INT56216

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Context Info
Confidence 0.67
First Reported 1994
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 6.72
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
blood 2
chest 1
skeletal muscle 1
heart 1
Tnnt3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 43 100.00 Very High Very High Very High
beta blocker 1 56.04 Quite High
depression 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 25 100.00 Very High Very High Very High
Myocardial Infarction 36 99.96 Very High Very High Very High
Coronary Artery Disease 24 99.68 Very High Very High Very High
Cv Unclassified Under Development 7 99.54 Very High Very High Very High
Diabetes Mellitus 6 98.92 Very High Very High Very High
Angina 18 98.88 Very High Very High Very High
Injury 14 97.64 Very High Very High Very High
Nicotine Addiction 5 97.40 Very High Very High Very High
Heart Disease 3 95.64 Very High Very High Very High
Cardiovascular Disease 4 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVE: It has been reported that the loss of cell membrane integrity during severe reversible ischaemia results in elevation of plasma troponin T (TnT) in unstable angina.
Positive_regulation (elevation) of TnT in plasma associated with angina and cv unclassified under development
1) Confidence 0.67 Published 2002 Journal Acta Cardiol Section Abstract Doc Link 11918128 Disease Relevance 0.35 Pain Relevance 0.10
CONCLUSION: Severe ischaemia does not result in the elevation of the plasma TnT level in patients with chronic CAD.


Positive_regulation (elevation) of TnT in plasma
2) Confidence 0.45 Published 2002 Journal Acta Cardiol Section Body Doc Link 11918128 Disease Relevance 0 Pain Relevance 0
Our findings showed that: a) 99% of healthy blood donors had TnT concentrations < 0.10 micrograms/L; b) the test had a high clinical efficiency in the diagnosis of acute myocardial infarction, with a sensitivity of 1.0 and a specificity of 0.88 at a decision level of 0.20 micrograms/L; c) serum TnT had a later peak value (8-38 h), but a wider diagnostic window (> 126 h) than the traditional markers considered in the study; d) serum TnT had an excellent sensitivity in the detection of microinfarctions in patients with unstable angina pectoris; e) the release patterns of serum TnT were qualitatively different in perfused versus nonperfused patients.
Positive_regulation (different) of TnT in blood associated with angina and myocardial infarction
3) Confidence 0.40 Published 1994 Journal Clin. Biochem. Section Abstract Doc Link 8070069 Disease Relevance 0.79 Pain Relevance 0.35
The serum concentration of TnT was compared to serum creatine kinase activity, creatine kinase MB (mass and activity), myoglobin concentration, and lactate dehydrogenase activity: in 77 patients with myocardial infarction (55 received thrombolytic treatment); in 32 patients with unstable angina; in 30 patients with nonischemic heart diseases; and in 40 patients with skeletal muscle injuries.
Positive_regulation (concentration) of TnT in skeletal muscle associated with angina, heart disease, injury and myocardial infarction
4) Confidence 0.40 Published 1994 Journal Clin. Biochem. Section Abstract Doc Link 8070069 Disease Relevance 0.58 Pain Relevance 0.09
Our findings showed that: a) 99% of healthy blood donors had TnT concentrations < 0.10 micrograms/L; b) the test had a high clinical efficiency in the diagnosis of acute myocardial infarction, with a sensitivity of 1.0 and a specificity of 0.88 at a decision level of 0.20 micrograms/L; c) serum TnT had a later peak value (8-38 h), but a wider diagnostic window (> 126 h) than the traditional markers considered in the study; d) serum TnT had an excellent sensitivity in the detection of microinfarctions in patients with unstable angina pectoris; e) the release patterns of serum TnT were qualitatively different in perfused versus nonperfused patients.
Positive_regulation (had) of TnT in blood associated with angina and myocardial infarction
5) Confidence 0.34 Published 1994 Journal Clin. Biochem. Section Abstract Doc Link 8070069 Disease Relevance 0.79 Pain Relevance 0.26
Patients with BNP in the higher quartiles were significantly older, had higher concentration of TnT exceeding 0.05 ng/mL, had diabetes mellitus, fewer were current smokers and they had a higher percentage of a previous history of heart failure, CVD and CHD.
Positive_regulation (concentration) of TnT in heart associated with coronary artery disease, nicotine addiction, cardiovascular disease, diabetes mellitus and myocardial infarction
6) Confidence 0.24 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2628862 Disease Relevance 0.75 Pain Relevance 0.09
In the patients with unstable coronary artery disease (unstable angina or prolonged chest pain attack) and conventional enzymes within normal limits, TnT was elevated in 14%, CK-MBm in 17% and both markers in 9%.
Positive_regulation (elevated) of TnT in chest associated with angina and coronary artery disease
7) Confidence 0.21 Published 1998 Journal Ann. Med. Section Abstract Doc Link 9814836 Disease Relevance 1.03 Pain Relevance 0.20
In the 60 patients with the diagnosis of a probable MI, TnT was elevated in 65%, CK-MBm in 67% and both markers in 60%.
Positive_regulation (elevated) of TnT associated with myocardial infarction
8) Confidence 0.12 Published 1998 Journal Ann. Med. Section Abstract Doc Link 9814836 Disease Relevance 1.00 Pain Relevance 0.18
TnT was elevated (> 0.10 microg/L) in 100%, CK-MBm (> 5.0 microg/L) in 99%, and both markers in 99% of the 89 patients with the diagnosis of a definite MI according to modified FINMONICA criteria.
Positive_regulation (elevated) of TnT associated with myocardial infarction
9) Confidence 0.12 Published 1998 Journal Ann. Med. Section Abstract Doc Link 9814836 Disease Relevance 0.81 Pain Relevance 0.14
IgG, IgA, or IgM titers did not correlate with concentrations of CRP or TnT.
Positive_regulation (concentrations) of TnT
10) Confidence 0.04 Published 2001 Journal Am. J. Cardiol. Section Abstract Doc Link 11356388 Disease Relevance 0.62 Pain Relevance 0.40

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