INT5624

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Context Info
Confidence 0.69
First Reported 1991
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 19
Total Number 21
Disease Relevance 8.52
Pain Relevance 4.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
auricles 4
neurons 3
cardiac myocyte 2
EPI 2
myocytes 1
Nppa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 20 99.62 Very High Very High Very High
Hyperalgesia 42 98.24 Very High Very High Very High
dexamethasone 16 98.08 Very High Very High Very High
Neurotransmitter 4 93.92 High High
Clonidine 12 92.92 High High
fibrosis 16 92.16 High High
cINOD 1 91.48 High High
Angina 3 89.96 High High
agonist 22 89.64 High High
anesthesia 14 87.16 High High
Disease Link Frequency Relevance Heat
Natriuresis 31 100.00 Very High Very High Very High
Hypertension 9 99.76 Very High Very High Very High
Myocardial Infarction 83 99.60 Very High Very High Very High
Hyperalgesia 42 98.24 Very High Very High Very High
Heart Rate Under Development 21 96.12 Very High Very High Very High
Apoptosis 40 95.12 Very High Very High Very High
Diabetes Mellitus 55 94.28 High High
Fibrosis 14 92.16 High High
INFLAMMATION 34 91.24 High High
Cv General 3 Under Development 3 89.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For onset variation, CI was started either on PND8, PND10, or PND14 (PND21 was tested earlier [18]).
Transcription (started) of PND14
1) Confidence 0.69 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2518152 Disease Relevance 0.10 Pain Relevance 0.10
For onset variation, CI was started either on PND8, PND10, or PND14 (PND21 was tested earlier [18]).
Transcription (started) of PND10
2) Confidence 0.69 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2518152 Disease Relevance 0.10 Pain Relevance 0.10
For onset variation, CI was started either on PND8, PND10, or PND14 (PND21 was tested earlier [18]).
Transcription (started) of PND8
3) Confidence 0.69 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2518152 Disease Relevance 0.10 Pain Relevance 0.10
The expression of ANP and natriuretic peptide receptor-A (NPR-A) mRNA was determined in the kidney, as was that of endothelial NO synthase (NOS) proteins.
Transcription (expression) of ANP in kidney associated with natriuresis
4) Confidence 0.68 Published 2004 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 15053815 Disease Relevance 0.28 Pain Relevance 0.09
We investigated the influences of two potent stimuli, water deprivation (5 days) and morphine administration (100 mg/kg), on the level of atrial natriuretic peptide (ANP) mRNA in the rat auricles.
Transcription (level) of ANP in auricles associated with natriuresis and morphine
5) Confidence 0.53 Published 1991 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1839321 Disease Relevance 0.17 Pain Relevance 0.32
We investigated the influences of two potent stimuli, water deprivation (5 days) and morphine administration (100 mg/kg), on the level of atrial natriuretic peptide (ANP) mRNA in the rat auricles.
Transcription (level) of atrial natriuretic peptide in auricles associated with natriuresis and morphine
6) Confidence 0.53 Published 1991 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1839321 Disease Relevance 0.17 Pain Relevance 0.31
The ANP mRNA level was measured by Northern blot hybridization analysis.
Transcription (level) of ANP
7) Confidence 0.53 Published 1991 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1839321 Disease Relevance 0.17 Pain Relevance 0.32
The plasma concentration of ANP decreased in water deprived rats, and the ANP mRNA levels in both auricles of these rats were lower than those of the control, particularly in the left auricle.
Transcription (levels) of ANP in auricles
8) Confidence 0.53 Published 1991 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1839321 Disease Relevance 0.17 Pain Relevance 0.34
In the failing right ventricle of the PH group, the expression of atrial natriuretic peptide (ANP) mRNA, which is a molecular marker for the failing heart, was markedly increased.
Transcription (expression) of ANP in heart associated with natriuresis and hypertension
9) Confidence 0.52 Published 2000 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 11078411 Disease Relevance 1.15 Pain Relevance 0.19
Norepinephrine stimulates immunoreactive (ir) atrial natriuretic peptide (ANP) secretion and pro-ANP mRNA expression from rat hypothalamic neurons in culture: effects of alpha 2-adrenoceptors.
Transcription (expression) of ANP in neurons associated with natriuresis
10) Confidence 0.51 Published 1992 Journal Endocrinology Section Title Doc Link 1312457 Disease Relevance 0.10 Pain Relevance 0.11
These changes were accompanied by corresponding increments in the abundance of pro-ANP mRNA in the cultures as examined by a colorimetric Northern blot analysis.
Transcription (abundance) of ANP
11) Confidence 0.51 Published 1992 Journal Endocrinology Section Abstract Doc Link 1312457 Disease Relevance 0.07 Pain Relevance 0.54
We report here that norepinephrine or epinephrine (NE/EPI) facilitates irANP secretion and pro-ANP mRNA expression in long term cultures of rat hypothalamic neurons through their effects on alpha 2-adrenoceptors.
Transcription (expression) of ANP in EPI
12) Confidence 0.51 Published 1992 Journal Endocrinology Section Abstract Doc Link 1312457 Disease Relevance 0.07 Pain Relevance 0.10
We report here that norepinephrine or epinephrine (NE/EPI) facilitates irANP secretion and pro-ANP mRNA expression in long term cultures of rat hypothalamic neurons through their effects on alpha 2-adrenoceptors.
Transcription (expression) of irANP in EPI
13) Confidence 0.51 Published 1992 Journal Endocrinology Section Abstract Doc Link 1312457 Disease Relevance 0.07 Pain Relevance 0.10
Effects of water deprivation and morphine administration on atrial natriuretic peptide mRNA levels in rat auricles.
Transcription (levels) of atrial natriuretic peptide in auricles associated with natriuresis and morphine
14) Confidence 0.47 Published 1991 Journal Jpn. J. Pharmacol. Section Title Doc Link 1839321 Disease Relevance 0.19 Pain Relevance 0.35
Aortic banding increased left ventricular expression of NPR-A and NPR-C mRNA by 110% (P < 0.001) and 520% (P < 0.01), respectively, after 8 wk; as expected, it also increased the expression of ANP and BNP mRNAs.
Transcription (expression) of ANP in BNP
15) Confidence 0.42 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16272201 Disease Relevance 0.78 Pain Relevance 0.24
MI tended to increase ANP mRNA expression in Wistar and GK rats (Figure 2D).


Transcription (expression) of ANP associated with myocardial infarction
16) Confidence 0.34 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 2.08 Pain Relevance 0.05
Expression of atrial natriuretic peptide (ANP) mRNA and protein synthesis was examined in cardiac myocyte by stimulation of IL-18.
Spec (examined) Transcription (Expression) of ANP in cardiac myocyte associated with natriuresis
17) Confidence 0.16 Published 2000 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 11758978 Disease Relevance 0.85 Pain Relevance 0.17
Expression of atrial natriuretic peptide (ANP) mRNA and protein synthesis was examined in cardiac myocyte by stimulation of IL-18.
Spec (examined) Transcription (Expression) of atrial natriuretic peptide in cardiac myocyte associated with natriuresis
18) Confidence 0.16 Published 2000 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 11758978 Disease Relevance 0.85 Pain Relevance 0.17
Increased expression of ANP mRNA was demonstrated in IL-18 treated myocytes.
Transcription (expression) of ANP in myocytes
19) Confidence 0.12 Published 2000 Journal Res. Commun. Mol. Pathol. Pharmacol. Section Abstract Doc Link 11758978 Disease Relevance 0.78 Pain Relevance 0.15
We conclude from the above observations that glucocorticoids modulate irANP secretion and pro-ANP mRNA expression in hypothalamic neurons by altering the responsiveness of the cells from alpha 2-AR to that of beta-AR.
Transcription (expression) of irANP in neurons
20) Confidence 0.12 Published 1992 Journal Endocrinology Section Abstract Doc Link 1324165 Disease Relevance 0 Pain Relevance 0.46

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