INT5622

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Context Info
Confidence 0.78
First Reported 1986
Last Reported 2010
Negated 1
Speculated 6
Reported most in Abstract
Documents 101
Total Number 107
Disease Relevance 49.46
Pain Relevance 25.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
plasma 25
brain 10
neurons 5
heart 4
cardiac myocyte 4
Nppa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 64 100.00 Very High Very High Very High
Central nervous system 15 100.00 Very High Very High Very High
Clonidine 29 99.98 Very High Very High Very High
dexamethasone 32 99.76 Very High Very High Very High
Spinal cord 39 99.70 Very High Very High Very High
Pain 73 99.64 Very High Very High Very High
anesthesia 59 99.64 Very High Very High Very High
nociceptor 2 99.64 Very High Very High Very High
Analgesic 9 99.58 Very High Very High Very High
ischemia 33 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 286 100.00 Very High Very High Very High
Acute Necrotizing Pancreatitis 34 100.00 Very High Very High Very High
Syndrome 55 99.96 Very High Very High Very High
Dyspnea 80 99.78 Very High Very High Very High
Heart Rate Under Development 76 99.70 Very High Very High Very High
Cv Unclassified Under Development 58 99.56 Very High Very High Very High
INFLAMMATION 80 99.52 Very High Very High Very High
Coronary Artery Disease 51 99.28 Very High Very High Very High
Left Ventricular Hypertrophy 4 99.28 Very High Very High Very High
Cv General 3 Under Development 60 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is suggested that the biosynthesis and storage of ANF in atria be increased and its release from atria decreased in morphine tolerant rats.
Gene_expression (biosynthesis) of ANF associated with morphine
1) Confidence 0.78 Published 1989 Journal Sheng Li Xue Bao Section Abstract Doc Link 2533995 Disease Relevance 0.07 Pain Relevance 0.40
These data suggest that these stimuli can change ANP gene expression in the auricles and that the changes are induced differentially in both auricles.
Gene_expression (expression) of ANP in auricles
2) Confidence 0.78 Published 1991 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1839321 Disease Relevance 0.15 Pain Relevance 0.34
In addition, ANF was found to be present in the hypophysial portal blood of anesthetized rats.
Gene_expression (present) of ANF in blood
3) Confidence 0.78 Published 1994 Journal Endocr Regul Section Abstract Doc Link 7711293 Disease Relevance 0.07 Pain Relevance 0.09
Atrial Natriuretic Peptide (ANP) or its smaller congeners are produced and secreted from the rat hypothalamus.
Gene_expression (produced) of ANP in hypothalamus associated with natriuresis
4) Confidence 0.75 Published 1992 Journal Endocrinology Section Abstract Doc Link 1324165 Disease Relevance 0.10 Pain Relevance 0.11
As the serum ghrelin levels in ANP are higher than in AEP, it can be used as a marker to show the severity of pancreatitis.
Gene_expression (levels) of ANP associated with pancreatitis and acute necrotizing pancreatitis
5) Confidence 0.75 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17333355 Disease Relevance 1.53 Pain Relevance 0.09
Although ANP or its smaller congeners are produced and secreted from rat hypothalami, the role or roles of neurotransmitter(s) in regulating their release and production from the neurons remains unclear.
Gene_expression (produced) of ANP in neurons associated with neurotransmitter
6) Confidence 0.75 Published 1992 Journal Endocrinology Section Abstract Doc Link 1312457 Disease Relevance 0.07 Pain Relevance 0.05
Although the renal expression of ANP was not changed significantly, that of NPR-A decreased significantly.
Gene_expression (expression) of ANP
7) Confidence 0.74 Published 2004 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 15053815 Disease Relevance 0.24 Pain Relevance 0.08
The distribution, biochemical properties, and developmental course of EC suggest that it may be involved in the synthesis of atrial natriuretic factor.
Gene_expression (synthesis) of atrial natriuretic factor associated with natriuresis
8) Confidence 0.69 Published 1988 Journal Endocrinology Section Abstract Doc Link 2967176 Disease Relevance 0.24 Pain Relevance 0.29
Although significant quantities of radioactivity were detected in the fetal plasma after maternal injections and in the maternal plasma after fetal injections of 125I-labelled synthetic ANP, no fraction of the placentally transferred radioactivity was due to intact ANP.
Gene_expression (detected) of ANP in plasma
9) Confidence 0.68 Published 1989 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2523752 Disease Relevance 0.17 Pain Relevance 0.10
The scorpion toxin at 10(-6) M induced a significant (p<0.01) increase (106%) in ANP levels.
Gene_expression (levels) of ANP
10) Confidence 0.68 Published 2008 Journal Peptides Section Abstract Doc Link 18191303 Disease Relevance 0.14 Pain Relevance 0.27
However, because differentiation of spinal cord motor neurons continues until PND10 (Mills and Sengelaub 1993) and the weight of the adult BC muscle is the most sensitive to Vz exposure during the GD16–17 period (Wolf et al. 2000), it is likely that the toxic window for Vz on erectile function spans the GD16–PND10 period.
Gene_expression (continues) of PND10 in muscle associated with spinal cord
11) Confidence 0.67 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257594 Disease Relevance 0.30 Pain Relevance 0.09
It was also found that ANF injection into the cuneate nucleus (20 of 38 sites) and the spinal trigeminal complex (28 of 42 sites) produced a decrease in MAP and HR that were of the same magnitude as those seen in the NTS.
Gene_expression (produced) of ANF in spinal
12) Confidence 0.67 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2969195 Disease Relevance 0.15 Pain Relevance 0.23
To obtain background data on plasma ANP and BNP levels in rats, we investigated the circadian rhythms and effects of anesthesia on these peptides.
Gene_expression (levels) of ANP in plasma associated with anesthesia
13) Confidence 0.67 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19952533 Disease Relevance 0.54 Pain Relevance 0.41
The plasma ANP and BNP levels were determined using a radioimmunoassay.
Gene_expression (levels) of ANP in plasma
14) Confidence 0.67 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19952533 Disease Relevance 0.48 Pain Relevance 0.45
The plasma ANP levels were high from the evening to early morning, while the plasma BNP levels were relatively low at 2:30 AM.
Gene_expression (levels) of ANP in plasma
15) Confidence 0.67 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19952533 Disease Relevance 0.47 Pain Relevance 0.44
The plasma ANP and BNP levels were determined using a radioimmunoassay.
Spec (determined) Gene_expression (determined) of ANP in plasma
16) Confidence 0.67 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19952533 Disease Relevance 0.48 Pain Relevance 0.45
The plasma level of the atrial natriuretic peptide (ANP) was measured in another group of rats.
Gene_expression (level) of atrial natriuretic peptide in plasma
17) Confidence 0.67 Published 2010 Journal Life Sci. Section Body Doc Link 20138185 Disease Relevance 0 Pain Relevance 0
Electrophoresis of RT-PCR products showed the presence of all 3 ANP receptor genes in both injected and control animals.
Gene_expression (presence) of ANP
18) Confidence 0.66 Published 2002 Journal Ann. Otol. Rhinol. Laryngol. Section Abstract Doc Link 12450181 Disease Relevance 0.16 Pain Relevance 0.09
The plasma level of the atrial natriuretic peptide (ANP) was measured in another group of rats.
Gene_expression (level) of ANP in plasma
19) Confidence 0.65 Published 2010 Journal Life Sci. Section Body Doc Link 20138185 Disease Relevance 0 Pain Relevance 0
Radioimmunoassay (RIA) was used to measure the plasma arginine vasopressin (AVP) and atrial natriuretic peptide (ANP) concentrations during the VE.
Gene_expression (measure) of ANP in plasma
20) Confidence 0.65 Published 2010 Journal Acta Pharmacol. Sin. Section Body Doc Link 20023694 Disease Relevance 0 Pain Relevance 0

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