INT56223

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2011
Negated 3
Speculated 1
Reported most in Body
Documents 35
Total Number 39
Disease Relevance 43.00
Pain Relevance 8.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MPO) extracellular space (MPO) oxidoreductase activity (MPO)
aging (MPO) nucleus (MPO) lysosome (MPO)
Anatomy Link Frequency
plasma 5
neutrophil 3
blood 2
coronary sinus 1
platelet 1
MPO (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 381 100.00 Very High Very High Very High
Inflammatory marker 28 100.00 Very High Very High Very High
Pain 11 99.88 Very High Very High Very High
cINOD 34 99.82 Very High Very High Very High
ischemia 137 99.56 Very High Very High Very High
Angina 180 98.72 Very High Very High Very High
aspirin 9 98.36 Very High Very High Very High
Paracetamol 13 98.18 Very High Very High Very High
Bioavailability 17 97.32 Very High Very High Very High
Inflammatory mediators 9 96.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 608 100.00 Very High Very High Very High
INFLAMMATION 431 100.00 Very High Very High Very High
Heart Disease 17 100.00 Very High Very High Very High
Hemorrhage 11 100.00 Very High Very High Very High
Leukocytosis 4 99.90 Very High Very High Very High
Pain 11 99.88 Very High Very High Very High
Myocardial Infarction 300 99.84 Very High Very High Very High
Fabry Disease 42 99.84 Very High Very High Very High
Pressure And Volume Under Development 4 99.76 Very High Very High Very High
Cv Unclassified Under Development 100 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All the NSAIDs produced significant blood loss coincident with gastric ulceration but no increase in gastric or intestinal MPO activity.
Neg (no) Positive_regulation (increase) of MPO in blood associated with pressure volume 2 under development, cinod and urological neuroanatomy
1) Confidence 0.70 Published 2003 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 12831509 Disease Relevance 1.27 Pain Relevance 0.67
Moreover, heparin that is routinely used for anticoagulation during hemodialysis is known to activate MPO leading to increased ROS production [71].
Positive_regulation (activate) of MPO associated with urological neuroanatomy
2) Confidence 0.64 Published 2011 Journal Cardiology Research and Practice Section Body Doc Link PMC3022166 Disease Relevance 0.84 Pain Relevance 0.07
Furthermore, MPO, as marker of neutrophil activity, was significantly increased in both study groups.
Positive_regulation (increased) of MPO in neutrophil associated with urological neuroanatomy
3) Confidence 0.59 Published 2008 Journal Respir Res Section Body Doc Link PMC2253533 Disease Relevance 0.87 Pain Relevance 0
Nasal lavage fluid levels of MPO were increased 24 hours post TNF?
Positive_regulation (increased) of MPO in Nasal associated with urological neuroanatomy
4) Confidence 0.59 Published 2008 Journal Respir Res Section Body Doc Link PMC2253533 Disease Relevance 1.27 Pain Relevance 0.30
The finding is in agreement with our previous observation in allergic rhinitis, although that particular increase in MPO only reached borderline statistical significance [16].
Positive_regulation (increase) of MPO associated with rhinitis and urological neuroanatomy
5) Confidence 0.51 Published 2008 Journal Respir Res Section Body Doc Link PMC2253533 Disease Relevance 1.16 Pain Relevance 0.23
MPO is not likely to be specific for cardiac diseases, as activation of
Positive_regulation (activation) of MPO associated with heart disease and urological neuroanatomy
6) Confidence 0.50 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.78 Pain Relevance 0.17
Subsequent histopathology disclosed sheets of mononuclear cells in the orbital mass, and immunohistochemical stains demonstrated positive results for myeloperoxidase and CD43, which supported the diagnosis of granulocytic sarcoma (GS).
Positive_regulation (results) of myeloperoxidase in mononuclear cells associated with myeloid sarcoma
7) Confidence 0.48 Published 2008 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 18656695 Disease Relevance 1.04 Pain Relevance 0.08
department and that elevated plasma MPO levels may be a marker of unstable
Positive_regulation (elevated) of MPO in plasma associated with urological neuroanatomy
8) Confidence 0.47 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.12 Pain Relevance 0.15
30 days and 6 months with each quartile increase in MPO concentration in
Positive_regulation (increase) of MPO associated with urological neuroanatomy
9) Confidence 0.47 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.07 Pain Relevance 0.20
showed that blood and leukocyte MPO activity were higher in patients with CAD
Positive_regulation (higher) of MPO in leukocyte associated with coronary artery disease and urological neuroanatomy
10) Confidence 0.47 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276594 Disease Relevance 1.65 Pain Relevance 0
There was no statistically significant increase in gastric or intestinal mucosal MPO activity in the non-damaged mucosa with these drugs and this was confirmed by histological observations in non-lesioned areas of the mucosa.
Neg (no) Positive_regulation (increase) of MPO associated with urological neuroanatomy
11) Confidence 0.47 Published 2003 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 12831509 Disease Relevance 1.08 Pain Relevance 0.57
During genital inflammation, whether post-operative or postinfectious, leukocytosis and elevated levels of HYA and myeloperoxidase were found in the PF.
Positive_regulation (elevated) of myeloperoxidase associated with inflammation and leukocytosis
12) Confidence 0.47 Published 1994 Journal Inflammation Section Abstract Doc Link 8070899 Disease Relevance 0.53 Pain Relevance 0.26
During genital inflammation, whether postoperative or postinfectious, leukocytosis and elevated levels of HYA and myeloperoxidase were found in the PF.
Positive_regulation (elevated) of myeloperoxidase associated with inflammation and leukocytosis
13) Confidence 0.46 Published 1994 Journal Inflammation Section Abstract Doc Link 8206644 Disease Relevance 0.53 Pain Relevance 0.26
Since the therapeutic concentrations of acetaminophen in man range approximately from 50 to 150 microM, the results of this study indicate that stimulation of myeloperoxidase activity is achieved within the safe dosage of the drug.
Positive_regulation (stimulation) of myeloperoxidase associated with paracetamol
14) Confidence 0.46 Published 1993 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 8396889 Disease Relevance 0 Pain Relevance 0.75
pmol/L increase in MPO level.
Positive_regulation (increase) of MPO associated with urological neuroanatomy
15) Confidence 0.46 Published 2011 Journal Cardiology Research and Practice Section Body Doc Link PMC3022166 Disease Relevance 1.38 Pain Relevance 0
Myeloperoxidase (MPO) activity has been found to be increased during hemodialysis, especially with the use of bioincompatible dialysis membranes [70].
Positive_regulation (increased) of MPO associated with urological neuroanatomy
16) Confidence 0.43 Published 2011 Journal Cardiology Research and Practice Section Body Doc Link PMC3022166 Disease Relevance 1.15 Pain Relevance 0.06
Myeloperoxidase (MPO) activity has been found to be increased during hemodialysis, especially with the use of bioincompatible dialysis membranes [70].
Positive_regulation (increased) of Myeloperoxidase associated with urological neuroanatomy
17) Confidence 0.43 Published 2011 Journal Cardiology Research and Practice Section Body Doc Link PMC3022166 Disease Relevance 1.16 Pain Relevance 0.06
We have no specific explanation for the present numerically higher levels of MPO observed in healthy subjects (c.f. patients with allergic rhinitis) following TNF?
Positive_regulation (levels) of MPO associated with rhinitis and urological neuroanatomy
18) Confidence 0.39 Published 2008 Journal Respir Res Section Body Doc Link PMC2253533 Disease Relevance 0.83 Pain Relevance 0.09
Individuals with elevated MPO levels on the examination day had greater impairment of FMD in association with PM2.5 than did individuals with low MPO levels on that day.
Positive_regulation (elevated) of MPO associated with urological neuroanatomy
19) Confidence 0.38 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2599761 Disease Relevance 0.87 Pain Relevance 0
Some authors found that MPO serum levels were equally distributed among patients with low and high Troponin T (TnT) serum levels, which indicates that elevated MPO levels are not temporary related to myocardial injury.47 Moreover, MPO identifies patients at risk for cardiovascular events who have low baseline TnT levels, even before complete microvascular obstruction.
Positive_regulation (elevated) of MPO associated with injury and urological neuroanatomy
20) Confidence 0.37 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.63 Pain Relevance 0.28

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