INT56272

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Context Info
Confidence 0.52
First Reported 1994
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.17
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp2e1, Cyp1a2) endoplasmic reticulum (Cyp2e1, Cyp1a2) enzyme binding (Cyp2e1, Cyp1a2)
mitochondrion (Cyp2e1)
Cyp2e1 (Mus musculus)
Cyp1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 11 97.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatotoxicity 1 95.76 Very High Very High Very High
Toxicity 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of acetaminophen (APAP) dose on the cytochrome P450s responsible for its bioactivation was examined in control mice and mice treated with acetone to induce CYP2E1, or beta-napthaflavone to induce CYP1A2.
CYP2E1 Positive_regulation (induce) of CYP1A2 associated with paracetamol
1) Confidence 0.52 Published 1994 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 8074700 Disease Relevance 0.17 Pain Relevance 0.77

General Comments

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