INT5621

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Context Info
Confidence 0.50
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.97
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
myocytes 2
neurons 2
BNP 2
heart 2
Nppa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 1 92.64 High High
fibrosis 16 92.16 High High
anesthesia 5 87.72 High High
isoflurane 2 87.28 High High
Versed 1 86.84 High High
antagonist 7 86.72 High High
Angina 1 78.36 Quite High
cytokine 1 73.48 Quite High
Inflammatory response 1 68.04 Quite High
agonist 4 62.20 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 10 100.00 Very High Very High Very High
Myocardial Infarction 83 99.78 Very High Very High Very High
Hypertension 9 99.76 Very High Very High Very High
Heart Rate Under Development 7 96.52 Very High Very High Very High
Apoptosis 40 95.12 Very High Very High Very High
Diabetes Mellitus 55 94.64 High High
Fibrosis 14 92.16 High High
Hypertrophy 14 84.24 Quite High
Cv General 3 Under Development 1 78.36 Quite High
Coronary Heart Disease 14 76.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the failing right ventricle of the PH group, the expression of atrial natriuretic peptide (ANP) mRNA, which is a molecular marker for the failing heart, was markedly increased.
Positive_regulation (increased) of Transcription (expression) of ANP in heart associated with natriuresis and hypertension
1) Confidence 0.50 Published 2000 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 11078411 Disease Relevance 1.17 Pain Relevance 0.20
Norepinephrine stimulates immunoreactive (ir) atrial natriuretic peptide (ANP) secretion and pro-ANP mRNA expression from rat hypothalamic neurons in culture: effects of alpha 2-adrenoceptors.
Positive_regulation (stimulates) of Transcription (expression) of ANP in neurons associated with natriuresis
2) Confidence 0.45 Published 1992 Journal Endocrinology Section Title Doc Link 1312457 Disease Relevance 0.10 Pain Relevance 0.11
Aortic banding increased left ventricular expression of NPR-A and NPR-C mRNA by 110% (P < 0.001) and 520% (P < 0.01), respectively, after 8 wk; as expected, it also increased the expression of ANP and BNP mRNAs.
Positive_regulation (increased) of Transcription (expression) of ANP in BNP
3) Confidence 0.37 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.79 Pain Relevance 0.24
MI tended to increase ANP mRNA expression in Wistar and GK rats (Figure 2D).


Positive_regulation (increase) of Transcription (expression) of ANP associated with myocardial infarction
4) Confidence 0.33 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 2.13 Pain Relevance 0.05
Increased expression of ANP mRNA was demonstrated in IL-18 treated myocytes.
Positive_regulation (Increased) of Transcription (expression) of ANP in myocytes
5) Confidence 0.11 Published 2000 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 11758978 Disease Relevance 0.78 Pain Relevance 0.15

General Comments

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