors in mediating ANF release.
Positive_regulation (mediating) of Localization (release) of ANF
14) Confidence 0.70 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3035429 Disease Relevance 0.13 Pain Relevance 0.46
Morphine (10 mg/100 g body wt.) increased ANF secretion dramatically and equally in the two groups of pentobarbital anaesthetized (2 mg/100 g body wt.) rats.
Positive_regulation (increased) of Localization (secretion) of ANF in body associated with morphine
15) Confidence 0.70 Published 1990 Journal Regul. Pept. Section Abstract Doc Link 1965335 Disease Relevance 0.16 Pain Relevance 0.15
In conclusion, clonidine stimulates ANF release both in normally-hydrated and water-deprived rats.
Positive_regulation (stimulates) of Localization (release) of ANF associated with clonidine
16) Confidence 0.70 Published 1988 Journal Peptides Section Abstract Doc Link 2856643 Disease Relevance 0.36 Pain Relevance 0.71
Clonidine stimulates atrial natriuretic factor (ANF) release in water-deprived rats.
Positive_regulation (stimulates) of Localization (release) of atrial natriuretic factor associated with natriuresis and clonidine
17) Confidence 0.70 Published 1988 Journal Peptides Section Title Doc Link 2856643 Disease Relevance 0.49 Pain Relevance 0.67
These findings indicate that increased ANF release may be involved in the mechanism of clonidine-induced diuresis.
Positive_regulation (increased) of Localization (release) of ANF associated with diuresis and clonidine
18) Confidence 0.70 Published 1987 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3030313 Disease Relevance 0.17 Pain Relevance 0.67
The presence of lidocaine (5 x 10(-4) M) had no effect on rate-induced ANF secretion.
Positive_regulation (induced) of Localization (secretion) of ANF associated with lidocaine
19) Confidence 0.70 Published 1989 Journal Circ. Res. Section Abstract Doc Link 2522835 Disease Relevance 0.07 Pain Relevance 0.15
Our results show that at controlled resting tensions greater than 1 g, chronotropic stimulation increased IRANF secretion in a manner dependent on the pacing frequency; rapid atrial rates (e.g., 8 and 9 Hz) were necessary to release ANF at tensions of 1 g or less.
Positive_regulation (necessary) of Localization (release) of ANF
20) Confidence 0.70 Published 1989 Journal Circ. Res. Section Abstract Doc Link 2522835 Disease Relevance 0.15 Pain Relevance 0

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