INT56224

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Context Info
Confidence 0.58
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 40
Total Number 40
Disease Relevance 23.34
Pain Relevance 25.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
NK cell 14
lymph node 8
T cell 8
B-cell 6
macrophages 4
Ifng (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 139 100.00 Very High Very High Very High
cytokine 64 100.00 Very High Very High Very High
cINOD 16 99.98 Very High Very High Very High
nud 4 99.84 Very High Very High Very High
fluoxetine 6 99.70 Very High Very High Very High
Neuritis 103 99.68 Very High Very High Very High
Morphine 49 99.68 Very High Very High Very High
Buprenorphine 6 99.64 Very High Very High Very High
chemokine 6 99.64 Very High Very High Very High
antidepressant 17 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 154 100.00 Very High Very High Very High
Anxiety Disorder 6 100.00 Very High Very High Very High
Dyspepsia 4 99.84 Very High Very High Very High
Experimental Autoimmune Neuritis 102 99.68 Very High Very High Very High
Recurrence 10 99.68 Very High Very High Very High
Immunization 21 99.60 Very High Very High Very High
Schizophrenia 220 98.98 Very High Very High Very High
Nociception 9 98.12 Very High Very High Very High
Stress 26 96.64 Very High Very High Very High
Disease 63 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In rats that received chronic morphine via the minipump, the morphine injection also suppressed mitogen-stimulated splenocyte proliferation and gamma-IFN production but did not suppress NK cell activity.
Negative_regulation (suppressed) of Gene_expression (production) of gamma-IFN in NK cell associated with morphine
1) Confidence 0.58 Published 1998 Journal Drug Alcohol Depend Section Abstract Doc Link 10933338 Disease Relevance 0 Pain Relevance 0.90
Indeed, formalin injection per se decreased IFN-gamma production; estradiol had no effect on sham-injected animals but strongly reduce the decrease of IFN-gamma production in formalin-injected animals.
Negative_regulation (reduce) of Gene_expression (production) of IFN-gamma
2) Confidence 0.58 Published 2004 Journal Pain Section Abstract Doc Link 15327822 Disease Relevance 0.27 Pain Relevance 0.55
Indeed, formalin injection per se decreased IFN-gamma production; estradiol had no effect on sham-injected animals but strongly reduce the decrease of IFN-gamma production in formalin-injected animals.
Negative_regulation (decreased) of Gene_expression (production) of IFN-gamma
3) Confidence 0.58 Published 2004 Journal Pain Section Abstract Doc Link 15327822 Disease Relevance 0.28 Pain Relevance 0.56
It attenuated the expressions of ethanol-induced pro-inflammatory cytokines, including interleukin (IL)-1beta and interferon-gamma, a weak activation of IL-10, the inhibition of the alcohol-induced overexpression of intercellular adhesion molecule-1, and the considerable induction of heat shock protein-72 expression in gastric mucosal homogenates.
Negative_regulation (attenuated) of Gene_expression (expressions) of interferon-gamma
4) Confidence 0.57 Published 2008 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 18444990 Disease Relevance 0.07 Pain Relevance 0
The results demonstrate that buprenorphine dose-dependently suppresses splenic natural killer cell activity, lymphocyte proliferation and IFN-gamma production in rats in a naltrexone reversible manner, demonstrating pharmacological specificity of buprenorphine-induced immune alterations.
Negative_regulation (suppresses) of Gene_expression (production) of IFN-gamma in lymphocyte associated with buprenorphine
5) Confidence 0.57 Published 2004 Journal Int. Immunopharmacol. Section Abstract Doc Link 15037219 Disease Relevance 0.17 Pain Relevance 1.37
Clonidine dose dependently prevented withdrawal-induced suppression of Con-A and TSST-1-stimulated splenocyte proliferation, Con-A-stimulated splenocyte IFN-gamma production, and splenic NK cell activity.
Negative_regulation (suppression) of Gene_expression (production) of IFN-gamma in NK cell
6) Confidence 0.53 Published 1999 Journal Psychopharmacology (Berl.) Section Body Doc Link 10541733 Disease Relevance 0 Pain Relevance 0
In the drinking groups, the acute morphine injection significantly suppressed splenic natural killer (NK) cell activity, mitogen-stimulated splenic T- and B-cell proliferation and gamma-interferon (gamma-IFN) production.
Negative_regulation (suppressed) of Gene_expression (production) of gamma-interferon in B-cell associated with morphine
7) Confidence 0.43 Published 1997 Journal Drug Alcohol Depend Section Abstract Doc Link 9250473 Disease Relevance 0.06 Pain Relevance 1.05
A single, acute injection of morphine did not suppress NK cell activity in rats that drank the two highest concentrations of morphine, whereas it did suppress the mitogen-stimulated splenic T- and B-cell proliferation and gamma-IFN production.
Negative_regulation (suppress) of Gene_expression (production) of gamma-IFN in B-cell associated with morphine
8) Confidence 0.43 Published 1997 Journal Drug Alcohol Depend Section Abstract Doc Link 9250473 Disease Relevance 0.08 Pain Relevance 1.16
Chronically stressed rats also exhibited anxiety-like behaviors, enhanced fecal pellet excretion, and small but significant increases in the mast cell numbers and the expression of IL-1beta and IFN-gamma.
Negative_regulation (exhibited) of Gene_expression (expression) of IFN-gamma in mast cell associated with anxiety disorder
9) Confidence 0.43 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15746211 Disease Relevance 1.69 Pain Relevance 0.26
Indeed, formalin injection per se decreased IFN-gamma production; estradiol had no effect on sham-injected animals but strongly reduce the decrease of IFN-gamma production in formalin-injected animals.
Negative_regulation (decrease) of Gene_expression (production) of IFN-gamma
10) Confidence 0.43 Published 2004 Journal Pain Section Abstract Doc Link 15327822 Disease Relevance 0.26 Pain Relevance 0.55
This aversive conditioned stimulus induces a reduction in splenic natural killer cell activity, splenocyte proliferation in response to mitogens, and diminished levels of interferon-gamma (IFN-gamma) production by splenocytes.
Negative_regulation (levels) of Gene_expression (production) of interferon-gamma in natural killer cell
11) Confidence 0.42 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9394782 Disease Relevance 0 Pain Relevance 0.54
This aversive conditioned stimulus induces a reduction in splenic natural killer cell activity, splenocyte proliferation in response to mitogens, and diminished levels of interferon-gamma (IFN-gamma) production by splenocytes.
Negative_regulation (diminished) of Gene_expression (production) of interferon-gamma in natural killer cell
12) Confidence 0.42 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9394782 Disease Relevance 0 Pain Relevance 0.54
Clonidine dose dependently prevented withdrawal-induced suppression of Con-A and TSST-1-stimulated splenocyte proliferation, Con-A-stimulated splenocyte IFN-gamma production, and splenic NK cell activity.
Negative_regulation (prevented) of Gene_expression (production) of IFN-gamma in NK cell
13) Confidence 0.39 Published 1999 Journal Psychopharmacology (Berl.) Section Body Doc Link 10541733 Disease Relevance 0 Pain Relevance 0
Results showed that naltrexone attenuated the surgery-induced decrease in natural killer cell cytotoxicity, B-cell proliferation, T-cell proliferation, and production of the cytokine IFN-gamma.
Negative_regulation (decrease) of Gene_expression (production) of cytokine IFN-gamma in T-cell associated with cytokine
14) Confidence 0.37 Published 2000 Journal J. Surg. Res. Section Abstract Doc Link 11104658 Disease Relevance 0 Pain Relevance 0.31
However, maprotiline at 10(-4)-10(-6) M suppressed class I expression in the presence of 0.5 U/ml and 1.0 U/ml of IFN-gamma.
Negative_regulation (suppressed) of Gene_expression (expression) of IFN-gamma
15) Confidence 0.37 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8071062 Disease Relevance 0.51 Pain Relevance 0.91
Feeding with Lyprinol was associated with significantly decreased expression levels of TNF-alpha and IFN-gamma when compared to Naproxen (positive control) and, even more when compared with sham and extra-virgin olive oil (negative control).
Negative_regulation (decreased) of Gene_expression (levels) of IFN-gamma
16) Confidence 0.35 Published 2008 Journal Eur Ann Allergy Clin Immunol Section Abstract Doc Link 19227651 Disease Relevance 0.69 Pain Relevance 0.47
In contrast, resistance to EAN in SD rats is associated with reduced BPM and P2 peptide-reactive IFN-gamma production, TNF-alpha mRNA expression, and suppressed B cell responses to PNS myelin antigens as well as up-regulation of TGF-beta and IL-10 mRNA expression.
Negative_regulation (reduced) of Gene_expression (production) of IFN-gamma in B cell associated with peripheral nervous system and neuritis
17) Confidence 0.29 Published 1998 Journal J. Neurosci. Res. Section Abstract Doc Link 9819142 Disease Relevance 1.13 Pain Relevance 1.30
Feeding with Lyprinol was associated with significantly decreased expression levels of TNF-alpha and IFN-gamma when compared to Naproxen (positive control) and, even more when compared with sham and extra-virgin olive oil (negative control).
Negative_regulation (decreased) of Gene_expression (expression) of IFN-gamma
18) Confidence 0.26 Published 2008 Journal Eur Ann Allergy Clin Immunol Section Abstract Doc Link 19227651 Disease Relevance 0.69 Pain Relevance 0.47
Our data suggest that oral administration of IFN-alpha/beta reduces the severity of EAN, possibly by a reduction in IFN-gamma production.
Negative_regulation (reduction) of Gene_expression (production) of IFN-gamma associated with neuritis
19) Confidence 0.24 Published 1996 Journal Autoimmunity Section Abstract Doc Link 9020408 Disease Relevance 0.91 Pain Relevance 0.57
In situ IFN-gamma production and inflammation were reduced when evaluated by immunocytochemistry at day 13 after immunization.
Negative_regulation (reduced) of Gene_expression (production) of IFN-gamma associated with inflammation and immunization
20) Confidence 0.24 Published 1996 Journal Autoimmunity Section Abstract Doc Link 9020408 Disease Relevance 0.99 Pain Relevance 0.63

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