INT56230

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Context Info
Confidence 0.13
First Reported 1994
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.70
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 1
brain stem 1
RT1-EC2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 7 99.84 Very High Very High Very High
antidepressant 7 99.46 Very High Very High Very High
Serotonin 3 99.16 Very High Very High Very High
Hippocampus 2 96.88 Very High Very High Very High
adenocard 1 90.40 High High
fluoxetine 2 83.92 Quite High
monoamine 1 75.00 Quite High
Endep 3 73.84 Quite High
Nortriptyline 2 72.48 Quite High
Inflammation 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 7 99.84 Very High Very High Very High
Sprains And Strains 47 85.52 High High
Viral Meningitis 32 53.20 Quite High
Herpes Simplex Virus 4 50.00 Quite Low
Infection 29 46.12 Quite Low
Cold Sores 61 45.64 Quite Low
INFLAMMATION 14 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 3 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 5-HT reuptake inhibiting antidepressants also exerted a modulatory effect on MHC class I and II in EAN rat macrophages even in the absence of IFN-gamma.
Regulation (effect) of MHC class I and II in macrophages associated with antidepressant and neuritis
1) Confidence 0.13 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8071062 Disease Relevance 0.41 Pain Relevance 0.68
We hypothesized that the serotonin N-acetyltransferase (AA-NAT; EC 2.3.1.87) gene is one such target.
Regulation (target) of EC 2.3.1.87 associated with serotonin
2) Confidence 0.05 Published 1999 Journal Biol. Psychiatry Section Abstract Doc Link 9951564 Disease Relevance 0 Pain Relevance 0.47
No up-regulation of MHC I or II was visible in the trigeminal ganglia or the brain stem of the PVG rats (Table 1).


Regulation (regulation) of MHC I in brain stem
3) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929186 Disease Relevance 0.29 Pain Relevance 0

General Comments

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