INT56201

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Context Info
Confidence 0.31
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.97
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Glul) mitochondrion (Glul) lyase activity (Glul)
Golgi apparatus (Glul) intracellular (Glul) protein complex (Glul)
Anatomy Link Frequency
spinal cords 2
cortex 2
Glul (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 4 100.00 Very High Very High Very High
amygdala 2 100.00 Very High Very High Very High
Hippocampus 1 100.00 Very High Very High Very High
Morphine 5 99.68 Very High Very High Very High
narcan 8 99.40 Very High Very High Very High
cytokine 2 97.24 Very High Very High Very High
Antinociceptive 3 94.44 High High
excitatory amino acid 1 88.76 High High
cva 1 87.52 High High
Thermal hyperalgesia 2 87.28 High High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 2 100.00 Very High Very High Very High
Convulsion 3 96.52 Very High Very High Very High
Hyperalgesia 2 87.28 High High
Status Epilepticus 1 84.36 Quite High
Epilepsy 1 82.00 Quite High
Drug Induced Neurotoxicity 1 75.00 Quite High
Bordatella Infection 1 66.04 Quite High
INFLAMMATION 2 61.20 Quite High
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, ultra-low-dose naloxone plus morphine administration inhibited the downregulation of L-glutamate transporters (GTs) and the L-glutamate-metabolizing enzyme glutamine synthetase (GS), and, moreover, inhibited microglial activation and suppressed cytokine expression in PTX-treated rat spinal cords.
Negative_regulation (inhibited) of Negative_regulation (downregulation) of L-glutamate-metabolizing enzyme glutamine synthetase in spinal cords associated with glutamate, narcan, cytokine and morphine
1) Confidence 0.31 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 18216775 Disease Relevance 0.22 Pain Relevance 1.35
The marked reduction of glutamate decarboxylase (GAD; 53.3 +/- 12.2% of control) and choline acetyltransferase (ChAT; 60.9 +/- 9.1% of control) activities in amygdala/pyriform cortex and GAD activity in hippocampus (69.4 +/- 5.6% of control) observed 3 days after KA injection was abolished by BW755C treatment.
Negative_regulation (abolished) of Negative_regulation (reduction) of glutamate decarboxylase in cortex associated with glutamate, generalized anxiety disorder, hippocampus and amygdala
2) Confidence 0.18 Published 1994 Journal Brain Res. Section Abstract Doc Link 8069664 Disease Relevance 0.75 Pain Relevance 0.34

General Comments

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