INT5623

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2010
Negated 9
Speculated 4
Reported most in Abstract
Documents 174
Total Number 179
Disease Relevance 69.96
Pain Relevance 52.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
plasma 58
heart 9
blood 6
urine 3
neurons 3
Nppa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 220 100.00 Very High Very High Very High
Dopamine 25 100.00 Very High Very High Very High
Enkephalin 23 100.00 Very High Very High Very High
Calcitonin gene-related peptide 18 100.00 Very High Very High Very High
opiate 15 100.00 Very High Very High Very High
depression 14 100.00 Very High Very High Very High
Neuropeptide 7 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
Morphine 112 99.98 Very High Very High Very High
agonist 105 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 405 100.00 Very High Very High Very High
Acute Necrotizing Pancreatitis 156 100.00 Very High Very High Very High
Coronary Artery Disease 34 100.00 Very High Very High Very High
Ganglion Cysts 30 100.00 Very High Very High Very High
Shock 16 100.00 Very High Very High Very High
Post-partum Depression 9 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 15 99.90 Very High Very High Very High
Heart Rate Under Development 23 99.84 Very High Very High Very High
Stress 20 99.84 Very High Very High Very High
Hypertension 95 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared with the control rats, we found for the first time a significant decrease of ANF in plasma and a marked increase of ANF in atria in morphine tolerant rats.
Positive_regulation (increase) of ANF in plasma associated with morphine
1) Confidence 0.70 Published 1989 Journal Sheng Li Xue Bao Section Abstract Doc Link 2533995 Disease Relevance 0.07 Pain Relevance 0.38
A short, transient increase in blood pressure, occurred 2-5 min after morphine administration, but it is unlikely that this increase accounted for the increase in plasma ANF.
Positive_regulation (increase) of ANF in blood associated with pressure and volume under development and morphine
2) Confidence 0.70 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8223938 Disease Relevance 0.37 Pain Relevance 0.67
Morphine injection also significantly increased the plasma ANF level to a maximum of 364 +/- 46 pg/ml compared to control animals (33 +/- 7 pg/ml) in which 20 microliters of saline was injected i.c.v.
Positive_regulation (increased) of ANF in plasma associated with morphine
3) Confidence 0.70 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8223938 Disease Relevance 0.38 Pain Relevance 0.53
Clonidine injection in a dose of 50 micrograms caused a marked increase of plasma IR-ANF from 34.0 +/- 7.0 pg/ml (mean +/- S.E.M.) to 457.1 +/- 66.3 pg/ml.
Positive_regulation (increase) of ANF in plasma associated with clonidine
4) Confidence 0.70 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3035429 Disease Relevance 0.15 Pain Relevance 0.55
Since ANF is a potent natriuretic and diuretic hormone, the morphine-induced increase of plasma IR-ANF may provide a rational basis for explaining the diuretic effect of morphine in conscious non-hydrated rats.
Positive_regulation (increase) of ANF in plasma associated with natriuresis and morphine
5) Confidence 0.70 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2949987 Disease Relevance 0.17 Pain Relevance 0.76
Central infusion of morphine (100 ng/min) also elevated plasma ANP levels and naloxone (5 micrograms/min) blunted this effect.
Positive_regulation (elevated) of ANP in plasma associated with narcan and morphine
6) Confidence 0.70 Published 1989 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 2525782 Disease Relevance 0.16 Pain Relevance 1.04
Clonidine, an alpha 2-adrenergic agonist, induced a marked, dose-related increase of plasma IR-ANF in normally-hydrated rats.
Positive_regulation (increase) of ANF in plasma associated with agonist and clonidine
7) Confidence 0.70 Published 1987 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3030313 Disease Relevance 0.07 Pain Relevance 0.58
In conscious rats with chronic indwelling catheters, volume loading with isotonic saline or glucose increased the amount of circulating immunoreactive ANP's by a factor of 4 to 5, as determined by radioimmunoassay.
Positive_regulation (increased) of ANP
8) Confidence 0.70 Published 1986 Journal Science Section Abstract Doc Link 2938258 Disease Relevance 0.16 Pain Relevance 0.14
The quaternary antagonist N-methylnaltrexone (1 mg/kg) failed to block the fentanyl-induced increase of ANF, suggesting that opiates bring about their action on ANF via a central mechanism.
Positive_regulation (increase) of ANF associated with antagonist and opiate
9) Confidence 0.69 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2961585 Disease Relevance 0.14 Pain Relevance 0.54
We found that mu-opioid receptor agonists, given subcutaneously, increased plasma IR-ANF, while kappa-receptor agonists did not alter the plasma levels of IR-ANF.
Positive_regulation (increased) of ANF in plasma associated with agonist and opioid receptor
10) Confidence 0.69 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2961585 Disease Relevance 0.17 Pain Relevance 0.46
Ether anesthesia and morphine markedly increased IR-ANF in rat plasma.
Positive_regulation (increased) of ANF in plasma associated with anesthesia and morphine
11) Confidence 0.69 Published 1986 Journal Fed. Proc. Section Abstract Doc Link 2872084 Disease Relevance 0.26 Pain Relevance 0.20
Paroxysmal tachycardia and rapid atrial pacing significantly increased IR-ANF in human plasma.
Positive_regulation (increased) of ANF in plasma associated with heart rate under development
12) Confidence 0.69 Published 1986 Journal Fed. Proc. Section Abstract Doc Link 2872084 Disease Relevance 0.26 Pain Relevance 0.18
These renal responses were associated with increased plasma ANF (59 +/- 7 vs. 810 +/- 28 pg/ml, P < .001, n = 12), measured 10 min after ST-91 (250 micrograms/rat), which remained elevated for at least 1 h (P < .01, n = 6).
Positive_regulation (increased) of ANF in plasma
13) Confidence 0.69 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9152372 Disease Relevance 0.30 Pain Relevance 0.44
Diuretic and natriuretic effects of ANF were increased in rats treated with SCH 42495.
Positive_regulation (increased) of ANF associated with natriuresis
14) Confidence 0.69 Published 1993 Journal Am. J. Hypertens. Section Abstract Doc Link 8512660 Disease Relevance 0.51 Pain Relevance 0.09
Morphine induced a transient, dose-dependent reduction in blood pressure (from 114+/-1 to 71+/-6 mm Hg at 10.0 mg/kg body weight) and a dose-dependent elevation of plasma ANF.
Positive_regulation (elevation) of ANF in body associated with body weight and morphine
15) Confidence 0.69 Published 1997 Journal Kidney Blood Press. Res. Section Abstract Doc Link 9192906 Disease Relevance 0.32 Pain Relevance 0.57
A significant increase of ANP was found after iv injection of clonidine in the control group and in obesity (p < 0.001 and p < 0.01, respectively).
Positive_regulation (increase) of ANP associated with obesity and clonidine
16) Confidence 0.69 Published 1995 Journal Eur. J. Endocrinol. Section Abstract Doc Link 7858731 Disease Relevance 1.68 Pain Relevance 0.24
Additionally, plasma and urine LANP and ANF peptide levels were increased following lidocaine infusion, while plasma and urine concentrations of vessel dilator were not changed.
Positive_regulation (increased) of ANF in urine associated with lidocaine
17) Confidence 0.69 Published 1997 Journal Life Sci. Section Abstract Doc Link 9042375 Disease Relevance 0.40 Pain Relevance 0.61
Reports from other laboratories have shown that atrial natriuretic peptide (ANP) stores in sympathetic ganglia are increased during dietary NaCl supplementation in normotensive rats.
Positive_regulation (increased) of atrial natriuretic peptide in sympathetic associated with natriuresis
18) Confidence 0.68 Published 1992 Journal Am. J. Hypertens. Section Abstract Doc Link 1457081 Disease Relevance 0.63 Pain Relevance 0
Dietary NaCl supplementation produced significant increases in blood pressure in SHR-S, but not in WKY rats; the high NaCl diet was associated with significant increases in the ANP content of superior cervical and celiac ganglia in WKY rats, but not in SHR-S.
Neg (not) Positive_regulation (increases) of ANP in superior associated with pressure and volume under development
19) Confidence 0.68 Published 1992 Journal Am. J. Hypertens. Section Abstract Doc Link 1457081 Disease Relevance 0.72 Pain Relevance 0.09
The current study tested the hypothesis that ganglion ANP levels increase in WKY but not in SHR-S during dietary NaCl supplementation.
Neg (not) Positive_regulation (increase) of ANP in ganglion associated with ganglion cysts
20) Confidence 0.68 Published 1992 Journal Am. J. Hypertens. Section Abstract Doc Link 1457081 Disease Relevance 0.88 Pain Relevance 0.09

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