INT56229

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.25
First Reported 1994
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.06
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
peritoneal macrophages 2
trigeminal ganglia 1
brain stem 1
RT1-EC2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 16 99.60 Very High Very High Very High
Neuritis 23 98.56 Very High Very High Very High
cytokine 8 90.76 High High
Endep 6 87.96 High High
Nortriptyline 4 87.36 High High
monoamine 4 75.00 Quite High
Inflammation 13 62.48 Quite High
Peripheral nervous system 1 48.80 Quite Low
Demyelination 1 47.20 Quite Low
fifth nerve 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 23 98.56 Very High Very High Very High
Demyelinating Disease 4 98.48 Very High Very High Very High
Autoimmune Disease 4 97.92 Very High Very High Very High
Sprains And Strains 47 87.20 High High
Necrosis 2 64.92 Quite High
Cancer 1 64.56 Quite High
INFLAMMATION 16 62.48 Quite High
Syndrome 1 54.68 Quite High
Herpes Simplex Virus 4 50.00 Quite Low
Infection 29 49.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The modulatory effect of antidepressant drugs on IFN-gamma induced MHC class I and II expression may contribute to their influence on demyelinating autoimmune diseases, and may have implications for their clinical use.
Positive_regulation (induced) of Gene_expression (expression) of MHC class I and II associated with antidepressant, autoimmune disease and demyelinating disease
1) Confidence 0.25 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8071062 Disease Relevance 0.59 Pain Relevance 0.64
This study examined the modulation of IFN-gamma induced MHC class I and II expression on normal Lewis rats and rats with EAN peritoneal macrophages cultured in the absence or presence of 10(-4)-10(-8) M of the 5-HT reuptake inhibiting antidepressants zimeldine, and its metabolites norzimeldine and cpp200 oxalate as well as the antidepressants clomipramine and imipramine, in addition amitriptyline, nortriptyline and maprotiline in EAN rats.
Spec (examined) Positive_regulation (induced) of Gene_expression (expression) of MHC class I and II in peritoneal macrophages associated with nortriptyline, antidepressant, endep and neuritis
2) Confidence 0.25 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8071062 Disease Relevance 0.33 Pain Relevance 0.62
The modulatory effect of antidepressant drugs on IFN-gamma induced MHC class I and II expression may contribute to their influence on demyelinating autoimmune diseases, and may have implications for their clinical use.
Positive_regulation (induced) of Gene_expression (expression) of MHC class I and II associated with antidepressant, autoimmune disease and demyelinating disease
3) Confidence 0.24 Published 1997 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 10975734 Disease Relevance 0.89 Pain Relevance 0.80
In the trigeminal ganglia of DA rats up-regulation of MHC I was seen from 12 hpi, and MHC II from 3 dpi, whereas in the brain stem level of MHC I expression was increased from 2 dpi and level of MHC II expression from 3 dpi.
Positive_regulation (increased) of in trigeminal ganglia Gene_expression (expression) of MHC I in brain stem
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.23 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox