INT56233

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Context Info
Confidence 0.18
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 1.25
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (RT1-Cl) cellular_component (RT1-Cl) biological_process (RT1-Cl)
RT1-Cl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 21 99.86 Very High Very High Very High
antidepressant 18 99.08 Very High Very High Very High
Nortriptyline 6 98.16 Very High Very High Very High
Endep 9 97.56 Very High Very High Very High
monoamine 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 21 99.86 Very High Very High Very High
Demyelinating Disease 3 5.00 Very Low Very Low Very Low
Autoimmune Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In normal rats, MHC class I expression was suppressed by the antidepressants zimeldine, norzimeldine and cpp200 oxalate at concentrations up to 10(-5) M.
Gene_expression (expression) of MHC class I associated with antidepressant
1) Confidence 0.18 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8071062 Disease Relevance 0.40 Pain Relevance 0.77
Clomipramine at 10(-8) M and imipramine at 10(-6)-10(-7) M enhanced MHC class I expression, while the MHC class II expression was not significantly influenced by concentrations < or = 10(-5) M of these two drugs.
Gene_expression (expression) of MHC class I
2) Confidence 0.15 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8071062 Disease Relevance 0.40 Pain Relevance 0.77
In EAN rats, MHC class I expression was enhanced by zimeldine, cpp200, imipramine, and nortriptyline at 10(-5)-10(-8) M, amitriptyline at 10(-5)-10(-7) M as well as by norzimeldine and clomipramine at 10(-6) M-10(-8) M.
Gene_expression (expression) of MHC class I associated with nortriptyline, endep and neuritis
3) Confidence 0.14 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 8071062 Disease Relevance 0.45 Pain Relevance 0.82

General Comments

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