INT56221

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Context Info
Confidence 0.61
First Reported 1993
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 8
Total Number 11
Disease Relevance 8.44
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MPO) extracellular space (MPO) oxidoreductase activity (MPO)
aging (MPO) nucleus (MPO) lysosome (MPO)
Anatomy Link Frequency
peritoneal fluid 2
sputum 1
MPO (Homo sapiens)
Pain Link Frequency Relevance Heat
rapifen 4 100.00 Very High Very High Very High
Inflammation 84 99.60 Very High Very High Very High
cINOD 15 99.18 Very High Very High Very High
Opioid 1 97.76 Very High Very High Very High
cva 6 90.88 High High
abdominal pain 3 78.88 Quite High
methotrexate 6 57.04 Quite High
antagonist 1 37.76 Quite Low
Central nervous system 14 5.00 Very Low Very Low Very Low
headache 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 45 100.00 Very High Very High Very High
INFLAMMATION 87 99.60 Very High Very High Very High
Infection 24 99.12 Very High Very High Very High
Microscopic Polyangiitis 10 98.80 Very High Very High Very High
Syndrome 23 98.48 Very High Very High Very High
Stomach Cancer 29 98.40 Very High Very High Very High
Vasculitis 150 92.08 High High
Hemorrhage 2 90.88 High High
Renal Disease 12 88.80 High High
Loss Of Sense Of Smell 2 84.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The changes in concentration of hyaluronan (HYA) and myeloperoxidase in the peritoneal fluid (PF) were studied during genital intraperitoneal inflammation.
Regulation (changes) of myeloperoxidase in peritoneal fluid associated with inflammation
1) Confidence 0.61 Published 1994 Journal Inflammation Section Abstract Doc Link 8206644 Disease Relevance 0.45 Pain Relevance 0.20
Non-steroidal anti-inflammatory drugs (NSAIDs) were investigated for their ability to affect the chlorinating activity of human myeloperoxidase and to scavenge HOCl, the main myeloperoxidase system product.
Regulation (affect) of myeloperoxidase associated with inflammation and cinod
2) Confidence 0.54 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11301057 Disease Relevance 0.17 Pain Relevance 0.36
The present in vitro study was designed to assess the inhibition of the myeloperoxidase (MPO)/H(2)O(2)/Cl(-) system by several non steroidal anti-inflammatory drugs (NSAIDs) of the oxicam family and of nimesulide and to compare their effect with flufenamic acid in order to investigate their influence on the chlorinating activity of MPO as a protective mechanism during chronic inflammatory syndromes.
Spec (investigate) Regulation (influence) of MPO associated with inflammation, syndrome, cinod and urological neuroanatomy
3) Confidence 0.45 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17610876 Disease Relevance 0.70 Pain Relevance 0.45
We investigated the effect of fentanyl and alfentanil on superoxide anion production, hydrogen peroxide generation, and activity of released myeloperoxidase in vitro.
Spec (investigated) Regulation (effect) of myeloperoxidase associated with rapifen
4) Confidence 0.39 Published 1993 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 8391745 Disease Relevance 0.10 Pain Relevance 0.19
This further demonstrates that myeloperoxidase is an interesting target for anti-inflammatory therapy.
Regulation (target) of myeloperoxidase associated with inflammation
5) Confidence 0.27 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11301057 Disease Relevance 0.23 Pain Relevance 0.30
The changes in concentration of hyaluronan (HYA) and myeloperoxidase in peritoneal fluid (PF) were studied during genital intraperitoneal inflammation.
Regulation (changes) of myeloperoxidase in peritoneal fluid associated with inflammation
6) Confidence 0.27 Published 1994 Journal Inflammation Section Abstract Doc Link 8070899 Disease Relevance 0.45 Pain Relevance 0.20
Cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCAs) directed against proteinase 3 (PR3) are more commonly found in WGs whereas perinuclear ANCAs (p-ANCA) targeting myeloperoxidase (MPO) are more frequently seen in MPA and CSS.
Regulation (targeting) of MPO associated with syndrome, urological neuroanatomy and microscopic polyangiitis
7) Confidence 0.21 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2952802 Disease Relevance 2.57 Pain Relevance 0.07
Cytoplasmic antineutrophil cytoplasmic antibodies (c-ANCAs) directed against proteinase 3 (PR3) are more commonly found in WGs whereas perinuclear ANCAs (p-ANCA) targeting myeloperoxidase (MPO) are more frequently seen in MPA and CSS.
Regulation (targeting) of myeloperoxidase associated with syndrome, urological neuroanatomy and microscopic polyangiitis
8) Confidence 0.21 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2952802 Disease Relevance 2.57 Pain Relevance 0.07
Al-Shukaili, et al.43 reported that no change of MPO activity in the serum of patients with gastric cancer compared to healthy controls.
Neg (no) Regulation (change) of MPO associated with urological neuroanatomy and stomach cancer
9) Confidence 0.20 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768243 Disease Relevance 0.68 Pain Relevance 0
We observed no statistically significant treatment effect of 0.5 mg or 2 mg FP on MPO or total protein levels in sputum.
Neg (no) Regulation (effect) of MPO in sputum associated with urological neuroanatomy
10) Confidence 0.10 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2430237 Disease Relevance 0.27 Pain Relevance 0
The concentration of MPO and MMP-9 were also unaltered in BAL and BW following the wood smoke challenge, table 1.
Regulation (unaltered) of MPO associated with urological neuroanatomy
11) Confidence 0.08 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2936868 Disease Relevance 0.24 Pain Relevance 0

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